Niels Ødum
Niels Ødum
Shamaila Munir,Mia Thorup Lundsager,Mia Aabroe Jørgensen et al.
Shamaila Munir et al.
PD-L1-specific T cells are a natural part of the T-cell repertoire in humans. Hence, we have previously described spontaneous CD8+ and CD4+ T-cell reactivity against PD-L1 in the peripheral blood of patients with various cancers as well as ...
Acyl-CoA-binding protein (ACBP): the elusive 'hunger factor' linking autophagy to food intake [0.03%]
酰基辅酶a结合蛋白（ACBP）：难以捉摸的“饥饿因子”，将自噬与摄食行为联系在一起
José Manuel Bravo-San Pedro,Valentina Sica,Frank Madeo et al.
José Manuel Bravo-San Pedro et al.
The best-known appetite-regulating factors identified in rodents are leptin, an appetite inhibitor, and ghrelin, an appetite stimulator. Rare cases of loss-of-functions mutations affecting leptin and its receptor, as well as polymorphisms c...
Seila Lorenzo-Herrero,Christian Sordo-Bahamonde,Segundo González et al.
Seila Lorenzo-Herrero et al.
Cancer development is tightly controlled by effector immune responses that recognize and eliminate malignantly transformed cells. Nonetheless, certain immune subsets, such as tumor-associated macrophages, have been described to promote tumo...
Myelopoiesis, metabolism and therapy: a crucial crossroads in cancer progression [0.03%]
髓系细胞、代谢和治疗：癌症进展中的关键交叉点
Antonio Sica,Valentina Guarneri,Alessandra Gennari
Antonio Sica
Cancers promote immunological stresses that induce alterations of the myelopoietic output, defined as emergency myelopoiesis, which lead to the generation of different myeloid populations endowed with tumor-promoting activities. New evidenc...
Unraveling the molecular principles by which ceramides commit cells to death [0.03%]
解开鞘氨醇脂类通过何种分子机制诱导细胞凋亡原理
Shashank Dadsena,Dina G Hassan,Joost C M Holthuis
Shashank Dadsena
Ceramides are central intermediates of sphingolipid metabolism that can activate a variety of tumor suppressive cellular programs, including cell cycle arrest, senescence and apoptosis. Indeed, perturbations in ceramide generation and turno...
Yanyan Huai,Yushan Zhang,Xunhao Xiong et al.
Yanyan Huai et al.
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest solid cancers with dismal prognosis. Several mechanisms that are mainly responsible for aggressiveness and therapy resistance of PDAC cells include epithelial to mesenchymal tr...
Federica M Marelli-Berg,Dunja Aksentijevic
Federica M Marelli-Berg
Inflammatory processes underlie many diseases associated with injury of the heart muscle, including conditions without an obvious inflammatory pathogenic component such as hypertensive and diabetic cardiomyopathy. Persistence of cardiac inf...
Stress and catecholamines modulate the bone marrow microenvironment to promote tumorigenesis [0.03%]
应激和儿茶酚胺通过调节骨髓微环境促进肿瘤发生发展
Pauline Hanns,Anna M Paczulla,Michael Medinger et al.
Pauline Hanns et al.
High vascularization and locally secreted factors make the bone marrow (BM) microenvironment particularly hospitable for tumor cells and bones to a preferred metastatic site for disseminated cancer cells of different origins. Cancer cell ho...
Impact of prophylactic TNF blockade in the dual PD-1 and CTLA-4 immunotherapy efficacy and toxicity [0.03%]
预防性TNF阻滞剂对双重PD-1和CTLA-4免疫治疗的疗效和毒性的影响
Maite Alvarez,Itziar Otano,Luna Minute et al.
Maite Alvarez et al.
The TNF blockade therapy is currently a well-established treatment option for a variety of autoimmune diseases such as rheumatoid arthritis (RA), psoriasis or Crohn's disease, given the proinflammatory role of TNF in the course of these dis...