The IRE1 [Formula: see text] -XBP1s-NF [Formula: see text] B axis controls cell survival and epithelial differentiation under osmotic stress through arachidonic acid metabolism activation [0.03%]
IRE1 [Formula: see text] -XBP1s-NF [Formula: see text] B轴通过活化花生四烯酸代谢控制渗透压应激下的细胞存活和上皮分化
Leandro Gastón Parra,Cecilia Irene Casali,Dylan Ezequiel Sendyk et al.
Leandro Gastón Parra et al.
Arachidonic acid (AA) metabolism plays a critical role in renal cell osmoadaptation. We recently demonstrated that hypertonicity induces the expression and activation of cytosolic phospholipase A 2 (cPLA 2 ). On one hand, AA released ...
Multifaceted role of CNPY2 beyond ER stress: Disease implications and therapeutic potential [0.03%]
CNPY2在内质网应激之外的多面手角色：疾病影响和治疗潜力
Shima Ebadollahibaruq,Lingbin Meng,Feng Hong
Shima Ebadollahibaruq
Canopy homolog protein 2 (CNPY2), an endoplasmic reticulum (ER) luminal protein exhibits broad tissue distribution and regulates cellular homeostasis, including unfolded protein responses (UPR), mitochondrial dynamics, oxidative stress, and...
Antifungal peptides: From modes of action to synergistic and immunologic potential [0.03%]
抗真菌肽：从作用机制到协同和免疫潜能
Didac Carmona-Gutierrez,Maria A Bauer,Katharina Kainz et al.
Didac Carmona-Gutierrez et al.
Fungal infections pose a significant global health threat with rising morbidity and mortality rates. However, the repertoire of effective antifungal drugs remains narrow, a challenge that is further exacerbated by the increasing emergence o...
Reversal of Cushing syndrome by antibody-mediated neutralization of ACBP/DBI [0.03%]
通过抗体介导的ACBP / DBI中和逆转库欣综合征
Zhe Shen,Hui Pan,Xiaolian Deng et al.
Zhe Shen et al.
Cushing syndrome (CS) is caused by an increase in endogenous or exogenous glucocorticoids, leading to major alterations in body composition, including visceral obesity, sarcopenia, osteoporosis, type 2 diabetes, and dyslipidemia. Cardiovasc...
Quantifying replication stress in cancer without proliferation confounding [0.03%]
无需增殖干扰地量化癌症中的复制压力
Philipp Jungk,Maik Kschischo
Philipp Jungk
Replication stress (RS) is a major driver of genomic instability and cancer development through impaired DNA replication that can lead to chromosomal instability (CIN). Although RS is mechanistically linked to CIN, its relationship with cel...
Brittney Adams,Stanislaw Walkowiak,Mohammed K Hankir
Brittney Adams
Removing certain essential amino acids from the diet is known to promote weight loss in rodents via effects on food intake and energy expenditure. Two complementary articles by Varghese et al [Nature 643(8072)] and Lee et al [Nature Metabol...
Xiaohan Chen,Jiaxu Hong,Qihua Le
Xiaohan Chen
The dysfunction of mitochondria, the "energy factories" of cells, not only causes an insufficiency of energy production but also leads to various pathological alterations in cells such as the accumulation of reactive oxygen species, inflamm...
Oxidative stress induces cortical stiffening and cytoskeletal remodelling in pre-apoptotic cancer cells [0.03%]
氧化应激诱导癌细胞凋亡前皮质硬化和细胞骨架重塑
Aiman Jalmukhambetova,Aidana Baltabekova,Aizhan Tolebay et al.
Aiman Jalmukhambetova et al.
An imbalanced production of reactive oxygen species (ROS) is linked to various aspects of cancer development, including cytoskeletal remodelling. However, the relationship between ROS, actin and cellular stiffness remains controversial. Her...
Datopotamab deruxtecan induces hallmarks of immunogenic cell death [0.03%]
Datopotamab_deruxtecan诱导免疫原性细胞死亡标志物出现
Sabrina Forveille,Marion Leduc,Allan Sauvat et al.
Sabrina Forveille et al.
Antibody-drug conjugates (ADCs) offer a strategy for targeted delivery of cytotoxic agents to cancer cells. In this study, we investigated the mechanism of action of datopotamab deruxtecan, an ADC composed of a monoclonal antibody targeting...
Vera Schmiedhofer,Julian Sommersguter-Wagner,Oskar Knittelfelder et al.
Vera Schmiedhofer et al.
High carbohydrate intake, a characteristic of many Western diets, is a major contributor to age-associated pathologies. Here, we explored the molecular consequences of sugar overload during chronological aging in the yeast Saccharomyces cer...