Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice [0.03%]
Milan R Savani,Bingbing Li,Bailey C Smith et al.
Milan R Savani et al.
Stable isotope-tracing assays track few metabolites, yet cells use many nutrients to sustain nitrogen metabolism. Here we create a platform for tracing 30 nitrogen isotope-labelled metabolites in parallel to enable a system-level understand...
Andrew J Scott,Costas A Lyssiotis,Daniel R Wahl
Andrew J Scott
Good things come in twos [0.03%]
FXR-YAP signalling maintains biliary epithelial cell identity and preserves liver homeostasis [0.03%]
Paula Sánchez-Sánchez,Zhaoshuo Wang,Sladjana Zagorac et al.
Paula Sánchez-Sánchez et al.
Bile acids (BAs) flow through ducts lined by biliary epithelial cells (BECs), which preserve ductal integrity and liver homeostasis. Failure of this barrier causes BA accumulation in the liver parenchyma, and ultimately fibrosis. Here we sh...
FXR's double life in bile ducts [0.03%]
Shogo Takahashi,Frank J Gonzalez
Shogo Takahashi
Timothy Budden,Noah Palombo,Shilpa Gurung et al.
Timothy Budden et al.
Squamous cell carcinomas (SCCs) originate in epithelial tissues of older individuals who have been exposed to environmental carcinogens. Despite overlapping clinical hallmarks, SCCs from different anatomic sites have different prognoses. He...
Gul Muneer,Sara Zanivan
Gul Muneer
Elisabetta Manduchi,Hélène C Descamps,Jinping Liu et al.
Elisabetta Manduchi et al.
Although the prevalence of type 2 diabetes (T2D) increases with age, most adults maintain normoglycaemia despite rising insulin resistance owing to the adaptive capacity of pancreatic beta cells to meet increased metabolic demand. However, ...
Cell-specific DNA methylation in human alpha and beta cells regulates gene expression in type 2 diabetes [0.03%]
Jones K Ofori,Sabrina Ruhrmann,Axel Lindström et al.
Jones K Ofori et al.
Epigenome-wide studies of pancreatic islets provide valuable insights into type 2 diabetes (T2D) but lack methylomes from individual cell types. Here we show changes to alpha and beta cell-specific methylomes and transcriptomes from people ...
Emily Hodges,Guoqiang Gu
Emily Hodges