Frank Madeo,Nektarios Tavernarakis,José M Bravo-San Pedro et al.
Frank Madeo et al.
Niranjan Venkateswaran,Maralice Conacci-Sorrell
Niranjan Venkateswaran
Tryptophan is one of the eight essential amino acids that must be obtained from the diet. Interestingly, tryptophan is the least abundant amino acid in most proteins, a large portion of cellular tryptophan is converted into metabolites of t...
Fatty acids - from energy substrates to key regulators of cell survival, proliferation and effector function [0.03%]
脂肪酸-从能量底物到细胞存活、增殖和效应功能的关键调节因子
Danilo Cucchi,Dolores Camacho-Muñoz,Michelangelo Certo et al.
Danilo Cucchi et al.
Recent advances in immunology and cancer research show that fatty acids, their metabolism and their sensing have a crucial role in the biology of many different cell types. Indeed, they are able to affect cellular behaviour with great impli...
Zheng-Gang Liu,Delong Jiao
Zheng-Gang Liu
Necroptosis, known as programmed necrosis, is a form of caspase-independent, finely regulated cell death with necrotic morphology. Tumor necrosis, foci of necrotic cell death, occurs in advanced solid tumors and is often associated with poo...
Haiyan An,Tatyana A Shelkovnikova
Haiyan An
Eukaryotic cells contain several types of RNA-protein membraneless macro-complexes - ribonucleoprotein (RNP) granules that form by liquid-liquid phase separation. These structures represent biochemical microreactors for a variety of cellula...
Sandrine Passemard,Franck Perez,Pierre Gressens et al.
Sandrine Passemard et al.
Microcephaly is a neurodevelopmental condition characterized by a small brain size associated with intellectual deficiency in most cases and is one of the most frequent clinical sign encountered in neurodevelopmental disorders. It can resul...
Jin-Tao Li,Yi-Ping Wang,Miao Yin et al.
Jin-Tao Li et al.
Pancreatic ductal adenocarcinoma (PDAC) is predicted to become the second leading cause of death of patients with malignant cancers by 2030. Current options of PDAC treatment are limited and the five-year survival rate is less than 8%, lead...
LTX-315 sequentially promotes lymphocyte-independent and lymphocyte-dependent antitumor effects [0.03%]
LTX-315依次促进淋巴细胞非依赖性和淋巴细胞依赖性抗肿瘤作用
Hsin-Wei Liao,Christopher Garris,Christina Pfirschke et al.
Hsin-Wei Liao et al.
LTX-315 is an oncolytic peptide that has antitumor efficacy in mice grafted with various tumor cell lines and is currently being tested in phase II clinical trials. Here we aimed to further evaluate LTX-315 in conditional genetic mouse mode...
The impact of endothelial cell death in the brain and its role after stroke: A systematic review [0.03%]
脑内血管细胞死亡在卒中后的影响及其作用：系统综述
Marietta Zille,Maulana Ikhsan,Yun Jiang et al.
Marietta Zille et al.
The supply of oxygen and nutrients to the brain is vital for its function and requires a complex vascular network that, when disturbed, results in profound neurological dysfunction. As part of the pathology in stroke, endothelial cells die....
LTX-315 - a promising novel antitumor peptide and immunotherapeutic agent [0.03%]
LTX-315——一种有前景的抗肿瘤肽和免疫治疗剂
Dagmar Zweytick
Dagmar Zweytick