Ribosome traffic jam in neurodegeneration: decoding hurdles in Huntington disease [0.03%]
神经退行性病变中的核糖体交通堵塞：亨廷顿舞蹈病的解码障碍
Srinivasa Subramaniam
Srinivasa Subramaniam
A ribosome typically moves at a particular rate on a given mRNA transcript to decode the nucleic acid information required to synthesize proteins. The speed and directionality of the ribosome movements during mRNA translation are determined...
The evolution of the concept of stress and the framework of the stress system [0.03%]
应激的概念演变及应激系统的框架理论
Siyu Lu,Fang Wei,Guolin Li
Siyu Lu
Stress is a central concept in biology and has now been widely used in psychological, physiological, social, and even environmental fields. However, the concept of stress was cross-utilized to refer to different elements of the stress syste...
Coping with the calcium overload caused by cell injury: ER to the rescue [0.03%]
细胞损伤后的钙离子过载及其应急机制：内质网的保护作用
Goutam Chandra,Davi A G Mázala,Jyoti K Jaiswal
Goutam Chandra
Cells maintain their cytosolic calcium (Ca2+) in nanomolar range and use controlled increase in Ca2+ for intracellular signaling. With the extracellular Ca2+ in the millimolar range, there is a steep Ca2+ gradient across the plasma membrane...
Xiao-Zheng Liu,Line Pedersen,Nils Halberg
Xiao-Zheng Liu
Obesity is epidemiologically linked to 13 forms of cancer. The local and systemic obese environment is complex and likely affect tumors through multiple avenues. This includes modulation of cancer cell phenotypes and the composition of the ...
Inhibitory DAMPs in immunogenic cell death and its clinical implications [0.03%]
免疫性细胞死亡中的抑制性损伤相关分子及其临床意义
Kazukuni Hayashi,Fotis Nikolos,Keith S Chan
Kazukuni Hayashi
Dying (or dead) cells are increasingly recognized to impose significant biological influence within their tissues of residence-exerting paracrine effects through proteins and metabolites that are expressed or secreted during cellular demise...
Roles of phosphatidyl inositol 3 kinase gamma (PI3Kγ) in respiratory diseases [0.03%]
磷脂酰肌醇-3-激酶γ(PI3Kγ)在呼吸系统疾病中的作用
Valentina Sala,Angela Della Sala,Alessandra Ghigo et al.
Valentina Sala et al.
Phosphatidyl inositol 3 kinase gamma (PI3Kγ) is expressed in all the cell types that are involved in airway inflammation and disease, including not only leukocytes, but also structural cells, where it is expressed at very low levels under ...
Andreas Zimmermann,Didac Carmona-Gutierrez,Frank Madeo
Andreas Zimmermann
The polyamine spermidine is essential for protein translation in eukaryotes, both as a substrate for the hypusination of the translation initiation factor eIF5A as well as general translational fidelity. Dwindling spermidine levels during a...
Targeting FBXO44/SUV39H1 elicits tumor cell-specific DNA replication stress and viral mimicry [0.03%]
靶向FBXO44/SUV39H1可在肿瘤细胞中特异诱导DNA复制应力及病毒模拟反应
Jia Z Shen,Charles Spruck
Jia Z Shen
Repetitive elements (REs) are normally transcriptionally silenced in somatic cells by repressive epigenetic modifications, which are thought to include DNA methylation and histone modifications such as deacetylation, H3K9me3, and H4K20me3. ...
The OFD1 protein is a novel player in selective autophagy: another tile to the cilia/autophagy puzzle [0.03%]
OFD1蛋白参与选择性自噬作用：纤毛/自噬难题的另一块拼图
Manuela Morleo,Brunella Franco
Manuela Morleo
The autophagy-lysosomal pathway is one of the main degradative routes which cells use to balance sources of energy. A number of proteins orchestrate the formation of autophagosomes, membranous organelles instrumental in autophagy. Selective...
Innate RIG-I signaling restores antigen presentation in tumors and overcomes T cell resistance [0.03%]
内在的RIG-I信号恢复肿瘤中的抗原呈递并克服T细胞抵抗
Beatrice Thier,Annette Paschen
Beatrice Thier
In recent years, therapy with immune modulating antibodies, termed immune checkpoint blockade (ICB), has revolutionized the treatment of advanced metastatic melanoma, yielding long-lasting clinical responses in a subgroup of patients. But d...