Short-chain acyl post-translational modifications in cancers: Mechanisms, roles, and therapeutic implications [0.03%]
癌症中的短链酰基蛋白质翻译后修饰：机制、功能及治疗意义
Ting Wu,Yingqi Zhao,Xin Zhang et al.
Ting Wu et al.
Post-translational modifications (PTMs) play a pivotal role in epigenetic regulation and are key pathways for modulating protein functionality. PTMs involve the covalent attachment of distinct chemical groups, such as succinyl, crotonyl, an...
Stereotactic body radiotherapy plus cadonilimab (PD-1/CTLA-4 bispecific antibody) as third-line or beyond therapy for refractory solid tumors: A phase 1b study [0.03%]
立体定向放疗联合卡度尼利单抗（PD-1/CTLA-4双特异性抗体）治疗难治性实体瘤 III 期或更晚线治疗：Ib 期临床研究
Yao Xiao,Yuxia Wang,Jun Li et al.
Yao Xiao et al.
Background: Cadonilimab is a humanized immunoglobulin G1 bispecific antibody targeting programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4). This study aimed to evaluate the safe...
Lifileucel tumor-infiltrating lymphocyte cell therapy in patients with unresectable or metastatic mucosal melanoma after disease progression on immune checkpoint inhibitors [0.03%]
免疫检查点抑制剂治疗后进展的不可切除或转移性黏膜黑色素瘤患者的TIL细胞疗法
Harriet Kluger,Götz Ulrich Grigoleit,Sajeve Thomas et al.
Harriet Kluger et al.
Targeting SPHK1 in macrophages remodels the tumor microenvironment and enhances anti-PD-1 immunotherapy efficacy in colorectal cancer liver metastasis [0.03%]
靶向结直肠癌肝转移肿瘤相关巨噬细胞中的SPHK1改善抗PD-1免疫治疗疗效
Yizhi Zhan,Jinsong Xu,Zhanqiao Zhang et al.
Yizhi Zhan et al.
Background: Colorectal cancer liver metastasis (CRLM) is characterized by an immunosuppressive microenvironment and a blunted response to immunotherapy. Notably, tumor-associated macrophages (TAMs) play a critical role in...
Comparative single-cell analysis of esophageal cancer subtypes reveals tumor microenvironment distinctions explaining varied immunotherapy responses [0.03%]
食管癌亚型的单细胞分析比较揭示了影响不同免疫治疗反应的肿瘤微环境差异
Seungbyn Baek,Junha Cha,Min Hee Hong et al.
Seungbyn Baek et al.
A serum exosomal microRNA-based artificial intelligence diagnostic model for highly accurate detection of hepatocellular carcinoma [0.03%]
一种基于血清外泌体微小RNAs的肝细胞癌人工智能诊断模型
Jin-Seong Hwang,Sugi Lee,Gyeonghwa Kim et al.
Jin-Seong Hwang et al.
NAT10 regulates tumor progression and immune microenvironment in pancreatic ductal adenocarcinoma via the N4-acetylated LAMB3-mediated FAK/ERK pathway [0.03%]
NAT10通过LAMB3-N4乙酰化介导的FAK/ERK途径调节胰腺导管腺癌的肿瘤进展和免疫微环境
Enhong Chen,Qin Wang,Leisheng Wang et al.
Enhong Chen et al.
Background: N-acetyltransferase 10 (NAT10) was reported to be associated with the immune microenvironment in several cancers. However, it is not known in pancreatic ductal adenocarcinoma (PDAC). This study aimed to elucid...
Susi Zhu,Xu Zhang,Waner Liu et al.
Susi Zhu et al.
Ubiquitination, a key post-translational modification, plays an essential role in tumor biology by regulating fundamental cellular processes, such as metabolism and cell death. Additionally, it interacts with other post-translational modifi...
Single-cell-eQTL mapping in circulating immune cells reveals genetic regulation of response-associated networks in lung cancer immunotherapy [0.03%]
单细胞eQTL在循环免疫细胞中的映射揭示了肺癌免疫疗法中与反应相关网络的遗传调节机制
Hyungtai Sim,Geun-Ho Park,Woong-Yang Park et al.
Hyungtai Sim et al.
Targeting MAN1B1 potently enhances bladder cancer antitumor immunity via deglycosylation of CD47 [0.03%]
靶向作用于MAN1B1通过去糖基化CD47增强膀胱癌的抗肿瘤免疫能力
Jie Zhang,Chen Zhang,Ruichen Zang et al.
Jie Zhang et al.
Background: Only a few bladder cancer patients benefit from anti-programmed cell death protein 1/programmed cell death ligand 1 immunotherapy. The cluster of differentiation 47 (CD47) plays an important role in tumor immu...