Rho GTPase signalling networks in cancer cell transendothelial migration [0.03%]
癌症细胞的跨内皮迁移中的RhoGTP酶信号网络
Wessel S Rodenburg,Jaap D van Buul
Wessel S Rodenburg
Rho GTPases are small signalling G-proteins that are central regulators of cytoskeleton dynamics, and thereby regulate many cellular processes, including the shape, adhesion and migration of cells. As such, Rho GTPases are also essential fo...
The effect of absent blood flow on the zebrafish cerebral and trunk vasculature [0.03%]
缺血对斑马鱼脑部和躯干血管的影响
Elisabeth Kugler,Ryan Snodgrass,George Bowley et al.
Elisabeth Kugler et al.
The role of blood flow in vascular development is complex and context-dependent. In this study, we quantify the effect of the lack of blood flow on embryonic vascular development on two vascular beds, namely the cerebral and trunk vasculatu...
Gloria Garoffolo,Maurizio Pesce
Gloria Garoffolo
The role of mechanical forces is emerging as a new player in the pathophysiologic programming of the cardiovascular system. The ability of the cells to 'sense' mechanical forces does not relate only to perception of movement or flow, as int...
Sara Sileno,Sara Beji,Marco D&#x;Agostino et al.
Sara Sileno et al.
Psoriasis is a chronic inflammatory disease involving the skin. Both genetic and environmental factors play a pathogenic role in psoriasis and contribute to the severity of the disease. Psoriasis, in fact, has been associated with different...
The aging endothelium [0.03%]
衰老的血管内皮细胞
Ka Ka Ting,Paul Coleman,Yang Zhao et al.
Ka Ka Ting et al.
Cellular senescence is now recognized as one of the hallmarks of aging. Herein, we examine current findings on senescence of the vascular endothelium and its impacts on age-related vascular diseases. Endothelial senescence can result in sys...
Sashini Iddawela,Andrew Ravendren,Amer Harky
Sashini Iddawela
The pathophysiology of thoracic aortic aneurysm and dissection is poorly understood, despite high mortality. An evidence review was conducted to examine the biomechanical, chemical and genetic factors involved in thoracic aortic pathology. ...
SARS-CoV-2 and endothelial cell interaction in COVID-19: molecular perspectives [0.03%]
COVID-19中SARS-CoV-2与内皮细胞相互作用的分子机制研究进展
Roberta Giordo,Panagiotis Paliogiannis,Arduino Aleksander Mangoni et al.
Roberta Giordo et al.
SARS-CoV-2 is the agent responsible for the coronavirus disease (COVID-19), which has been declared a pandemic by the World Health Organization. The clinical evolution of COVID-19 ranges from asymptomatic infection to death. Older people an...
Aging- and gender-related modulation of RAAS: potential implications in COVID-19 disease [0.03%]
与年龄和性别相关的RAAS调节在COVID-19疾病中的潜在影响
Laura Monteonofrio,Maria Cristina Florio,Majd AlGhatrif et al.
Laura Monteonofrio et al.
Coronavirus disease 2019 (COVID-19) is a new infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is frequently characterized by a marked inflammatory response with severe pneumonia and respira...
MicroRNA-145 targets in cancer and the cardiovascular system: evidence for common signaling pathways [0.03%]
微RNA-145在癌症及心血管系统中的靶点：共同信号通路的证据
Dwitiya Sawant,Brenda Lilly
Dwitiya Sawant
miRNAs are small regulatory RNAs which govern gene expression post-transcriptionally by primarily binding to the 3'-UTR of mRNA target genes. miR-145 is a well-studied miRNA that has been implicated in controlling a range of biological proc...
The cardiac complications of COVID-19: many publications, multiple uncertainties [0.03%]
COVID-19的心脏并发症：许多研究，多重不确定性
Abdallah Al-Mohammad,David G Partridge,Graham Fent et al.
Abdallah Al-Mohammad et al.
Since the first description of COVID-19 in December 2019, more than 63,000 publications have described its virology, clinical course, management, treatment and prevention. Most physicians are now encountering, or will soon encounter, patien...