Biocatalytic, Enantioenriched Primary Amination of Tertiary C-H Bonds [0.03%]
三级C-H键的生物催化和对映 enrichment primary amination
Runze Mao,Shilong Gao,Zi-Yang Qin et al.
Runze Mao et al.
Intermolecular functionalization of tertiary C-H bonds to construct fully substituted stereogenic carbon centers represents a formidable challenge: without the assistance of directing groups, state-of-the-art catalysts struggle to introduce...
Nickel-catalysed enantioselective alkene dicarbofunctionalization enabled by photochemical aliphatic C-H bond activation [0.03%]
光化学活化烷基C-H键实现的手性镍催化烯烃双官能化反应
Xia Hu,Iván Cheng-Sánchez,Wangqing Kong et al.
Xia Hu et al.
The development of novel strategies to rapidly construct complex chiral molecules from readily available feedstocks is a long-term pursuit in the chemistry community. Radical-mediated alkene difunctionalizations represent an excellent platf...
Congested C(sp3)-rich architectures enabled by iron-catalysed conjunctive alkylation [0.03%]
铁催化联结型烷基化反应构建富碳(sp3)骨架化合物
Tong-De Tan,Juan M I Serviano,Xiaohua Luo et al.
Tong-De Tan et al.
Catalytic cross-coupling by transition metals has revolutionized the formation of C-C bonds in organic synthesis. However, the challenge of forming multiple alkyl-alkyl bonds in crowded environments remains largely unresolved. Here, we repo...
Epistasis arises from shifting the rate-limiting step during enzyme evolution of a β-lactamase [0.03%]
表型上相互作用的突变如何通过改变酶进化的速率限制步骤而产生(epistasis-arises-from-shifting-the-rate-limiting-step-during-enzyme-evolution-of-a-%CE%B2-lactamase)
Christopher Fröhlich,H Adrian Bunzel,Karol Buda et al.
Christopher Fröhlich et al.
Epistasis, the non-additive effect of mutations, can provide combinatorial improvements to enzyme activity that substantially exceed the gains from individual mutations. Yet the molecular mechanisms of epistasis remain elusive, undermining ...
A synthetic methylotrophic Escherichia coli as a chassis for bioproduction from methanol [0.03%]
一种合成型甲醇同化利用工程大肠杆菌底盘细胞用于甲醇生物制造
Michael A Reiter,Timothy Bradley,Lars A Büchel et al.
Michael A Reiter et al.
Methanol synthesized from captured greenhouse gases is an emerging renewable feedstock with great potential for bioproduction. Recent research has raised the prospect of methanol bioconversion to value-added products using synthetic methylo...
Stereoselective Construction of β-, γ-, and δ-Lactam Rings via Enzymatic C-H Amidation [0.03%]
基于酶催化的C-H氨化反应的立体选择性构建β-、γ-和δ-内酰胺环
Satyajit Roy,David A Vargas,Pengchen Ma et al.
Satyajit Roy et al.
Lactam rings are found in many biologically active natural products and pharmaceuticals, including important classes of antibiotics. Methods for the asymmetric synthesis of these molecules are therefore highly desirable, particularly throug...
Zhengyi Zhang,Jianqiang Feng,Chao Yang et al.
Zhengyi Zhang et al.
Since the discovery of Hofmann-Löffler-Freytag reaction more than 130 years ago, nitrogen-centered radicals have been widely studied in both structures and reactivities1-2. Nevertheless, catalytic enantioselective intermolecular radical hy...
Interfacial Tuning of Electrocatalytic Ag Surfaces for Fragment-Based Electrophile Coupling [0.03%]
用于碎片偶联电催化剂Ag表面的界面调控
Qiu-Cheng Chen,Sarah Kress,Rocco Molinelli et al.
Qiu-Cheng Chen et al.
Construction of C‒C bonds in medicinal chemistry frequently draws on the reductive coupling of organic halides with ketones or aldehydes. Catalytic C(sp3)‒C(sp3) bond formation, however, is constrained by the competitive side reactivity o...
In vitro construction of the COQ metabolon unveils the molecular determinants of coenzyme Q biosynthesis [0.03%]
体外构建COQ代谢物揭示辅酶Q生物合成的分子决定因素
Callum R Nicoll,Laura Alvigini,Andrea Gottinger et al.
Callum R Nicoll et al.
Metabolons are protein assemblies that perform a series of reactions in a metabolic pathway. However, the general importance and aptitude of metabolons for enzyme catalysis remain poorly understood. In animals, biosynthesis of coenzyme Q is...
Enzyme-controlled stereoselective radical cyclization to arenes enabled by metalloredox biocatalysis [0.03%]
金属酶氧化生物催化控制的自由基环化到芳香族化合物的立体选择性反应
Wenzhen Fu,Natalia M Neris,Yue Fu et al.
Wenzhen Fu et al.
The effective induction of high levels of stereocontrol for free radical-mediated transformations represents a notorious challenge in asymmetric catalysis. Herein, we describe a novel metalloredox biocatalysis strategy to repurpose natural ...