Towards understanding the role of Receptor Expression Enhancing Protein 5 (REEP5) in cardiac muscle and beyond [0.03%]
探究受体表达增强蛋白5（REEP5）在心肌及其他组织中的作用机制
Shin-Haw Lee,Sina Hadipour-Lakmehsari,Anthony O Gramolini
Shin-Haw Lee
The sarco-endoplasmic reticulum (SR/ER) is the largest membrane-bound organelle in eukaryotic cells and plays important roles in essential cellular processes, and in development and progression of many cardiac diseases. However, many aspect...
Mitochondria, mitophagy, and metabolic disease: towards assembling the puzzle [0.03%]
线粒体、线粒体自噬与代谢性疾病：拼图中的若干片段
Zhiyong Chen,Marine Berquez,Alessandro Luciani
Zhiyong Chen
Dysregulation of the mitochondrial network in terminally differentiated cells contributes to a broad spectrum of disorders. Methylmalonic acidemia (MMA) is an autosomal recessive inborn error of intermediary metabolism caused by the deficie...
Mitochondria in cancer [0.03%]
癌症中的线粒体功能异常
Debora Grasso,Luca X Zampieri,Tânia Capelôa et al.
Debora Grasso et al.
The rediscovery and reinterpretation of the Warburg effect in the year 2000 occulted for almost a decade the key functions exerted by mitochondria in cancer cells. Until recent times, the scientific community indeed focused on constitutive ...
Beatriz Villarejo-Zori,Juan Ignacio Jiménez-Loygorri,Patricia Boya
Beatriz Villarejo-Zori
HIF1α-dependent mitophagy facilitates cardiomyoblast differentiation [0.03%]
缺氧诱导因子HIF1α依赖性线粒体自噬促进心肌细胞分化
Jin-Feng Zhao,Catherine E Rodger,George F G Allen et al.
Jin-Feng Zhao et al.
Mitophagy is thought to play a key role in eliminating damaged mitochondria, with diseases such as cancer and neurodegeneration exhibiting defects in this process. Mitophagy is also involved in cell differentiation and maturation, potential...
Hans Zischka,Guido Kroemer
Hans Zischka
Toxic copper accumulation causes Wilson disease, but trace amounts of copper are required for cellular and organismal survival. In a recent paper Tsang et al. (Nat Cell Biol, doi: 10.1038/s41556-020-0481-4) demonstrate that copper binds wit...
Role of RNA Binding Proteins with prion-like domains in muscle and neuromuscular diseases [0.03%]
具有朊病毒样结构域的RNA结合蛋白在肌肉和神经肌肉疾病中的作用
Gina Picchiarelli,Luc Dupuis
Gina Picchiarelli
A number of neuromuscular and muscular diseases, including amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA) and several myopathies, are associated to mutations in related RNA-binding proteins (RBPs), including TDP-43, FUS,...
Coronavirus infections: Epidemiological, clinical and immunological features and hypotheses [0.03%]
冠状病毒感染：流行病学、临床和免疫学特征及假说
Didier Raoult,Alimuddin Zumla,Franco Locatelli et al.
Didier Raoult et al.
Coronaviruses (CoVs) are a large family of enveloped, positive-strand RNA viruses. Four human CoVs (HCoVs), the non-severe acute respiratory syndrome (SARS)-like HCoVs (namely HCoV 229E, NL63, OC43, and HKU1), are globally endemic and accou...
Xiaoshan Wu,Songlin Wang
Xiaoshan Wu
Cyclical renewal of integumentary organs, including hair, feathers, and teeth occurs throughout an organism's lifetime. Transition from the resting to the initiation stage is critical for each cycle, but the mechanism remains largely unknow...
RPA and Pif1 cooperate to remove G-rich structures at both leading and lagging strand [0.03%]
RPA和Pif1协同作用去除前导链和后随链上的G-富集结构
Laetitia Maestroni,Julien Audry,Pierre Luciano et al.
Laetitia Maestroni et al.
In Saccharomyces cerevisiae, the absence of Pif1 helicase induces the instability of G4-containing CEB1 minisatellite during leading strand but not lagging strand replication. We report that RPA and Pif1 cooperate to maintain CEB1 stability...