Molecular targets of spermidine: implications for cancer suppression [0.03%]
spermidine的分子靶点：对癌症抑制的意义
Andreas Zimmermann,Sebastian J Hofer,Frank Madeo
Andreas Zimmermann
Spermidine is a ubiquitous, natural polyamine with geroprotective features. Supplementation of spermidine extends the lifespan of yeast, worms, flies, and mice, and dietary spermidine intake correlates with reduced human mortality. However,...
Nermina Malanovic,Djenana Vejzovic
Nermina Malanovic
The continuous use of antibiotics is associated with the spread of antimicrobial resistances and the not yet clear link to cancer development. Many conventional antibiotics have already shown different effects on a variety of cancer types r...
CRISPR-activation screen identified potassium channels for protection against mycotoxins through cell cycle progression and mitochondrial function [0.03%]
利用细胞周期进程和线粒体功能筛选出保护酿酒酵母免受霉菌毒素侵害的钾通道的CRISPR激活技术筛查
Yulong Tang,Simeng Liao,Zhuyuan Nie et al.
Yulong Tang et al.
Zearalenone (ZEA) exposure has carcinogenic effects on human and animal health by exhibiting intestinal, hepatic, and renal toxicity. At present, the underlying mechanisms on how ZEA induces apoptosis and damage to tissues still remain uncl...
Chronic heart failure following hemorrhagic myocardial infarction: mechanism, treatment and outlook [0.03%]
出血性心肌梗死后慢性心力衰竭：机制、治疗及预后
Shing Fai Chan,Keyur Vora,Rohan Dharmakumar
Shing Fai Chan
Myocardial infarction (MI), the blockage of arterial blood supply of the heart, is among the most common causes of death worldwide. Even when patients receive immediate treatment by re-opening blocked arteries, they often develop chronic he...
Macrolide antibiotics activate the integrated stress response and promote tumor proliferation [0.03%]
大环内酯类抗生素激活综合应力反应并促进肿瘤增殖
Xin Yu,Ai-Ling Tian,Ping Wang et al.
Xin Yu et al.
Macrolide antibiotics are widely used antibacterial agents that are associated with autophagy inhibition. This study aimed to investigate the association between macrolide antibiotics and malignant tumors, as well as the effect on autophagy...
Safae Terrisse,Laurence Zitvogel,Guido Kroemer
Safae Terrisse
Recent observations indicate that the pathogenesis and prognosis of hormone-receptor breast cancer is not only dictated by the properties of the malignant cells but also by immune and microbial parameters. Thus, the immunosurveillance syste...
Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death [0.03%]
聚腺苷二磷酸核糖聚合酶-1及其在细胞生死中的模棱两可作用
Maria Castedo,Antoine Lafarge,Guido Kroemer
Maria Castedo
The deletion of the gene coding for poly(ADP-ribose) polymerase-1 (PARP1) or its pharmacological inhibition protects mice against cerebral ischemia and Parkinson's disease. In sharp contrast, PARP1 inhibitors are in clinical use for the era...
Niki Ktena,Stefanos Ioannis Kaplanis,Irina Kolotuev et al.
Niki Ktena et al.
(Macro)autophagy is a major lysosome-dependent degradation mechanism which engulfs, removes and recycles unwanted cytoplasmic material, including damaged organelles and toxic protein aggregates. Although a few studies implicate autophagy in...
A pathological role of the Hsp40 protein Ydj1/DnaJA1 in models of Alzheimer's disease [0.03%]
Hsp40蛋白Ydj1/DnaJA1在阿尔茨海默病模型中的病理作用
Jelena Tadic,Julia Ring,Andrea Jerkovic et al.
Jelena Tadic et al.
Alzheimer's disease (AD) is the most common form of dementia with millions of people affected worldwide. Pathophysiological manifestations of AD include the extracellular accumulation of amyloid beta (Abeta) pep-tides, products of the prote...
Mahmoud Abdellatif,Tobias Eisenberg,Alexander Martin Heberle et al.
Mahmoud Abdellatif et al.
Phosphoinositide 3-kinase (PI3K) is a key component of the insulin signaling pathway that controls cellular me-tabolism and growth. Loss-of-function mutations in PI3K signaling and other downstream effectors of the insulin signaling pathway...