Reversible H2 Oxidation and Evolution by Hydrogenase Embedded in a Redox Polymer Film [0.03%]
嵌入在导电聚合物膜中的氢酶可逆地催化析氢和氧化反应
Steffen Hardt,Stefanie Stapf,Dawit T Filmon et al.
Steffen Hardt et al.
Efficient electrocatalytic energy conversion requires the devices to function reversibly, i.e. deliver a significant current at minimal overpotential. Redox-active films can effectively embed and stabilise molecular electrocatalysts, but me...
19F- and 18F-Arene Deoxyfluorination via Organic Photoredox-Catalysed Polarity-Reversed Nucleophilic Aromatic Substitution [0.03%]
通过有机光氧化还原催化反向亲核芳香取代实现芳环的19F和18F烷氧基氟化反应
Nicholas E S Tay,Wei Chen,Alison Levens et al.
Nicholas E S Tay et al.
Nucleophilic aromatic substitution (SNAr) is routinely used to install 19F- and 18F- in aromatic molecules, but is typically limited to electron-deficient arenes due to kinetic barriers associated with C-F bond formation. Here we demonstrat...
Practical Synthesis of C-1 Deuterated Aldehydes Enabled by NHC Catalysis [0.03%]
N-杂环卡宾催化C-1位氘代醛的合成方法学研究
Huihui Geng,Xiaobei Chen,Jingjing Gui et al.
Huihui Geng et al.
The recent surge in applications of deuterated pharmaceutical agents has created an urgent demand for synthetic methods that efficiently generate deuterated building blocks. Here we show that N-heterocyclic carbenes (NHC) promote a reversib...
RetroBioCat as a computer-aided synthesis planning tool for biocatalytic reactions and cascades [0.03%]
用于生物催化反应和级联的计算机辅助合成规划工具RetroBioCat
William Finnigan,Lorna J Hepworth,Sabine L Flitsch et al.
William Finnigan et al.
As the enzyme toolbox for biocatalysis has expanded, so has the potential for the construction of powerful enzymatic cascades for efficient and selective synthesis of target molecules. Additionally, recent advances in computer-aided synthes...
Elucidating structure-performance relationships in whole-cell cooperative enzyme catalysis [0.03%]
全细胞协同酶催化的结构性能关系研究
Mason R Smith,Hui Gao,Ponnandy Prabhu et al.
Mason R Smith et al.
Cooperative enzyme catalysis in nature has long inspired the application of engineered multi-enzyme assemblies for industrial biocatalysis. Despite considerable interest, efforts to harness the activity of cell-surface displayed multi-enzym...
Fungal-derived brevianamide assembly by a stereoselective semipinacolase [0.03%]
由立体选择性半薄荷醛异构酶组装的真菌来源的brevianamide
Ying Ye,Lei Du,Xingwang Zhang et al.
Ying Ye et al.
Fungal bicyclo[2.2.2]diazaoctane indole alkaloids represent an important family of natural products with a wide-spectrum of biological activities. Although biomimetic total syntheses of representative compounds have been reported, the detai...
α-Branched amines by catalytic 1,1-addition of C-H bonds and aminating agents to terminal alkenes [0.03%]
通过末端烯烃和胺源的C-H键催化1,1-加成制备α-支化胺
Soham Maity,Tyler J Potter,Jonathan A Ellman
Soham Maity
α-Branched amines are present in hundreds of pharmaceutical agents and clinical candidates and are important targets for synthesis. Here we show the convergent synthesis of α-branched amines from three readily accessible starting material...
Cascade CuH-Catalysed Conversion of Alkynes to Enantioenriched 1,1-Disubstituted Products [0.03%]
铜催化炔烃反应合成光学活性1,1-二取代产物的研究
De-Wei Gao,Yang Gao,Huiling Shao et al.
De-Wei Gao et al.
Enantioenriched α-aminoboronic acids play a unique role in medicinal chemistry and have emerged as privileged pharmacophores in proteasome inhibitors. Additionally, they represent synthetically useful chiral building blocks in organic synt...
Copper-catalysed benzylic C-H coupling with alcohols via radical relay enabled by redox buffering [0.03%]
基于氧化还原缓冲的自由基接力活化铜催化醇与仲伯碳氢键交叉偶联反应
Huayou Hu,Si-Jie Chen,Mukunda Mandal et al.
Huayou Hu et al.
Cross-coupling reactions enable rapid, convergent synthesis of diverse molecules and provide the foundation for modern chemical synthesis. The most widely used methods employ sp2-hybridized coupling partners, such as aryl halides or related...
Nanostructuring unlocks high performance of platinum single-atom catalysts for stable vinyl chloride production [0.03%]
亚纳米结构解开了Pt单原子催化剂稳定氯乙烯生产的高性能解锁之谜
Selina K Kaiser,Edvin Fako,Gabriele Manzocchi et al.
Selina K Kaiser et al.
A worldwide replacement of the toxic mercuric chloride catalyst in vinyl chloride manufacture via acetylene hydrochlorination is slowed down by the limited durability of alternative catalytic systems at high space velocities. Here, we demon...