Lipid-dependent accrual of a subset of monocyte-derived macrophages is essential for tissue regeneration [0.03%]
脂质依赖的单核细胞衍生巨噬细胞亚群的积累在组织再生中必不可少
Tao Yao,Xin Tian,Linbin Rao et al.
Tao Yao et al.
Tissue regeneration is essential for maintaining tissue homoeostasis and influences disease progression. In the liver, injury evokes a complex regenerative response with robust immune activation and metabolic rewiring, yet how these process...
Ashwin Woodhoo,Marta Varela-Rey
Ashwin Woodhoo
Metabolic regulation by tanycyte-derived extracellular vesicles through insulin precursor-mediated neuronal recognition and mTORC component delivery [0.03%]
下丘脑胶质细胞源外泌体通过胰岛素前体蛋白介导的神经元识别及mTORC组分传递调控代谢
Yuna Choi,Min Woo Kim,Gyeongyun Go et al.
Yuna Choi et al.
The hypothalamus regulates feeding and metabolic balance in response to metabolic cues. Here we report that extracellular vesicles (EVs) are secreted from the mediobasal hypothalamus in a diurnal manner that is influenced by daily feeding. ...
Khadija Khan,Clair Crewe
Khadija Khan
Extracellular CD44 lactylation impairs CD8+ T cell function in KRAS-mutant colorectal cancer [0.03%]
细胞外CD44半乳糖化会损害KRAS突变结直肠癌的CD8+T细胞功能
Yun Yang,Yong Wu,Xin Guo et al.
Yun Yang et al.
Nannan Xu,Xuemei Tong
Nannan Xu
Early-activated extracellular matrix proteins shape the metabolic and spatial dynamics of the kidney fibrotic microenvironment [0.03%]
早期活化的胞外基质蛋白重塑肾脏纤维化微环境的代谢和空间动力学
Yuan Gui,Wenxue Li,Jia-Jun Liu et al.
Yuan Gui et al.
The fibrotic kidney microenvironment is shaped by cellular crosstalk, extracellular matrix (ECM) remodelling, metabolic reprogramming and spatial heterogeneity. While late-stage ECM changes dominate fibrosis, the role of early-activated mat...
Bandy Chen,Amanda Rodríguez-Díaz,Marc Schneeberger et al.
Bandy Chen et al.
The parallel rise in obesity and neurological disorders suggests a potential mechanistic link between these two conditions. Midlife obesity is a well-established risk factor for cognitive decline and neurological disorders; however, the und...