Quantifying replication stress in cancer without proliferation confounding [0.03%]
无需增殖干扰地量化癌症中的复制压力
Philipp Jungk,Maik Kschischo
Philipp Jungk
Replication stress (RS) is a major driver of genomic instability and cancer development through impaired DNA replication that can lead to chromosomal instability (CIN). Although RS is mechanistically linked to CIN, its relationship with cel...
Brittney Adams,Stanislaw Walkowiak,Mohammed K Hankir
Brittney Adams
Removing certain essential amino acids from the diet is known to promote weight loss in rodents via effects on food intake and energy expenditure. Two complementary articles by Varghese et al [Nature 643(8072)] and Lee et al [Nature Metabol...
Xiaohan Chen,Jiaxu Hong,Qihua Le
Xiaohan Chen
The dysfunction of mitochondria, the "energy factories" of cells, not only causes an insufficiency of energy production but also leads to various pathological alterations in cells such as the accumulation of reactive oxygen species, inflamm...
Oxidative stress induces cortical stiffening and cytoskeletal remodelling in pre-apoptotic cancer cells [0.03%]
氧化应激诱导癌细胞凋亡前皮质硬化和细胞骨架重塑
Aiman Jalmukhambetova,Aidana Baltabekova,Aizhan Tolebay et al.
Aiman Jalmukhambetova et al.
An imbalanced production of reactive oxygen species (ROS) is linked to various aspects of cancer development, including cytoskeletal remodelling. However, the relationship between ROS, actin and cellular stiffness remains controversial. Her...
Datopotamab deruxtecan induces hallmarks of immunogenic cell death [0.03%]
Datopotamab_deruxtecan诱导免疫原性细胞死亡标志物出现
Sabrina Forveille,Marion Leduc,Allan Sauvat et al.
Sabrina Forveille et al.
Antibody-drug conjugates (ADCs) offer a strategy for targeted delivery of cytotoxic agents to cancer cells. In this study, we investigated the mechanism of action of datopotamab deruxtecan, an ADC composed of a monoclonal antibody targeting...
Vera Schmiedhofer,Julian Sommersguter-Wagner,Oskar Knittelfelder et al.
Vera Schmiedhofer et al.
High carbohydrate intake, a characteristic of many Western diets, is a major contributor to age-associated pathologies. Here, we explored the molecular consequences of sugar overload during chronological aging in the yeast Saccharomyces cer...
Bax- Bcl-xL interaction dynamics during the progression of cell cycle and cell death using FLIM-FRET [0.03%]
FLIM-FRET在细胞周期和细胞死亡进程中分析Bak-Bcl-xL相互作用动力学
Aman M Halikar,Aneesh Chandrasekharan,Asha Lekshmi et al.
Aman M Halikar et al.
Genetically identical cells in a population show cell-to-cell variability because of fluctuation in transcription, epigenetics, post-translational modifications, and stochastic or extrinsically triggered non-genetic alterations. The change ...
Nrf1 acts as a highly-conserved determinon for maintaining robust redox homeostasis in the eco-evo-devo process of life histories [0.03%]
Nrf1在生命历程的生态进化发育过程中的稳态维持中作为一个高度保守的决定子起作用
Yiguo Zhang,Xi Chen,Meng Wang et al.
Yiguo Zhang et al.
Differential and even opposing functions of two major antioxidant transcription factors Nrf1 and Nrf2 (encoded by Nfe2l1 and Nfe2l2, respectively) are determined by distinctions in their tempospatial positioning, topological repartitioning,...
Pathogenic aspects of fructose consumption in metabolic dysfunction-associated steatotic liver disease (MASLD): A narrative review [0.03%]
果糖消费在代谢功能障碍相关肝脂肪变性疾病(MASLD)发病机制中的作用：叙述性综述
Katharina Burger,Michael Michael Trauner,Ina Bergheim
Katharina Burger
Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly referred to non-alcoholic fatty liver disease (NAFLD), has become a global health concern with a still increasing prevalence. One of the major contributing factors t...
NFAT5: a stress-related transcription factor with multiple functions in health and disease [0.03%]
NFAT5：一种与压力相关的在健康和疾病中具有多种功能的转录因子
Alfredo Domínguez-López,Fátima S Magaña-Guerrero,Beatriz Buentello-Volante et al.
Alfredo Domínguez-López et al.
Nuclear factor of activated T cells 5 (NFAT5) is a transcription factor within the Rel family, primarily recognized for its role in cellular adaptation to osmotic stress, particularly in hypertonic and hyperosmotic environments. Beyond osmo...