Mitochondrial dynamics links PINCH-1 signaling to proline metabolic reprogramming and tumor growth [0.03%]
线粒体动态连接PINCH-1信号转导与脯氨酸代谢重编程及肿瘤生长之间的联系
Ling Guo,Chuanyue Wu
Ling Guo
Proline metabolism is critical for cellular response to microenvironmental stress in living organisms across different kingdoms, ranging from bacteria, plants to animals. In bacteria and plants, proline is known to accrue in response to osm...
To promote or inhibit glioma progression, that is the question for IL-33 [0.03%]
促进还是抑制？白细胞介素33在胶质瘤进展中的作用 질문的答案：IL-33在胶质瘤进展中是促进还是抑制？
Stephen M Robbins,Donna L Senger
Stephen M Robbins
IL-33, a member of the IL-1 cytokine family has been shown to play a dual role within the body. First IL-33, similar to other IL-1 family members, is a secreted cytokine that binds to the cell surface receptor ST2 to induce a number of cell...
Improving glucose and lipids metabolism: drug development based on bile acid related targets [0.03%]
基于胆汁酸靶点的改善糖脂代谢药物研发进展
Hanchen Shen,Lili Ding,Mehdi Baig et al.
Hanchen Shen et al.
Bariatric surgery is one of the most effective treatment options for severe obesity and its comorbidities. However, it is a major surgery that poses several side effects and risks which impede its clinical use. Therefore, it is urgent to de...
AMPK maintains TCA cycle through sequential phosphorylation of PDHA to promote tumor metastasis [0.03%]
AMPK通过依次磷酸化PDHA维持TCA循环以促进肿瘤转移
Zhen Cai,Danni Peng,Hui-Kuan Lin
Zhen Cai
Cancer represents the leading public health problem throughout the world. Globally, about one out of six deaths is related to cancer, which is largely due to the metastatic lesions. However, there are no effective strategies for targeting c...
Joseph Menassa,Christina Nedeva,Corey Pollock et al.
Joseph Menassa et al.
Sepsis and its impact on human health can be traced back to 1000 BC and continues to be a major health burden today. It causes about 11 million deaths world-wide of which, more than a third are due to neonatal sepsis. There is no effective ...
A sympathetic gut connection drives the metabolic benefits of Roux-en-Y gastric bypass [0.03%]
肠道的这种同情连接驱动了Roux-en-Y胃旁路手术的代谢益处
Mohammed K Hankir
Mohammed K Hankir
Surgery is regarded by many as the go-to treatment option for severe obesity; yet how physically altering the gastrointestinal tract produces such striking results on body weight and overall metabolic health is poorly understood. In a recen...
A mutant p53/Hif1α/miR-30d axis reprograms the secretory pathway promoting the release of a prometastatic secretome [0.03%]
一个突变的p53/Hif1α/miR-30d轴重新编程分泌途径以促进释放一种促转移分泌组
Valeria Capaci,Fiamma Mantovani,Giannino Del Sal
Valeria Capaci
TP53 missense mutations are frequent driver events during tumorigenesis. The majority of TP53 mutations are missense and occur within the DNA binding domain of p53, leading to expression of mutant p53 (mut-p53) proteins that not only lose t...
Shailendra Kumar Dhar Dwivedi,Geeta Rao,Anindya Dey et al.
Shailendra Kumar Dhar Dwivedi et al.
Uterine carcinosarcoma (UCS) is a relatively infrequent, but extremely aggressive endometrial malignancy. Although surgery and chemotherapy have improved outcomes, overall survival (OS) remains dismal due to the lack of targeted therapy and...
Targeting immune-checkpoint inhibitor resistance mechanisms by MEK inhibitor and agonist anti-CD40 antibody combination therapy [0.03%]
通过MEK抑制剂和激动剂抗CD40单克隆抗体联合疗法针对免疫检查点抑制剂的耐药机制
Daniel Baumann,Rienk Offringa
Daniel Baumann
The widespread application of immune-checkpoint blockade (ICB) has resulted in unprecedented response rates in patients with immunogenic cancers, such as melanoma and lung cancer. However, sub-groups of patients with these indications do no...
Tania López-Hernández,Volker Haucke,Tanja Maritzen
Tania López-Hernández
Cellular life is challenged by a multitude of stress conditions, triggered for example by alterations in osmolarity, oxygen or nutrient supply. Hence, cells have developed sophisticated stress responses to cope with these challenges. Some o...