Proximity-induced caspase-9 activation on a DNA origami-based synthetic apoptosome [0.03%]
基于DNA折纸技术的合成凋亡小体诱导caspase-9激活
Bas J H M Rosier,Albert J Markvoort,Berta Gumí Audenis et al.
Bas J H M Rosier et al.
Living cells regulate key cellular processes by spatial organisation of catalytically active proteins in higher-order signalling complexes. These act as organising centres to facilitate proximity-induced activation and inhibition of multipl...
Probing the Transition State in Enzyme Catalysis by High-Pressure NMR Dynamics [0.03%]
利用高压核磁共振研究酶催化反应的过渡态
John B Stiller,S Jordan Kerns,Marc Hoemberger et al.
John B Stiller et al.
Protein conformational changes are frequently essential for enzyme catalysis, and in several cases, shown to be the limiting factor for overall catalytic speed. However, a structural understanding of corresponding transition states, needed ...
Supported Catalyst Deactivation by Decomposition into Single Atoms Is Suppressed by Increasing Metal Loading [0.03%]
通过增加金属含量抑制催化剂分解为单原子从而抑制催化剂失活
Emmett D Goodman,Aaron C Johnston-Peck,Elisabeth M Dietze et al.
Emmett D Goodman et al.
In the high-temperature environments needed to perform catalytic processes, supported precious metal catalysts severely lose their activity over time. Even brief exposure to high temperatures can lead to significant losses in activity, whic...
Deciphering the enzymatic mechanism of sugar ring contraction in UDP-apiose biosynthesis [0.03%]
揭示UDP-apiosphate生物合成中糖环收缩的酶促机制
Simone Savino,Annika J E Borg,Alexander Dennig et al.
Simone Savino et al.
D-Apiose is a C-branched pentose sugar important for plant cell wall development. Its biosynthesis as UDP-D-apiose involves decarboxylation of the UDP-D-glucuronic acid precursor coupled to pyranosyl-to-furanosyl sugar ring contraction. Thi...
Direct catalytic transformation of white phosphorus into arylphosphines and phosphonium salts [0.03%]
白磷直接催化转化为芳基膦和
Ulrich Lennert,Percia Beatrice Arockiam,Verena Streitferdt et al.
Ulrich Lennert et al.
Phosphorus compounds are ubiquitous in the chemical sciences, finding applications throughout industry and academia. Of particular interest to synthetic chemists are organophosphorus compounds, which contain P-C bonds. However, state-of-the...
Non-proteinaceous hydrolase comprised of a phenylalanine metallo-supramolecular amyloid-like structure [0.03%]
由苯丙氨酸金属超分子淀粉样类结构组成的非蛋白质水解酶
Pandeeswar Makam,Sharma S R K C Yamijala,Kai Tao et al.
Pandeeswar Makam et al.
Enzymatic activity is crucial for various technological applications, yet the complex structures and limited stability of enzymes often hinder their use. Hence, de novo design of robust biocatalysts that are much simpler than their natural ...
Regiodivergent enantioselective C-H functionalization of Boc-1,3-oxazinanes and application to the synthesis of β2 and β3-amino acids [0.03%]
Boc-1,3-氧氮烷的区域和对映选择性C-H官能团化及在β2和β3氨基酸合成中的应用
Weilong Lin,Ke-Feng Zhang,Olivier Baudoin
Weilong Lin
β2- and β3-Amino acids are important chiral building blocks for the design of new pharmaceuticals and peptidomimetics. Here we report a straightforward regio- and enantiodivergent access to these compounds using a one-pot reaction compose...
Cancer-derived exosomes loaded with ultrathin palladium nanosheets for targeted bioorthogonal catalysis [0.03%]
负载超薄钯纳米片的癌症衍生外泌体用于靶向生物正交催化
María Sancho-Albero,Belén Rubio-Ruiz,Ana M Pérez-López et al.
María Sancho-Albero et al.
The transformational impact of bioorthogonal chemistries has inspired new strategies for the in vivo synthesis of bioactive agents through non-natural means. Among these, palladium (Pd) catalysts have played a prominent role in the growing ...
Catalytic hydrogen atom transfer from hydrosilanes to vinylarenes for hydrosilylation and polymerization [0.03%]
硅烷的催化加氢硅烷化和聚合反应
Parham Asgari,Yuanda Hua,Apparao Bokka et al.
Parham Asgari et al.
Because of the importance of hydrogen atom transfer (HAT) in biology and chemistry, there is increased interest in new strategies to perform HAT in a sustainable manner. Here, we describe a sustainable, net redox-neutral HAT process involvi...
Ethylene Glycol as an Efficient and Reversible Liquid Organic Hydrogen Carrier [0.03%]
乙二醇作为一种高效且可逆的液态有机储氢载体
You-Quan Zou,Niklas von Wolff,Aviel Anaby et al.
You-Quan Zou et al.
Hydrogen has long been regarded as an ideal alternative clean energy vector to overcome the drawbacks of fossil technology. However, the direct utilization of hydrogen is challenging, due to low volumetric energy density of hydrogen gas and...