Sensitive, non-immunogenic in vivo imaging of cancer metastases and immunotherapy response [0.03%]
灵敏且非免疫原性的体内成像技术在癌症转移和免疫治疗反应中的应用
Joseph R Merrill,Alessandra Inguscio,Taemoon Chung et al.
Joseph R Merrill et al.
Non-invasive imaging of tumors expressing reporter transgenes is a popular preclinical method for studying tumor development and response to therapy in vivo due to its ability to distinguish signal from tumors over background noise. However...
Chromatin assembly factor-1 preserves genome stability in ctf4 Δ cells by promoting sister chromatid cohesion [0.03%]
染色质装配因子-1通过促进姐妹染色单体粘连来保护ctf4 Δ细胞的基因组稳定性
Nagham Ghaddar,Pierre Luciano,Vincent Géli et al.
Nagham Ghaddar et al.
Chromatin assembly and the establishment of sister chromatid cohesion are intimately connected to the progression of DNA replication forks. Here we examined the genetic interaction between the heterotrimeric chromatin assembly factor-1 (CAF...
Molecular targets of spermidine: implications for cancer suppression [0.03%]
spermidine的分子靶点：对癌症抑制的意义
Andreas Zimmermann,Sebastian J Hofer,Frank Madeo
Andreas Zimmermann
Spermidine is a ubiquitous, natural polyamine with geroprotective features. Supplementation of spermidine extends the lifespan of yeast, worms, flies, and mice, and dietary spermidine intake correlates with reduced human mortality. However,...
Nermina Malanovic,Djenana Vejzovic
Nermina Malanovic
The continuous use of antibiotics is associated with the spread of antimicrobial resistances and the not yet clear link to cancer development. Many conventional antibiotics have already shown different effects on a variety of cancer types r...
CRISPR-activation screen identified potassium channels for protection against mycotoxins through cell cycle progression and mitochondrial function [0.03%]
利用细胞周期进程和线粒体功能筛选出保护酿酒酵母免受霉菌毒素侵害的钾通道的CRISPR激活技术筛查
Yulong Tang,Simeng Liao,Zhuyuan Nie et al.
Yulong Tang et al.
Zearalenone (ZEA) exposure has carcinogenic effects on human and animal health by exhibiting intestinal, hepatic, and renal toxicity. At present, the underlying mechanisms on how ZEA induces apoptosis and damage to tissues still remain uncl...
Chronic heart failure following hemorrhagic myocardial infarction: mechanism, treatment and outlook [0.03%]
出血性心肌梗死后慢性心力衰竭：机制、治疗及预后
Shing Fai Chan,Keyur Vora,Rohan Dharmakumar
Shing Fai Chan
Myocardial infarction (MI), the blockage of arterial blood supply of the heart, is among the most common causes of death worldwide. Even when patients receive immediate treatment by re-opening blocked arteries, they often develop chronic he...
Macrolide antibiotics activate the integrated stress response and promote tumor proliferation [0.03%]
大环内酯类抗生素激活综合应力反应并促进肿瘤增殖
Xin Yu,Ai-Ling Tian,Ping Wang et al.
Xin Yu et al.
Macrolide antibiotics are widely used antibacterial agents that are associated with autophagy inhibition. This study aimed to investigate the association between macrolide antibiotics and malignant tumors, as well as the effect on autophagy...
Safae Terrisse,Laurence Zitvogel,Guido Kroemer
Safae Terrisse
Recent observations indicate that the pathogenesis and prognosis of hormone-receptor breast cancer is not only dictated by the properties of the malignant cells but also by immune and microbial parameters. Thus, the immunosurveillance syste...
Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death [0.03%]
聚腺苷二磷酸核糖聚合酶-1及其在细胞生死中的模棱两可作用
Maria Castedo,Antoine Lafarge,Guido Kroemer
Maria Castedo
The deletion of the gene coding for poly(ADP-ribose) polymerase-1 (PARP1) or its pharmacological inhibition protects mice against cerebral ischemia and Parkinson's disease. In sharp contrast, PARP1 inhibitors are in clinical use for the era...
Niki Ktena,Stefanos Ioannis Kaplanis,Irina Kolotuev et al.
Niki Ktena et al.
(Macro)autophagy is a major lysosome-dependent degradation mechanism which engulfs, removes and recycles unwanted cytoplasmic material, including damaged organelles and toxic protein aggregates. Although a few studies implicate autophagy in...