Datopotamab deruxtecan induces hallmarks of immunogenic cell death [0.03%]
Datopotamab_deruxtecan诱导免疫原性细胞死亡标志物出现
Sabrina Forveille,Marion Leduc,Allan Sauvat et al.
Sabrina Forveille et al.
Antibody-drug conjugates (ADCs) offer a strategy for targeted delivery of cytotoxic agents to cancer cells. In this study, we investigated the mechanism of action of datopotamab deruxtecan, an ADC composed of a monoclonal antibody targeting...
Vera Schmiedhofer,Julian Sommersguter-Wagner,Oskar Knittelfelder et al.
Vera Schmiedhofer et al.
High carbohydrate intake, a characteristic of many Western diets, is a major contributor to age-associated pathologies. Here, we explored the molecular consequences of sugar overload during chronological aging in the yeast Saccharomyces cer...
Bax- Bcl-xL interaction dynamics during the progression of cell cycle and cell death using FLIM-FRET [0.03%]
FLIM-FRET在细胞周期和细胞死亡进程中分析Bak-Bcl-xL相互作用动力学
Aman M Halikar,Aneesh Chandrasekharan,Asha Lekshmi et al.
Aman M Halikar et al.
Genetically identical cells in a population show cell-to-cell variability because of fluctuation in transcription, epigenetics, post-translational modifications, and stochastic or extrinsically triggered non-genetic alterations. The change ...
Nrf1 acts as a highly-conserved determinon for maintaining robust redox homeostasis in the eco-evo-devo process of life histories [0.03%]
Nrf1在生命历程的生态进化发育过程中的稳态维持中作为一个高度保守的决定子起作用
Yiguo Zhang,Xi Chen,Meng Wang et al.
Yiguo Zhang et al.
Differential and even opposing functions of two major antioxidant transcription factors Nrf1 and Nrf2 (encoded by Nfe2l1 and Nfe2l2, respectively) are determined by distinctions in their tempospatial positioning, topological repartitioning,...
Pathogenic aspects of fructose consumption in metabolic dysfunction-associated steatotic liver disease (MASLD): A narrative review [0.03%]
果糖消费在代谢功能障碍相关肝脂肪变性疾病(MASLD)发病机制中的作用：叙述性综述
Katharina Burger,Michael Michael Trauner,Ina Bergheim
Katharina Burger
Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly referred to non-alcoholic fatty liver disease (NAFLD), has become a global health concern with a still increasing prevalence. One of the major contributing factors t...
NFAT5: a stress-related transcription factor with multiple functions in health and disease [0.03%]
NFAT5：一种与压力相关的在健康和疾病中具有多种功能的转录因子
Alfredo Domínguez-López,Fátima S Magaña-Guerrero,Beatriz Buentello-Volante et al.
Alfredo Domínguez-López et al.
Nuclear factor of activated T cells 5 (NFAT5) is a transcription factor within the Rel family, primarily recognized for its role in cellular adaptation to osmotic stress, particularly in hypertonic and hyperosmotic environments. Beyond osmo...
Probiotics and mediterranean diet for breast cancer management and prevention? [0.03%]
益生菌和地中海饮食能用于乳腺癌的预防和治疗吗？
Ehssan A Sharif-Askari,Khadija M Atoui,Ali K Mteyrek et al.
Ehssan A Sharif-Askari et al.
The human gut microbiota, a diverse community of beneficial normal flora microorganisms, significantly influences physiological function and the immune response. Various microbiota strains have shown promise in supporting clinical treatment...
Cold exposure reinstates NAD+ levels and attenuates hepatocellular carcinoma [0.03%]
冷暴露恢复NAD+水平并抑制肝细胞癌
Tatiana P Grazioso,Maria Del Mar Rigual,Cristian Perna et al.
Tatiana P Grazioso et al.
Cold exposure has been historically used for medicinal purposes, but its benefits and associated mechanisms in mammalian organisms still remain unclear. Here, we explore the chemoprotective properties of cold temperature using a mouse model...
Endogenous plasma resuspension of peripheral blood mononuclear cells prevents preparative-associated stress that modifies polyA-enriched RNA responses to subsequent acute stressors [0.03%]
内源性血浆重悬外周血单个核细胞可防止预处理相关的压力从而修改多腺苷二磷酸核糖聚合酶富集的rna对随后急性应激源的反应
Dongyang Li,Karina Al-Dahleh,Daniel A Murphy et al.
Dongyang Li et al.
Human peripheral blood mononuclear cells (PBMCs) are used to examine biological processes and disease, when basal variability in cellular activation and splicing is described and unexplained. Using isolation systems that maintained buffy co...
Neuroglobin-enriched secretome provides neuroprotection against hydrogen peroxide and mitochondrial toxin-induced cellular stress [0.03%]
富含神经球蛋白的分泌组可提供过氧化氢和线粒体毒物诱导的细胞应激的神经保护作用
Giovanna Bastari,Virginia Solar Fernandez,Maurizio Muzzi et al.
Giovanna Bastari et al.
Aberrant response to physiological cell stress is part of the mechanisms underlying the development of diverse human diseases, including neuropathologies. Neuroglobin (NGB), an intracellular monomeric globin, has gained attention for its ro...