Multiple approaches to reduce reconstitution time of lyophilized drug products with high protein concentration [0.03%]
高蛋白浓度冻干药物产品的多种复溶时间缩短方法
Xiaozhang Zhang,Ningning Zhou,Chunsheng Yang et al.
Xiaozhang Zhang et al.
Background: Lyophilized drug products with high protein concentration often perform long reconstitution time, which is inconvenient for clinical use. The objective of this work is to achieve short reconstitution time with...
Effects of Fc glycosylation on the activity of WNT mimetic agonistic antibodies [0.03%]
Fc区甘cosylation对Wnt拟似激动抗体活性的影响
Hui Chen,Sung-Jin Lee,Brian Ouyang et al.
Hui Chen et al.
Monoclonal antibodies have been explored in a broad range of applications including receptor agonism. Given the importance of receptor conformation in signaling, the agonistic activity of antibodies that engage these receptors are influence...
ACE2-Fc and DPP4-Fc decoy receptors against SARS-CoV-2 and MERS-CoV variants: a quick therapeutic option for current and future coronaviruses outbreaks [0.03%]
针对SARS-CoV-2和MERS-CoV变异体的ACE2-Fc和DPP4-Fc诱饵受体：针对当前及未来冠状病毒疫情的一种快速治疗选择
Mohamed A Alfaleh,Reem M Alsulaiman,Sarah A Almahboub et al.
Mohamed A Alfaleh et al.
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and the Middle East respiratory syndrome coronavirus (MERS-CoV) are highly pathogenic human coronaviruses (CoVs). Anti-CoVs mAbs and vaccines may be effective, but the emergen...
Further accelerating biologics development from DNA to IND: the journey from COVID-19 to non-COVID-19 programs [0.03%]
从DNA到IND，进一步加快生物制剂的开发：从COVID-19项目到非COVID-19项目的过程
Kee Wee Tan,Pengfei Ji,Hang Zhou et al.
Kee Wee Tan et al.
The Coronavirus Disease (COVID-19) pandemic has spurred adoption of revolutionary initiatives by regulatory agencies and pharmaceutical industry worldwide to deliver therapeutic COVID-19 antibodies to patients at unprecedented speed. Among ...
Challenges and solutions for the downstream purification of therapeutic proteins [0.03%]
治疗蛋白下游纯化的挑战与解决方案
Shuo Tang,Jiaoli Tao,Ying Li
Shuo Tang
The innovation in recombinant protein technology has brought forth a host of challenges related to the purification of these therapeutic proteins. This article delves into the intricate landscape of developing purification processes for art...
Fc gamma receptors promote antibody-induced LILRB4 internalization and immune regulation of monocytic AML [0.03%]
Fcγ受体促进抗体诱导的LILRB4内化和单核细胞AML的免疫调节
Joshua W Morse,Xun Gui,Mi Deng et al.
Joshua W Morse et al.
The immune checkpoint leukocyte immunoglobulin-like receptor B4 (LILRB4) is found specifically on the cell surface of acute monocytic leukemia (monocytic AML), an aggressive and common subtype of AML. We have developed a humanized monoclona...
Daniel Keri,Matt Walker,Isha Singh et al.
Daniel Keri et al.
Multispecific antibodies recognize two or more epitopes located on the same or distinct targets. This added capability through protein design allows these man-made molecules to address unmet medical needs that are no longer possible with si...
CD80-Fc fusion protein as a potential cancer immunotherapy strategy [0.03%]
CD80-Fc融合蛋白作为一种潜在的癌症免疫治疗策略
Songna Wang,Pinliang Hu,Jiajun Fan et al.
Songna Wang et al.
The activation of T lymphocytes is a crucial component of the immune response, and the presence of CD80, a membrane antigen, is necessary for T-cell activation. CD80 is usually expressed on antigen-presenting cells (APCs), which can interac...
A disruptive clickable antibody design for the generation of antibody-drug conjugates [0.03%]
一种用于抗体药物偶联物生成的干扰性可点击型抗体设计法
Nathanaël Rakotoarinoro,Yan F K Dyck,Simon K Krebs et al.
Nathanaël Rakotoarinoro et al.
Background: Antibody-drug conjugates are cancer therapeutics that combine specificity and toxicity. A highly cytotoxic drug is covalently attached to an antibody that directs it to cancer cells. The conjugation of the dru...
Mapping the protein-protein interactome in the tumor immune microenvironment [0.03%]
绘制肿瘤免疫微环境中蛋白质相互作用图谱
Rui Peng,Mi Deng
Rui Peng
The cell-to-cell communication primarily occurs through cell-surface and secreted proteins, which form a sophisticated network that coordinates systemic immune function. Uncovering these protein-protein interactions (PPIs) is indispensable ...