Vinculin strengthens the endothelial barrier during vascular development [0.03%]
血管发育期间vinculin增强内皮屏障功能
Miesje M van der Stoel,Maria P Kotini,Rianne M Schoon et al.
Miesje M van der Stoel et al.
Remodelling of cell-cell junctions is crucial for proper tissue development and barrier function. The cadherin-based adherens junctions anchor via β-catenin and α-catenin to the actomyosin cytoskeleton, together forming a junctional mecha...
Cell contractility and focal adhesion kinase control circumferential arterial stiffness [0.03%]
细胞收缩和粘着斑激酶控制环形动脉硬度
Emilia Roberts,Tina Xu,Richard K Assoian
Emilia Roberts
Arterial stiffening is a hallmark of aging and cardiovascular disease. While it is well established that vascular smooth muscle cells (SMCs) contribute to arterial stiffness by synthesizing and remodeling the arterial extracellular matrix, ...
Molecular mechanisms and effects of urocortin II on rat adventitial fibroblast calcification induced by calcified medium [0.03%]
尿皮质素Ⅱ诱导大鼠血管外膜纤维细胞钙化的分子机制及作用效应研究
Xusheng Zhang,Zhanjun Huang,Xiaorong Fan et al.
Xusheng Zhang et al.
The present study aimed to assess the role of urocortin II (UII) in the process of vascular calcification in vitro by using a calcification model, to detect the changes in the mRNA and protein levels of associated markers in rat adventitial...
Xiaojing Ma,Hongfei Li,Shuntian Zhu et al.
Xiaojing Ma et al.
The emergence of the organoid simulates the native organs and this mini organ offers an excellent platform for probing multicellular interaction, disease modeling and drug discovery. Blood vessels constitute the instructive vascular niche w...
OxLDL induces the release of IL-1β from primed human endothelial and smooth muscle cells via different caspase -1-dependent mechanisms [0.03%]
氧化低密度脂蛋白通过不同的caspase-1依赖机制诱导人内皮细胞和平滑肌细胞释放IL-1β
Majid Almansouri,Pooja Patel,Janet Chamberlain et al.
Majid Almansouri et al.
Atherosclerosis is characterised by abnormal lipid and cell accumulation within arterial layers that leads to disturbed blood flow. Modified cholesterol forms such as oxidised low-density lipoprotein (oxLDL) enter cells altering their pheno...
Go with the flow… [0.03%]
随大流……
Paul H A Quax,Marie-José T H Goumans
Paul H A Quax
SARS-CoV-2, platelets, and endothelium: coexistence in space and time, or a pernicious ménage à trois? [0.03%]
新冠病毒、血小板和血管内皮细胞：时间与空间的共存，还是一个可恶的三人行？
Vladimir Y Bogdanov,Vladimir N Khirmanov
Vladimir Y Bogdanov
As we enter year 3 of SARS-CoV-2 pandemic, long-term consequences of COVID-19 have become a major public health issue worldwide; however, the molecular and cellular underpinnings of 'long COVID' remain very poorly understood. A paradigm has...
Jordan C Langston,Michael T Rossi,Qingliang Yang et al.
Jordan C Langston et al.
During sepsis, defined as life-threatening organ dysfunction due to dysregulated host response to infection, systemic inflammation activates endothelial cells and initiates a multifaceted cascade of pro-inflammatory signaling events, result...
srGAP2 deactivates RhoA to control the duration of thrombin-mediated endothelial permeability [0.03%]
srGAP2通过使RhoA失活来控制凝血酶介导的内皮通透性的持续时间
Alba Lopez Rioja,Ashton Faulkner,Harry Mellor
Alba Lopez Rioja
The endothelial barrier is a tightly regulated gateway in the transport of material between circulation and the tissues. Inflammatory mediators such as thrombin are able to open paracellular spaces in the endothelial monolayer to allow the ...
Progerin mislocalizes myocardin-related transcription factor in Hutchinson-Guilford Progeria syndrome [0.03%]
Hutchinson-Guilford早老症中早老素引起肌生成调节因子错位分布于细胞质
Ryan von Kleeck,Paola Castagnino,Richard K Assoian
Ryan von Kleeck
Hutchinson-Guilford Progeria syndrome (HGPS) is a rare genetic disease of premature aging and early death due to cardiovascular disease. The arteries of HGPS children and mice are pathologically stiff, and HGPS mice also display reduced art...