Should aspirin be replaced with ADP blockers and anti-GPVI to manage thrombosis? [0.03%]
应将阿司匹林替换为ADP受体拮抗剂和抗GPVI来预防血栓形成吗？
Hafsa Khan,Tahira Ghulam,Naseer Ahmed et al.
Hafsa Khan et al.
Platelets have a pivotal role in maintaining cardiovascular homeostasis. They are kept docile by endothelial-derived mediators. Aberration in haemostatic balance predisposes an individual to an elevated risk of a prothrombotic environment. ...
Søren Grubb
Søren Grubb
Neurons communicate with vasculature to regulate blood flow in the brain, a process maintained by the neurovascular unit (NVU). This interaction, termed neurovascular coupling, is believed to involve astrocytes or molecules capable of trave...
Endothelial structure contributes to heterogeneity in brain capillary diameter [0.03%]
内皮结构有助于脑毛细血管直径的异质性
Sheridan M Sargent,Stephanie K Bonney,Yuandong Li et al.
Sheridan M Sargent et al.
The high metabolic demand of brain tissue is supported by a constant supply of blood flow through dense microvascular networks. Capillaries are the smallest class of vessels in the brain and their lumens vary in diameter between ~2 and 5 μ...
Intercellular adhesion molecule 2 regulates diapedesis hotspots by allowing neutrophil crawling against the direction of flow [0.03%]
细胞间粘附分子2通过允许中性粒细胞逆流爬行来调节穿胞热点
Max L B Grönloh,Merel E Tebbens,Marianthi Kotsi et al.
Max L B Grönloh et al.
Intercellular adhesion molecules (ICAMs) are cell surface proteins that play a crucial role in the body's immune response and inflammatory processes. ICAM1 and ICAM2 are two ICAM family members expressed on the surface of various cell types...
The inhibition of Wnt signaling attenuates RANKL-induced osteoclastogenic macrophage activation [0.03%]
Wnt信号通路的抑制减弱了RANKL诱导的破骨前体细胞活化
Dai Yamanouchi,Kimihiro Igari
Dai Yamanouchi
Abdominal aortic aneurysms (AAAs) have been linked to the activation of osteoclastogenic macrophages. Reports have suggested that Wnt signaling has a dual effect of proliferation and differentiation during osteoclastogenesis. The Wnt/β-Cat...
SLC20a1/PiT-1 is required for chorioallantoic placental morphogenesis [0.03%]
SLC20A1/Pit-1对合包绒毛膜胎盘形态发生的必要性
Ana Correia-Branco,Ariel Mei,Sreehari Pillai et al.
Ana Correia-Branco et al.
The placenta mediates the transport of nutrients, such as inorganic phosphate (Pi), between the maternal and fetal circulatory systems. The placenta itself also requires high levels of nutrient uptake as it develops to provide critical supp...
BEYOND THE ENDOTHELIUM: THE ROLE OF MURAL CELLS IN VASCULAR BIOLOGY: In vitro systems to study endothelial/pericyte cell interactions [0.03%]
超出内皮细胞的范围：肌周细胞在血管生物学中的作用：研究内皮/周细胞相互作用的体外系统
Emily Warren,Sharon Gerecht
Emily Warren
The vasculature is crucial for tissue development and survival, and the stability of blood vessels to perform these functions relies on the interplay between endothelial cells (ECs) and mural cells. Pericytes are a subtype of mural cells fo...
No prominent role for complement C1-esterase inhibitor in Marfan syndrome mice [0.03%]
补体C1酯酶抑制剂在马方综合征小鼠中并不起主要作用
Stijntje Hibender,Siyu Li,Alex V Postma et al.
Stijntje Hibender et al.
Marfan syndrome (MFS) is a connective tissue disorder causing aortic aneurysm formation. Currently, only prophylactic aortic surgery and blood pressure-lowering drugs are available to reduce the risk of aortic rupture. Upon whole genome seq...
Vinculin strengthens the endothelial barrier during vascular development [0.03%]
血管发育期间vinculin增强内皮屏障功能
Miesje M van der Stoel,Maria P Kotini,Rianne M Schoon et al.
Miesje M van der Stoel et al.
Remodelling of cell-cell junctions is crucial for proper tissue development and barrier function. The cadherin-based adherens junctions anchor via β-catenin and α-catenin to the actomyosin cytoskeleton, together forming a junctional mecha...
Cell contractility and focal adhesion kinase control circumferential arterial stiffness [0.03%]
细胞收缩和粘着斑激酶控制环形动脉硬度
Emilia Roberts,Tina Xu,Richard K Assoian
Emilia Roberts
Arterial stiffening is a hallmark of aging and cardiovascular disease. While it is well established that vascular smooth muscle cells (SMCs) contribute to arterial stiffness by synthesizing and remodeling the arterial extracellular matrix, ...