Targeting immune-checkpoint inhibitor resistance mechanisms by MEK inhibitor and agonist anti-CD40 antibody combination therapy [0.03%]
通过MEK抑制剂和激动剂抗CD40单克隆抗体联合疗法针对免疫检查点抑制剂的耐药机制
Daniel Baumann,Rienk Offringa
Daniel Baumann
The widespread application of immune-checkpoint blockade (ICB) has resulted in unprecedented response rates in patients with immunogenic cancers, such as melanoma and lung cancer. However, sub-groups of patients with these indications do no...
Tania López-Hernández,Volker Haucke,Tanja Maritzen
Tania López-Hernández
Cellular life is challenged by a multitude of stress conditions, triggered for example by alterations in osmolarity, oxygen or nutrient supply. Hence, cells have developed sophisticated stress responses to cope with these challenges. Some o...
Vera Gorbunova,Masaki Takasugi,Andrei Seluanov
Vera Gorbunova
Hyaluronan is a major non-protein component of extracellular matrix that affects biomechanical properties of tissues and interacts with cell receptors. Hyaluronan is a linear glycosaminoglycan composed of repeating disaccharides of (β, 1-4...
Helena Haque Chowdhury,Robert Zorec
Helena Haque Chowdhury
Exocytosis is a universal process of eukaryotic cells, consisting of fusion between the vesicle and the plasma membranes, leading to the formation of a fusion pore, a channel through which vesicle cargo exits into the extracellular space. I...
Regulation of immune checkpoint blockade efficacy in breast cancer by FIP200: A canonical-autophagy-independent function [0.03%]
FIP200对乳腺癌中免疫检查点阻断疗效的调节：一个非经典自噬功能
Syn Kok Yeo,Jun-Lin Guan
Syn Kok Yeo
Immune checkpoint blockade (ICB) has emerged as a promising therapeutic strategy because of its potential to induce durable therapeutic responses in cancer patients. However, in the case of breast cancer, its application and efficacy has be...
Hyungsoo Kim,Ze&#x;ev A Ronai
Hyungsoo Kim
Protein methyl transferases play critical roles in numerous regulatory pathways that underlie cancer development, progression and therapy-response. Here we discuss the function of PRMT5, a member of the nine-member PRMT family, in controlli...
Exploiting the circuit breaker cancer evolution model in human clear cell renal cell carcinoma [0.03%]
电路断路器癌症进化模型在人类透明细胞肾细胞癌中的应用探索
James J Hsieh,Emily H Cheng
James J Hsieh
The incessant interactions between susceptible humans and their respective macro/microenvironments registered throughout their lifetime result in the ultimate manifestation of individual cancers. With the average lifespan exceeding 50 years...
High mitochondrial calcium levels precede neuronal death in vivo in Alzheimer's disease [0.03%]
阿尔茨海默病中线粒体钙超载先于神经元死亡发生
Maria Calvo-Rodriguez,Brian J Bacskai
Maria Calvo-Rodriguez
Alzheimer's disease (AD), the most common cause of dementia, affects millions of people worldwide. Suggested mechanisms of neurotoxicity in AD include impaired calcium (Ca2+) homeostasis and mitochondrial dysfunction, both contributing to n...
The role of lipids in autophagy and its implication in neurodegeneration [0.03%]
脂质在自噬中的作用及其在神经退行性疾病中的意义
Sergio Hernandez-Diaz,Sandra-Fausia Soukup
Sergio Hernandez-Diaz
Neurodegenerative diseases are, at present, major socio-economic burdens without effective treatments and their increasing prevalence means that these diseases will be a challenge for future generations. Neurodegenerative diseases may diffe...
Immune system activation by natural products and complex fractions: a network pharmacology approach in cancer treatment [0.03%]
天然产物和复方成分的免疫激活作用机制研究及网络药理学抗癌效应探讨
Alejandra Gomez-Cadena,Alfonso Barreto,Susana Fioretino et al.
Alejandra Gomez-Cadena et al.
Natural products and traditional herbal medicine are an important source of alternative bioactive compounds but very few plant-based preparations have been scientifically evaluated and validated for their potential as medical treatments. Ho...