Molecular mechanisms and effects of urocortin II on rat adventitial fibroblast calcification induced by calcified medium [0.03%]
尿皮质素Ⅱ诱导大鼠血管外膜纤维细胞钙化的分子机制及作用效应研究
Xusheng Zhang,Zhanjun Huang,Xiaorong Fan et al.
Xusheng Zhang et al.
The present study aimed to assess the role of urocortin II (UII) in the process of vascular calcification in vitro by using a calcification model, to detect the changes in the mRNA and protein levels of associated markers in rat adventitial...
Xiaojing Ma,Hongfei Li,Shuntian Zhu et al.
Xiaojing Ma et al.
The emergence of the organoid simulates the native organs and this mini organ offers an excellent platform for probing multicellular interaction, disease modeling and drug discovery. Blood vessels constitute the instructive vascular niche w...
OxLDL induces the release of IL-1β from primed human endothelial and smooth muscle cells via different caspase -1-dependent mechanisms [0.03%]
氧化低密度脂蛋白通过不同的caspase-1依赖机制诱导人内皮细胞和平滑肌细胞释放IL-1β
Majid Almansouri,Pooja Patel,Janet Chamberlain et al.
Majid Almansouri et al.
Atherosclerosis is characterised by abnormal lipid and cell accumulation within arterial layers that leads to disturbed blood flow. Modified cholesterol forms such as oxidised low-density lipoprotein (oxLDL) enter cells altering their pheno...
Go with the flow… [0.03%]
随大流……
Paul H A Quax,Marie-José T H Goumans
Paul H A Quax
SARS-CoV-2, platelets, and endothelium: coexistence in space and time, or a pernicious ménage à trois? [0.03%]
新冠病毒、血小板和血管内皮细胞：时间与空间的共存，还是一个可恶的三人行？
Vladimir Y Bogdanov,Vladimir N Khirmanov
Vladimir Y Bogdanov
As we enter year 3 of SARS-CoV-2 pandemic, long-term consequences of COVID-19 have become a major public health issue worldwide; however, the molecular and cellular underpinnings of 'long COVID' remain very poorly understood. A paradigm has...
Jordan C Langston,Michael T Rossi,Qingliang Yang et al.
Jordan C Langston et al.
During sepsis, defined as life-threatening organ dysfunction due to dysregulated host response to infection, systemic inflammation activates endothelial cells and initiates a multifaceted cascade of pro-inflammatory signaling events, result...
srGAP2 deactivates RhoA to control the duration of thrombin-mediated endothelial permeability [0.03%]
srGAP2通过使RhoA失活来控制凝血酶介导的内皮通透性的持续时间
Alba Lopez Rioja,Ashton Faulkner,Harry Mellor
Alba Lopez Rioja
The endothelial barrier is a tightly regulated gateway in the transport of material between circulation and the tissues. Inflammatory mediators such as thrombin are able to open paracellular spaces in the endothelial monolayer to allow the ...
Progerin mislocalizes myocardin-related transcription factor in Hutchinson-Guilford Progeria syndrome [0.03%]
Hutchinson-Guilford早老症中早老素引起肌生成调节因子错位分布于细胞质
Ryan von Kleeck,Paola Castagnino,Richard K Assoian
Ryan von Kleeck
Hutchinson-Guilford Progeria syndrome (HGPS) is a rare genetic disease of premature aging and early death due to cardiovascular disease. The arteries of HGPS children and mice are pathologically stiff, and HGPS mice also display reduced art...
Rethinking growth factors: the case of BMP9 during vessel maturation [0.03%]
血管成熟的骨形态发生蛋白9的生长因子作用再思考
Ferran Medina-Jover,Antoni Riera-Mestre,Francesc Viñals
Ferran Medina-Jover
Angiogenesis is an essential process for correct development and physiology. This mechanism is tightly regulated by many signals that activate several pathways, which are constantly interacting with each other. There is mounting evidence th...
Breast cancer chemotherapy vascular toxicity: a review of mediating mechanisms and exercise as a potential therapeutic [0.03%]
乳腺癌化疗的血管毒性：介导机制和运动作为一种潜在治疗手段的综述
Marie Mclaughlin,Geraint Florida-James,Mark Ross
Marie Mclaughlin
Breast cancer chemotherapy, although very potent against tumour tissue, results in significant cardiovascular toxicity. The focus of research in this area has been predominantly towards cardiotoxicity. There is limited evidence detailing th...