Jing Chang,Christoph Rader,Haiyong Peng
Jing Chang
In vitro display technologies have been successfully utilized for the discovery and evolution of monoclonal antibodies (mAbs) for diagnostic and therapeutic applications, with phage display and yeast display being the most commonly used pla...
AB-Amy: machine learning aided amyloidogenic risk prediction of therapeutic antibody light chains [0.03%]
AB-Amy：借助机器学习预测治疗性抗体轻链淀粉样变性风险
Yuwei Zhou,Ziru Huang,Yushu Gou et al.
Yuwei Zhou et al.
Over 120 FDA-approved antibody-based therapeutics are used to treat a variety of diseases.However, many candidates could fail because of unfavorable physicochemical properties. Light-chain amyloidosis is one form of aggregation that can lea...
Efficient production of bispecific antibodies-optimization of transfection strategy leads to high-level stable cell line generation of a Fabs-in-tandem immunoglobin [0.03%]
高效生产双特异性抗体-转染策略的优化可生成高效的串联Fab片段型免疫球蛋白稳定细胞系
Shiyong Gong,Chengbin Wu
Shiyong Gong
Bispecific antibodies (bsAbs) are often composed of more than two component chains, such as Fabs-in-tandem immunoglobin (FIT-Ig) comprising three different component chains, which bring challenges for generating a high proportion of the cor...
TransMHCII: a novel MHC-II binding prediction model built using a protein language model and an image classifier [0.03%]
TransMHCII：一种基于蛋白质语言模型和图像分类器的新型MHC-II结合预测模型
Xin Yu,Christopher Negron,Lili Huang et al.
Xin Yu et al.
The emergence of deep learning models such as AlphaFold2 has revolutionized the structure prediction of proteins. Nevertheless, much remains unexplored, especially on how we utilize structure models to predict biological properties. Herein,...
Characterization of HZ0412a, a novel potent humanized anti-IL-6 receptor antibody that blocks IL-6R binding to gp130 [0.03%]
一种新型强力人源化抗白细胞介素-6受体单克隆抗体HZ0412a的表征：能阻断白细胞介素-6受体与gp130结合
Jianzhong Han,Xiaolei Liu,Yue Xu et al.
Jianzhong Han et al.
Dysregulated elevation of interleukin-6 (IL-6) signaling is implicated in the pathogenesis of multiple pathophysiological states, and the functional neutralization of the IL-6 pathway with monoclonal antibodies has been proven an effective ...
Current status of drug development for patients with multiple myeloma: a review of comparison in China and the rest of world [0.03%]
中国与世界其他地区多发性骨髓瘤患者药物研发现状比较综述
Lei Huang,Jingyu Zhang,Elizabeth Punnoose et al.
Lei Huang et al.
Multiple myeloma (MM) is a highly heterogeneous malignancy. The treatment of MM has been significantly advanced in recent years. B cell maturation antigen (BCMA)-targeted immunotherapy and chimeric antigen receptor T (CAR-T) cell therapy ha...
Rapid engineering of SARS-CoV-2 therapeutic antibodies to increase breadth of neutralization including BQ.1.1, CA.3.1, CH.1.1, XBB.1.16, and XBB.1.5 [0.03%]
快速工程化SARS-CoV-2治疗性抗体以增加对包括BQ.1.1、CA.3.1、CH.1.1、XBB.1.16和XBB.1.5在内的变体的中和广度
Kevin C Entzminger,Jonathan K Fleming,Paul D Entzminger et al.
Kevin C Entzminger et al.
SARS-CoV-2 Omicron variant XBB.1.5 has shown extraordinary immune escape even for fully vaccinated individuals. There are currently no approved antibodies that neutralize this variant, and continued emergence of new variants puts immunocomp...
Preclinical evaluation of ISH0339, a tetravalent broadly neutralizing bispecific antibody against SARS-CoV-2 with long-term protection [0.03%]
ISH0399的临床前评估，一种针对SARS-CoV-2的四价广谱中和双特异性抗体，具有长期保护作用
Huabing Yang,Yuxin Chen,Dongcheng Jiang et al.
Huabing Yang et al.
Background: Ending the global COVID-19 pandemic requires efficacious therapies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Nevertheless, the emerging Omicron sublineages largely escaped the neutr...
Beyond antibody fucosylation: α-(1,6)-fucosyltransferase (Fut8) as a potential new therapeutic target for cancer immunotherapy [0.03%]
抗体岩藻糖基化之外：α-(1,6)-岩藻糖基转移酶(Fut8)可能是癌症免疫治疗的新潜在药物靶点
Changchuin Mao,Jun Li,Lili Feng et al.
Changchuin Mao et al.
Aberrant post-translational glycosylation is a well-established hallmark of cancer. Altered core fucosylation mediated by α-(1,6)-fucosyltransferase (Fut8) is one of the key changes in tumor glycan patterns that contributes to neoplastic t...
Development of neutralizing antibodies against SARS-CoV-2, using a high-throughput single-B-cell cloning method [0.03%]
一种高通量单B细胞克隆技术促进SARS-CoV-2中和抗体的发展
Yang Dou,Ke Xu,Yong-Qiang Deng et al.
Yang Dou et al.
Background: Rapid and efficient strategies are needed to discover neutralizing antibodies (nAbs) from B cells derived from virus-infected patients. Method...