Rethinking the bioavailability and cellular transport properties of S-adenosylmethionine [0.03%]
重新思考腺苷蛋氨酸的生物利用度和细胞转运特性
Yudong Sun,Jason W Locasale
Yudong Sun
S-adenosylmethionine (SAM) is a versatile metabolite that participates in a wide range of reactions such as methylation and transsulfuration. These capabilities allow SAM to influence cellular processes such as gene expression and redox bal...
p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway [0.03%]
P38通过TSC-mTORC1信号通路调节肿瘤抑制因子PDCD4
Clarissa Braun,Karl Katholnig,Christopher Kaltenecker et al.
Clarissa Braun et al.
Programmed cell death protein 4 (PDCD4) exerts critical functions as tumor suppressor and in immune cells to regulate inflammatory processes. The phosphoinositide 3-kinase (PI3K) promotes degradation of PDCD4 via mammalian target of rapamyc...
GRASPing the unconventional secretory machinery to bridge cellular stress signaling to the extracellular proteome [0.03%]
抓住非传统分泌机制以连接细胞应激信号与胞外蛋白质组的关系
Constantinos Demetriades,Julian Nüchel,Markus Plomann
Constantinos Demetriades
Cellular adaptation to stress is a crucial homeostatic process for survival, metabolism, physiology, and disease. Cells respond to stress stimuli (e.g., nutrient starvation, growth factor deprivation, hypoxia, low energy, etc.) by changing ...
Giusy Battilana,Francesca Zanconato,Stefano Piccolo
Giusy Battilana
Dysregulated gene expression is intrinsic to cell transformation, tumorigenesis and metastasis. Cancer-specific gene-expression profiles stem from gene regulatory networks fueled by genetic and epigenetic defects, and by abnormal signals of...
Macroautophagy and normal aging of the nervous system: Lessons from animal models [0.03%]
自噬作用与神经系统正常老化：动物模型给我们的启示
Emmanouela Kallergi,Vassiliki Nikoletopoulou
Emmanouela Kallergi
Aging represents a cumulative form of cellular stress, which is thought to challenge many aspects of proteostasis. The non-dividing, long-lived neurons are particularly vulnerable to stress, and, not surprisingly, even normal aging is highl...
Ebony A Monson,Karla J Helbig
Ebony A Monson
When a host cell is infected by a virus, it activates the innate immune response, setting off a cascade of signalling events leading to the production of an antiviral response. This immune response is typically robust and in general works w...
Suresh Kumar,Jingyue Jia,Vojo Deretic
Suresh Kumar
The yeast Atg8 protein and its paralogs in mammals, mammalian Atg8s (mAtg8s), have been primarily appreciated for their participation in autophagy. However, lipidated mAtg8s, including the most frequently used autophagosomal membrane marker...
Jian-Kang Zhou,Xin Fan,Jian Cheng et al.
Jian-Kang Zhou et al.
PDLIM1, a member of the PDZ-LIM family, is a cytoskeletal protein and functions as a platform to form distinct protein complexes, thus participating in multiple physiological processes such as cytoskeleton regulation and synapse formation. ...
Towards a better understanding of the neuro-developmental role of autophagy in sickness and in health [0.03%]
从生病到健康 自噬在神经发育中的作用不容小觑
Juan Zapata-Muñoz,Beatriz Villarejo-Zori,Pablo Largo-Barrientos et al.
Juan Zapata-Muñoz et al.
Autophagy is a critical cellular process by which biomolecules and cellular organelles are degraded in an orderly manner inside lysosomes. This process is particularly important in neurons: these post-mitotic cells cannot divide or be easil...
Elevated plasma levels of the appetite-stimulator ACBP/DBI in fasting and obese subjects [0.03%]
饥饿和肥胖者中食欲刺激物ACBP/DBI的血浆水平升高
Sijing Li,Adrien Joseph,Isabelle Martins et al.
Sijing Li et al.
Eukaryotic cells release the phylogenetically ancient protein acyl coenzyme A binding protein (ACBP, which in humans is encoded by the gene DBI, diazepam binding inhibitor) upon nutrient deprivation. Accordingly, mice that are starved for o...