Adversity, adiposity, nutrition and metabolic well-being in multi-ethnic Asia [0.03%]
多民族亚洲的逆境、肥胖、营养和代谢健康
Theresia H Mina,Pritesh R Jain,Nita G Forouhi et al.
Theresia H Mina et al.
Obesity, diabetes and cardiovascular disease are rising rapidly in Asia. Population-based data consistently show that Asians are at higher risk for these non-communicable diseases than their European counterparts, especially when living in ...
Lamin A/C-regulated cysteine catabolic flux modulates stem cell fate through epigenome reprogramming [0.03%]
泛素化修饰介导的胱氨酸分解代谢重编程通过重塑表观遗传调控干细胞分化命运
Yinuo Wang,Haojie Shi,Janina Wittig et al.
Yinuo Wang et al.
Spatiotemporal changes in the nuclear lamina and cell metabolism shape cell fate, yet their interplay is poorly understood. Here we identify lamin A/C as a key regulator of cysteine catabolic flux essential for proper cell fate and longevit...
Dan Huang,Ziwei Dai
Dan Huang
Author Correction: m6A modification-tuned sphingolipid metabolism regulates postnatal liver development in male mice [0.03%]
作者更正：m6A甲基化调节的鞘脂代谢调控雄性小鼠产后肝发育
Shiguan Wang,Shanze Chen,Jianfeng Sun et al.
Shiguan Wang et al.
Published Erratum
Nature metabolism. 2026 Jan 27. DOI:10.1038/s42255-026-01468-1 2026
Unravelling the molecular mechanisms causal to type 2 diabetes across global populations and disease-relevant tissues [0.03%]
在全球人群中解锁与2型糖尿病相关的分子机制及疾病相关组织的作用
Ozvan Bocher,Ana Luiza Arruda,Satoshi Yoshiji et al.
Ozvan Bocher et al.
Type 2 diabetes (T2D) is a prevalent disease arising from complex molecular mechanisms. Here we leverage T2D genetic associations to identify causal molecular mechanisms in an ancestry-aware and tissue-aware manner. Using two-sample Mendeli...
IL-21 mediates crosstalk between T cells and NK cells during the remission of type 1 diabetes [0.03%]
一种新的免疫调节机制：T细胞通过分泌IL-21促进NK细胞的发育及功能以治疗I型糖尿病
Kang Lei,Xinyu Li,Ting Zhong et al.
Kang Lei et al.
The innate immune system is increasingly recognized as a contributor to the development of type 1 diabetes (T1D), but the role of natural killer (NK) cells remains largely unclear. Here, we identify an expanded subset of transcriptionally a...
Distinct sympathetic projections to brown fat regulate thermogenesis and glucose tolerance [0.03%]
不同的交感神经投射调节褐色脂肪的产热和葡萄糖耐量
Daniele Neri,Seoeun Lee,Alexis M Fohn et al.
Daniele Neri et al.
Brown adipose tissue (BAT) contributes to thermoregulation and glucose metabolism, but how these functions are coordinated remains unclear. While thermogenesis in the activated BAT typically coincides with increased blood flow and glucose u...
Xun Huang,Li Ye
Xun Huang
Chronic stress drives liver cancer by impairing the hepatic kynurenine pathway and immune surveillance [0.03%]
慢性压力通过损害肝脏犬尿氨酸途径和免疫监视而诱发肝癌
Renhui Sun,Deyan Jiao,Wenjing Yuan et al.
Renhui Sun et al.
Psychological stress is increasingly linked to liver disease, but the underlying mechanisms remain unclear. Here we show that chronic stress disrupts a brain-liver circuit that impairs hepatic CD8+ T cell immunity and accelerates liver canc...