James T Pearson,Mikiyasu Shirai,Vijayakumar Sukumaran et al.
James T Pearson et al.
Ghrelin is a small peptide with important roles in the regulation of appetite, gut motility, glucose homeostasis as well as cardiovascular protection. This review highlights the role that acyl ghrelin plays in maintaining normal endothelial...
HMGB1-mediated apoptosis and autophagy in ischemic heart diseases [0.03%]
高迁移率族蛋白box1在缺血性心脏病所介导的细胞凋亡和自噬中的作用
Eleonora Foglio,Laura Pellegrini,Antonia Germani et al.
Eleonora Foglio et al.
Acute myocardial infarction (MI) and its consequences are the most common and lethal heart syndromes worldwide and represent a significant health problem. Following MI, apoptosis has been generally seen as the major contributor of the cardi...
Carlo Dal Lin,Francesco Tona,Elena Osto
Carlo Dal Lin
The heart and the immune system are highly integrated systems cross-talking through cytokines, hormones and neurotransmitters. Their balance can be altered by numerous physical or psychological stressors leading to the onset of inflammation...
MicroRNAs orchestrating senescence of endothelial and vascular smooth muscle cells [0.03%]
microRNA调控血管内皮细胞和血管平滑肌细胞的衰老过程
Ornella Colpani,Gaia Spinetti
Ornella Colpani
During organism aging, the process of cellular senescence is triggered by critical stressors such as DNA damage, oncogenes, oxidative stress, and telomere erosion, and vascular cells are not exempted. Senescent cells stop proliferating but ...
Plasticity of vascular resident mesenchymal stromal cells during vascular remodeling [0.03%]
血管重建过程中血管驻留间质干细胞的可塑性
Xuechong Hong,Wenduo Gu
Xuechong Hong
Vascular remodeling is a complex and dynamic pathological process engaging many different cell types that reside within the vasculature. Mesenchymal stromal/stem cells (MSCs) refer to a heterogeneous cell population with the plasticity to d...
Stephen P Gray,Ajay M Shah,Ioannis Smyrnias
Stephen P Gray
The heart relies on complex mechanisms that provide adequate myocardial oxygen supply in order to maintain its contractile function. At the cellular level, oxygen undergoes one electron reduction to superoxide through the action of differen...
Sandra Neumann,Elena G Milano,Chiara Bucciarelli-Ducci et al.
Sandra Neumann et al.
This mini review provides a concise overview of imaging techniques that are currently used to image the atheroscletoric plaque in the carotid artery in vivo. The main techniques include ultrasound imaging, X-ray imaging, magnetic resonance ...
Ambra Cappelletto,Serena Zacchigna
Ambra Cappelletto
Cardiac ischemia is the leading cause of morbidity and mortality in a worldwide epidemic. The progressive understanding of the mechanisms driving new blood vessel formation has led to numerous attempts to revascularize the ischemic heart in...
David Mellis,Andrea Caporali
David Mellis
MicroRNAs (miRNAs) are small non-coding RNAs that orchestrate genetic networks by modulating gene expression. Given their importance in vascular development, homeostasis and diseases, along with the technical feasibility in deploying their ...
Timothy D Le Cras,Elisa Boscolo
Timothy D Le Cras
The phosphoinositide 3-kinase (PI3K) pathway is a major mediator of growth factor signaling, cell proliferation and metabolism. Somatic gain-of-function mutations in PIK3CA, the catalytic subunit of PI3K, have recently been discovered in a ...