Karthik Amudhala Hemanthakumar,Riikka Kivelä
Karthik Amudhala Hemanthakumar
Endothelial cells (ECs) line the inner surface of all blood and lymphatic vessels throughout the body, making endothelium one of the largest tissues. In addition to its transport function, endothelium is now appreciated as a dynamic organ a...
Endothelial cells on the move: dynamics in vascular morphogenesis and disease [0.03%]
迁移的血管内皮细胞：在血管形态发生和疾病中的动态变化
Catarina G Fonseca,Pedro Barbacena,Claudio A Franco
Catarina G Fonseca
The vascular system is a hierarchically organized network of blood vessels that play crucial roles in embryogenesis, homeostasis and disease. Blood vessels are built by endothelial cells - the cells lining the interior of blood vessels - th...
Infrared thermography for monitoring severity and treatment of diabetic foot infections [0.03%]
红外热图在糖尿病足感染的监测、严重程度评估及治疗中的应用
Kor H Hutting,Wouter B Aan de Stegge,Rombout R Kruse et al.
Kor H Hutting et al.
Monitoring of diabetic foot infections is largely based on clinical assessment, which is limited by moderate reliability. We conducted a prospective study to explore monitoring of thermal asymmetry (difference between mean plantar temperatu...
Cristina Caffarra Malvezzi,Aderville Cabassi,Michele Miragoli
Cristina Caffarra Malvezzi
The role of mitochondria in cardiac tissue is of utmost importance due to the dynamic nature of the heart and its energetic demands, necessary to assure its proper beating function. Recently, other important mitochondrial roles have been di...
Manisha S Patil,Siân P Cartland,Mary M Kavurma
Manisha S Patil
The extracellular matrix (ECM) is an essential part of the vasculature, not only providing structural support to the blood vessel wall, but also in its ability to interact with cells to regulate cell phenotype and function including prolife...
Oscillatory fluid-induced mechanobiology in heart valves with parallels to the vasculature [0.03%]
心脏瓣膜中类似血管的振荡流体感应机械生物学特性
Chia-Pei Denise Hsu,Joshua D Hutcheson,Sharan Ramaswamy
Chia-Pei Denise Hsu
Forces generated by blood flow are known to contribute to cardiovascular development and remodeling. These hemodynamic forces induce molecular signals that are communicated from the endothelium to various cell types. The cardiovascular syst...
Molecular therapies delaying cardiovascular aging: disease- or health-oriented approaches [0.03%]
延缓心血管衰老的分子疗法：以疾病为导向还是以健康为导向的方法
Alessandra Magenta,Reggio Lorde,Sunayana Begum Syed et al.
Alessandra Magenta et al.
Regenerative medicine is a new therapeutic modality that aims to mend tissue damage by encouraging the reconstitution of physiological integrity. It represents an advancement over conventional therapies that allow reducing the damage but re...
Ruth Ganss
Ruth Ganss
Tumour growth critically depends on a supportive microenvironment, including the tumour vasculature. Tumour blood vessels are structurally abnormal and functionally anergic which limits drug access and immune responses in solid cancers. Thu...
Makeda Stephenson,Daniel H Reich,Kenneth R Boheler
Makeda Stephenson
The reproducible generation of human-induced pluripotent stem cell (hiPSC)-derived vascular smooth muscle cells (vSMCs) in vitro has been critical to overcoming many limitations of animal and primary cell models of vascular biology and dise...
The vascular epigenome in patients with obesity and type 2 diabetes: opportunities for personalized therapies [0.03%]
肥胖和二型糖尿病患者的血管表观基因组：个性化治疗的机遇
Sarah Costantino,Shafeeq A Mohammed,Samuele Ambrosini et al.
Sarah Costantino et al.
Our genetic background provides limited information on individual risk of developing vascular complications overtime. New biological layers, namely epigenetic modifications, are now emerging as potent regulators of gene expression thus lead...