A pathological role of the Hsp40 protein Ydj1/DnaJA1 in models of Alzheimer's disease [0.03%]
Hsp40蛋白Ydj1/DnaJA1在阿尔茨海默病模型中的病理作用
Jelena Tadic,Julia Ring,Andrea Jerkovic et al.
Jelena Tadic et al.
Alzheimer's disease (AD) is the most common form of dementia with millions of people affected worldwide. Pathophysiological manifestations of AD include the extracellular accumulation of amyloid beta (Abeta) pep-tides, products of the prote...
Mahmoud Abdellatif,Tobias Eisenberg,Alexander Martin Heberle et al.
Mahmoud Abdellatif et al.
Phosphoinositide 3-kinase (PI3K) is a key component of the insulin signaling pathway that controls cellular me-tabolism and growth. Loss-of-function mutations in PI3K signaling and other downstream effectors of the insulin signaling pathway...
Unraveling the surface proteomic profile of multiple myeloma to reveal new immunotherapeutic targets and markers of drug resistance [0.03%]
揭秘多发性骨髓瘤表面蛋白质组以揭示新的免疫治疗靶点及耐药标志物
Bonell Patiño-Escobar,Ian D Ferguson,Arun P Wiita
Bonell Patiño-Escobar
The cell surface proteome ("surfaceome") serves as the interface between diseased cells and their local microenvironment. In cancer, this compartment is critical not only for defining tumor biology but also serves as a rich source of potent...
Xiang Zeng,Dongling Liu,Xia Huo et al.
Xiang Zeng et al.
Pyroptosis is a proinflammatory form of programmed cell death in response to inflammation. It involves in the pathogenesis and outcomes of atherosclerosis characterized by NLRP3 inflammasome assembly, membrane pore formation, cell swelling,...
COX-2 upregulation by tumour cells post-chemotherapy fuels the immune evasive dark side of cancer inflammation [0.03%]
化疗后的肿瘤细胞通过诱导COX-2上调点燃癌症炎症免疫逃避的“暗黑”模式
Charlotte R Bell,Santiago Zelenay
Charlotte R Bell
Cytotoxic therapies, such as chemotherapy and radiotherapy, are mainstays of cancer treatment for both early and unresectable, advanced disease. In addition to debulking the tumour mass through direct killing of proliferating tumour cells, ...
Could TNF-antagonists be a novel treatment strategy for BPH patients? [0.03%]
肿瘤坏死因子拮抗剂可能是治疗前列腺增生患者的新策略吗？
Renee E Vickman,Omar E Franco,Simon W Hayward
Renee E Vickman
Tumor necrosis factor (TNF) is widely recognized as a pivotal player in both systemic and local inflammatory processes. Due to the critical role this molecule has in driving both chronic and acute inflammation, it was among the earliest the...
Mohammed K Hankir
Mohammed K Hankir
Brown adipocytes react to temperature and nutritional challenges by ramping up their metabolism and generating heat. This adaptation to changes in the environment is crucial for defending organismal homeostasis, but is impaired in obesity a...
COX4-1 promotes mitochondrial supercomplex assembly and limits reactive oxide species production in radioresistant GBM [0.03%]
COX4-1促进放射耐药胶质母细胞瘤线粒体超复合物装配并限制反应性氧化物生成
Claudia R Oliva,Md Yousuf Ali,Susanne Flor et al.
Claudia R Oliva et al.
Glioblastoma (GBM) is a fatal disease with recurrences often associated with radioresistance. Although often effective at treating newly diagnosed GBM, increasing evidence suggests that radiotherapy-induced alterations in tumor metabolism p...
Ana Kasapi,Antigoni Triantafyllopoulou
Ana Kasapi
Tissue macrophages arise from yolk sac, fetal liver and hematopoietic progenitors and adopt diverse transcriptional programs and phenotypes, instructed by their microenvironment. In chronic inflammation, such as in chronic infections, autoi...
MYCN upregulates the transsulfuration pathway to suppress the ferroptotic vulnerability in MYCN-amplified neuroblastoma [0.03%]
MYCN通过上调氨基酸跨磺化途径来抑制MYCN扩增的神经母细胞瘤中铁死亡引发的细胞脆弱性
Konstantinos V Floros,Ayesha T Chawla,Mia O Johnson-Berro et al.
Konstantinos V Floros et al.
Ferroptosis is an iron-dependent, oxidative form of cell death that is countered mainly by glutathione peroxidase 4 (GPX4) and the production of glutathione (GSH), which is formed from cysteine. The identification of the cancers that may be...