The INSPECTOR study: enhanced feasibility for clinical translation of a multi-cancer early detection method based on enzyme-assisted high signal-to-noise ratio sequencing of methylated circulating tumor DNA [0.03%]
INSPECTOR研究：基于酶辅助高信噪比测序甲基化循环肿瘤DNA的多癌症早期检测方法的临床转化可行性增强
Hui-Yan Luo,Wei Wei,Pansong Li et al.
Hui-Yan Luo et al.
Background: Blood-based cell-free DNA (cfDNA) methylation testing has emerged as a promising approach for multi-cancer early detection (MCED), holding the potential to improve cancer survival rates. However, traditional b...
Intranuclear paraspeckle-circular RNA TACC3 assembly forms RNA-DNA hybrids to facilitate MASH-related hepatocellular carcinoma growth in an m6A-dependent manner [0.03%]
m6A依赖的细胞核内寄生speckle-TACC3环形RNA组装形成RNA-DNA杂交体促进肝癌的发生发展
Jingbo Fu,Yanping Wei,Yun Yang et al.
Jingbo Fu et al.
Background: Metabolic dysfunction-associated steatohepatitis (MASH) is anticipated to become the leading cause of hepatocellular carcinoma (HCC). Accumulating evidence indicates that N6-methyladenosine (m6A)-modified circ...
RNA m1A methyltransferase TRMT61A promotes colorectal tumorigenesis by enhancing ONECUT2 mRNA stability and is a potential therapeutic target [0.03%]
RNA m1A甲基转移酶TRMT61A通过增强ONECUT2 mRNA稳定性促进结直肠肿瘤发生并可作为潜在治疗靶点
Xiaoting Zhang,Na Qin,Fenfen Ji et al.
Xiaoting Zhang et al.
Background: The role of N1-methyladenosine (m1A) in cancer is poorly understood. Here we explored the function of RNA methyltransferase TRNA methyltransferase 61A (TRMT61A) in colorectal cancer (CRC) and its potential as ...
Tumor-infiltrating lymphocyte therapy and the mucosal melanoma treatment landscape [0.03%]
肿瘤浸润性淋巴细胞治疗和黏膜黑色素瘤治疗版图
Jennifer Thomas,Max Julve,James Larkin et al.
Jennifer Thomas et al.
CD24 is a promising immunotherapeutic target for enhancing efficacy of third-generation EGFR-TKIs on EGFR-mutated lung cancer [0.03%]
CD24是增强第三代EGFR-TKI对EGFR突变型肺癌疗效的免疫治疗靶点
Jiaqi Liang,Guoshu Bi,Xiaolong Huang et al.
Jiaqi Liang et al.
Background: Third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) show initial efficacy in EGFR-mutated lung cancer, but residual disease persists. This study aimed to investigate clus...
Breaking barriers: the cGAS-STING pathway as a novel frontier in cancer immunotherapy [0.03%]
克服障碍：cGAS-STING信号通路在癌症免疫治疗中的新进展
Yuheng Yan,Ximin Tan,Bin Song et al.
Yuheng Yan et al.
Since its discovery, the cyclic GMP-AMP synthase (cGAS)-stimulator of the interferon gene (STING) signaling pathway has been considered a pivotal component of innate immunity and a promising target for cancer immunotherapy. Beyond its canon...
Efficacy and safety of glecirasib in solid tumors with KRAS G12C mutation: A pooled analysis of two phase I/II trials [0.03%]
针对KRAS G12C突变实体瘤的glecirasib疗效和安全性：两项I/II期试验汇总分析结果
Jian Li,Ting Deng,Yanhong Gu et al.
Jian Li et al.
Background: Glecirasib, an inhibitor of Kirsten rat sarcoma viral oncogene homolog glycine-to-cysteine substitution at codon 12 (KRAS G12C), has exhibited clinical activity in non-small-cell lung cancer (NSCLC) and colore...
Diagnostic performance of a circulating tumor DNA-based blood test compared to fecal immunochemical test in colorectal cancer screening [0.03%]
基于循环肿瘤DNA的血液检测在结直肠癌筛查中的诊断性能与免疫化学粪便隐血试验比较研究
Hermann Brenner,Teresa Seum,Megha Bhardwaj et al.
Hermann Brenner et al.
Mechanism and role of regulated cell death in tumor immunity and immunotherapy [0.03%]
调节性细胞死亡在肿瘤免疫和免疫治疗中的机制和作用
Jingwen Hu,Yan Li,Bingjie Lian et al.
Jingwen Hu et al.
Cancer immune checkpoint inhibitors (ICIs) have brought breakthroughs, but only about one-third of cancer patients benefit from ICIs. In recent years, targeting non-apoptotic regulated cell death (RCD) subtypes, such as ferroptosis, necropt...