Linda Alex,Nikolaos G Frangogiannis
Linda Alex
The adult mammalian heart lacks regenerative capacity and heals through activation of an inflammatory cascade that leads to the formation of a collagen-based scar. Although scar formation is important to preserve the structural integrity of...
Jaana Schneider,Marianne Pultar,Wolfgang Holnthoner
Jaana Schneider
Upon implantation, engineered tissues rely on the supply with oxygen and nutrients as well as the drainage of interstitial fluid. This prerequisite still represents one of the current challenges in the engineering and regeneration of tissue...
Ebba Brakenhielm,Vincent Richard
Ebba Brakenhielm
Despite tremendous efforts in preclinical research over the last decades, the clinical translation of therapeutic angiogenesis to grow stable and functional blood vessels in patients with ischemic diseases continues to prove challenging. In...
Tatiane Gorski,Katrien De Bock
Tatiane Gorski
Skeletal muscle relies on an ingenious network of blood vessels, which ensures optimal oxygen and nutrient supply. An increase in muscle vascularization is an early adaptive event to exercise training, but the cellular and molecular mechani...
Paolo Madeddu
Paolo Madeddu
Improved endothelialization of small-diameter ePTFE vascular grafts through growth factor therapy [0.03%]
通过生长因子治疗改善小直径ePTFE血管移植物的内皮化
Jarkko P Hytönen,Olli Leppänen,Jouni Taavitsainen et al.
Jarkko P Hytönen et al.
Background: Prosthetic vascular grafts in humans characteristically lack confluent endothelialization regardless of the duration of implantation. Use of high-porosity grafts has been proposed as a way to induce endothelia...
Nektarios Barabutis
Nektarios Barabutis
Endothelial barrier dysfunction is the hallmark of inflammatory lung disease, including Acute Lung Injury and Acute Respiratory Distress Syndrome. The purpose of the present editorial is to emphasize on recent advances in the corresponding ...
Targeting epigenetic mechanisms as an emerging therapeutic strategy in pulmonary hypertension disease [0.03%]
表观遗传机制在肺动脉高压治疗中的应用展望
Malik Bisserier,Radoslav Janostiak,Frank Lezoualc&#x;h et al.
Malik Bisserier et al.
Pulmonary arterial hypertension (PAH) is a multifactorial cardiopulmonary disease characterized by an elevation of pulmonary artery pressure (PAP) and pulmonary vascular resistance (PVR), which can lead to right ventricular (RV) failure, mu...