Dissecting the polygenic architecture of psychopathology via singular value decomposition of eight psychiatric genome-wide association studies and evaluation of component-based polygenic scores [0.03%]
基于八个性心理疾病全基因组关联研究的奇异值分解剖析精神疾病的多基因结构及成分基多基因评分评估
Fernando Facal,Ana M Pérez-Gutiérrez,Javier Costas
Fernando Facal
Background: Current research suggests that genetic risk for psychiatric disorders is largely due to distinct combinations of many common variants shared by different disorders. This points to the existence of latent compo...
Haifeng Zhang,Jialong Yi,Xin Yu
Haifeng Zhang
China launches its first diagnostic criteria for occupational post-traumatic stress disorder [0.03%]
我国首部职业创伤后应激障碍诊断标准出台
Bangshan Liu,Junzhe Cheng,Wei Jiang et al.
Bangshan Liu et al.
Olfactory enrichment mitigates delayed neurocognitive recovery after major orthopaedic surgery in older patients: A randomised controlled trial [0.03%]
嗅觉刺激可缓解老年患者大手术后的迟发性神经认知功能恢复障碍：一项随机对照试验
Xinchun Mei,Zihan Ni,Shiyu Zhong et al.
Xinchun Mei et al.
Background: Delayed neurocognitive recovery (dNCR) is a prevalent complication in older patients undergoing surgery. It may progress to long-term cognitive impairment and increase the risk of Alzheimer's disease. ...
Global burden, risk factors and projections of self-harm mortality in adults aged 65+ years: A 60-year trend analysis from the Global Burden of Disease Study 2021 [0.03%]
2021年全球疾病负担研究中65岁及以上老年人自杀身亡的全球疾病负担、危险因素及趋势分析（1960～2021年）
Jinjie Xu,Yiman Guo,Zizhao Feng et al.
Jinjie Xu et al.
Background: Epidemiological research on self-harm in older adults (aged 65+ years) remains scarce despite its growing public health significance amid global ageing. ...
Dynamic trajectories of neuropsychiatric symptoms predict Alzheimer's disease risk and clinical phenotypes [0.03%]
神经精神症状的动态轨迹预测阿尔茨海默病风险和临床表型
Wenzheng Liu,Yan Wang,Yuhang Shi et al.
Wenzheng Liu et al.
Background: Neuropsychiatric symptoms (NPS) may serve as early predictors of Alzheimer's disease (AD). However, NPS evolve over time, and most existing studies have relied on single or sparse assessments that do not captu...
Causal machine learning analysis identifies subpopulations most likely to benefit from healthy lifestyles for cognitive outcomes [0.03%]
因果机器学习分析确定了最有可能从健康生活方式中受益的认知结果亚群体
Youjin Jiang,Yi Ding,Qiuyu Cao et al.
Youjin Jiang et al.
Background: With dementia posing an escalating public health threat, adopting healthy lifestyles is increasingly recognised as a key preventive measure for preserving cognitive function. However, the effect of multidomain...
Shared genetic variants across substance use disorders implicate common neurobiological pathways, a genome-wide mixed methods study [0.03%]
横断面基因组学混合研究发现多种物质使用障碍共有的遗传变异，涉及常见的神经生物学通路
Børge Holen,Zillur Rahman,Alexey A Shadrin et al.
Børge Holen et al.
Background: Substance use disorders (SUDs) are highly heritable, but the extent of shared and distinct genetic architecture across different SUDs is unclear. ...
Sevoflurane versus propofol and the long-term risk of attention-deficit/hyperactivity disorder in children [0.03%]
异丙酚与七氟醚与儿童注意缺陷多动障碍长期发病风险的关系研究
Mingyang Sun,Yangyang Wang,Yuqin Tang et al.
Mingyang Sun et al.
Background: Preclinical studies have shown that volatile anaesthetics, particularly sevoflurane, can disrupt neurodevelopment by inducing neuronal apoptosis, neuroinflammation and altered synaptic plasticity during critic...