Saliva, a molecular reflection of the human body? Implications for diagnosis and treatment [0.03%]
唾液：人体的分子反映？对诊断和治疗的意义
Vincent Géli,Norbert Nabet
Vincent Géli
For many diseases, and cancer in particular, early diagnosis allows a wider range of therapies and a better disease management. This has led to improvements in diagnostic procedures, most often based on tissue biopsies or blood samples. Oth...
CircRNA regulates the liquid-liquid phase separation of ATG4B, a novel strategy to inhibit cancer metastasis? [0.03%]
circRNA调控ATG4B液-液相分离，抑制癌症转移的新策略？
Ziyuan Guo,Yang Chen,Yaran Wu et al.
Ziyuan Guo et al.
Anoikis is a common programmed death for most of detached cells, but cancer cells can obtain anoikis resistance to facilitate their distant metastasis through the circulation system. Researches have indicated that enhanced autophagic flux a...
Pathogenic hyperactivation of mTORC1 by cytoplasmic EP300 in Hutchinson-Gilford progeria syndrome [0.03%]
Hutchinson-Gilford早老症小鼠模型中EP300介导的mTORC1过度活化导致病理损伤
Lucille Ferret,Guido Kroemer,Mojgan Djavaheri-Mergny
Lucille Ferret
In a recent issue in Nature Cell Biology, Sung Min Son et al. unveil a novel layer in the regulation of the mTORC1/autophagy axis by EP300 which can undergo nucleocytoplasmic shuttling in response to alterations in nutrient availability. Th...
MiR-200c reprograms fibroblasts to recapitulate the phenotype of CAFs in breast cancer progression [0.03%]
MiR-200c重新编程成纤维细胞以再现乳腺癌进展中CAFs的表型
Zhao Lin,Megan E Roche,Víctor Díaz-Barros et al.
Zhao Lin et al.
Mesenchymal-epithelial plasticity driving cancer progression in cancer-associated fibroblasts (CAFs) is undetermined. This work identifies a subgroup of CAFs in human breast cancer exhibiting mesenchymal-to-epithelial transition (MET) or ep...
Carlos López-Otín,Guido Kroemer
Carlos López-Otín
The eight biological hallmarks of health that we initially postulated (Cell. 2021 Jan 7;184(1):33-63) include features of spatial compartmentalization (integrity of barriers, containment of local perturbations), maintenance of homeostasis o...
Chiara Annunziata,Francesca Castoldi,Schlegel Jan et al.
Chiara Annunziata et al.
The increased burden of senescent cells is as a well-established hallmark of aging and age-related diseases. This finding sparked significant interest in the identification of molecules capable of selectively eliminating senescent cells, so...
STING-driven activation of T cells: relevance for the adoptive cell therapy of cancer [0.03%]
STING驱动的T细胞激活：适应性细胞治疗癌症的相关性
Fabian Richter,Christophe Paget,Lionel Apetoh
Fabian Richter
Adoptive cell therapy (ACT) can successfully treat hematopoietic cancers but lacks efficacy against solid tumors. This is due to insufficient T cell infiltration, high tumor heterogeneity, frequent antigen loss with subsequent tumor escape,...
Mohammed K Hankir
Mohammed K Hankir
Bariatric surgeries like vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass (RYGB) cause well-established shifts in the gut microbiota, but how this contributes to their unique metabolic benefits is poorly understood. Jin et al ...
Sensitive, non-immunogenic in vivo imaging of cancer metastases and immunotherapy response [0.03%]
灵敏且非免疫原性的体内成像技术在癌症转移和免疫治疗反应中的应用
Joseph R Merrill,Alessandra Inguscio,Taemoon Chung et al.
Joseph R Merrill et al.
Non-invasive imaging of tumors expressing reporter transgenes is a popular preclinical method for studying tumor development and response to therapy in vivo due to its ability to distinguish signal from tumors over background noise. However...
Chromatin assembly factor-1 preserves genome stability in ctf4 Δ cells by promoting sister chromatid cohesion [0.03%]
染色质装配因子-1通过促进姐妹染色单体粘连来保护ctf4 Δ细胞的基因组稳定性
Nagham Ghaddar,Pierre Luciano,Vincent Géli et al.
Nagham Ghaddar et al.
Chromatin assembly and the establishment of sister chromatid cohesion are intimately connected to the progression of DNA replication forks. Here we examined the genetic interaction between the heterotrimeric chromatin assembly factor-1 (CAF...