Mitochondria in cancer [0.03%]
癌症中的线粒体功能异常
Debora Grasso,Luca X Zampieri,Tânia Capelôa et al.
Debora Grasso et al.
The rediscovery and reinterpretation of the Warburg effect in the year 2000 occulted for almost a decade the key functions exerted by mitochondria in cancer cells. Until recent times, the scientific community indeed focused on constitutive ...
Beatriz Villarejo-Zori,Juan Ignacio Jiménez-Loygorri,Patricia Boya
Beatriz Villarejo-Zori
HIF1α-dependent mitophagy facilitates cardiomyoblast differentiation [0.03%]
缺氧诱导因子HIF1α依赖性线粒体自噬促进心肌细胞分化
Jin-Feng Zhao,Catherine E Rodger,George F G Allen et al.
Jin-Feng Zhao et al.
Mitophagy is thought to play a key role in eliminating damaged mitochondria, with diseases such as cancer and neurodegeneration exhibiting defects in this process. Mitophagy is also involved in cell differentiation and maturation, potential...
Hans Zischka,Guido Kroemer
Hans Zischka
Toxic copper accumulation causes Wilson disease, but trace amounts of copper are required for cellular and organismal survival. In a recent paper Tsang et al. (Nat Cell Biol, doi: 10.1038/s41556-020-0481-4) demonstrate that copper binds wit...
Role of RNA Binding Proteins with prion-like domains in muscle and neuromuscular diseases [0.03%]
具有朊病毒样结构域的RNA结合蛋白在肌肉和神经肌肉疾病中的作用
Gina Picchiarelli,Luc Dupuis
Gina Picchiarelli
A number of neuromuscular and muscular diseases, including amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA) and several myopathies, are associated to mutations in related RNA-binding proteins (RBPs), including TDP-43, FUS,...
Coronavirus infections: Epidemiological, clinical and immunological features and hypotheses [0.03%]
冠状病毒感染：流行病学、临床和免疫学特征及假说
Didier Raoult,Alimuddin Zumla,Franco Locatelli et al.
Didier Raoult et al.
Coronaviruses (CoVs) are a large family of enveloped, positive-strand RNA viruses. Four human CoVs (HCoVs), the non-severe acute respiratory syndrome (SARS)-like HCoVs (namely HCoV 229E, NL63, OC43, and HKU1), are globally endemic and accou...
Xiaoshan Wu,Songlin Wang
Xiaoshan Wu
Cyclical renewal of integumentary organs, including hair, feathers, and teeth occurs throughout an organism's lifetime. Transition from the resting to the initiation stage is critical for each cycle, but the mechanism remains largely unknow...
RPA and Pif1 cooperate to remove G-rich structures at both leading and lagging strand [0.03%]
RPA和Pif1协同作用去除前导链和后随链上的G-富集结构
Laetitia Maestroni,Julien Audry,Pierre Luciano et al.
Laetitia Maestroni et al.
In Saccharomyces cerevisiae, the absence of Pif1 helicase induces the instability of G4-containing CEB1 minisatellite during leading strand but not lagging strand replication. We report that RPA and Pif1 cooperate to maintain CEB1 stability...
Biomechanical stress provides a second hit in the establishment of BMP/TGFβ-related vascular disorders [0.03%]
生物力学应力在BMP/TGFβ相关血管疾病发病机制中的作用
Christian Hiepen,Jerome Jatzlau,Petra Knaus
Christian Hiepen
Cardiovascular disorders are still the leading cause for mortality in the western world and challenge economies with steadily increasing healthcare costs. Understanding the precise molecular pathomechanisms behind and identifying players in...
Fine intercellular connections in development: TNTs, cytonemes, or intercellular bridges? [0.03%]
发育中的细胞间精细连接：TNTs、细胞膜伪足或细胞间桥梁？
Olga Korenkova,Anna Pepe,Chiara Zurzolo
Olga Korenkova
Intercellular communication is a fundamental property of multicellular organisms, necessary for their adequate responses to changing environment. Tunneling nanotubes (TNTs) represent a novel means of intercellular communication being a long...