Yanfeng Zhang,Francisca M Acosta,Jean X Jiang
Yanfeng Zhang
Connexin 43 (Cx43) protein forms hemichannels (connexons) and gap junctions, with hemichannels consisting of six Cx43 molecules and gap junctions formed by two hemichannels. While gap junctions are prevalent in organs like the heart and liv...
The process using a synthetic library that generates multiple diverse human single domain antibodies [0.03%]
利用合成文库生成多种多样的人类单结构域抗体的方法
Mark A Tornetta,Brian P Whitaker,Olivia M Cantwell et al.
Mark A Tornetta et al.
Background: Single domain antibodies (sdAbs) possess unique characteristics that make them highly effective for developing complex therapeutics. Methods: ...
AI-based antibody discovery platform identifies novel, diverse, and pharmacologically active therapeutic antibodies against multiple SARS-CoV-2 strains [0.03%]
一种基于人工智能的抗体发现平台可识别针对多种SARS-CoV-2毒株的新颖、多样且具有药理活性的治疗性抗体
Cristina Moldovan Loomis,Thomas Lahlali,Danielle Van Citters et al.
Cristina Moldovan Loomis et al.
Background: We are entering a new era of antibody discovery and optimization where machine learning (ML) processes will become indispensable for the design and development of therapeutics. ...
FcRider: a recombinant Fc nanoparticle with endogenous adjuvant activities for hybrid immunization [0.03%]
FcRider：一种具有内在佐剂活性的重组免疫纳米颗粒用于混合免疫接种
Changchuin Mao,Karen Eberle,Xiaojie Chen et al.
Changchuin Mao et al.
Active immunization (vaccination) induces long-lasting immunity with memory, which takes weeks to months to develop. Passive immunization (transfer of neutralizing antibodies) provides immediate protection, yet with high cost and effects be...
HBsAg and TLR7/8 dual-targeting antibody-drug conjugates induce sustained anti-HBV activity in AAV/HBV mice: a preliminary study [0.03%]
靶向HBsAg和TLR7/8的抗体偶联药物诱导AAV/HBV小鼠持续抗HBV作用：初步研究
Xinya Ye,Xiaoqing Chen,Han Liu et al.
Xinya Ye et al.
Hepatitis B virus (HBV) infection is a significant global health concern due to elevated immunosuppressive viral antigen levels, the host immune system's inability to manage HBV, and the liver's immunosuppressive conditions. While immunothe...
First site-specific conjugation method for native goat IgG antibodies via glycan remodeling at the conserved Fc region [0.03%]
通过Fc区糖基重构对天然山羊IgG抗体进行首个位点特异性修饰的方法
Michael E Dolan,Amissi Sadiki,Leo Lei Wang et al.
Michael E Dolan et al.
Despite their triumph in treating human diseases, antibody therapies for animals have gained momentum more slowly. However, the first approvals of animal antibodies for osteoarthritic pain in cats and dogs may herald the dawn of a new era. ...
rAbDesFlow: a novel workflow for computational recombinant antibody design for healthcare engineering [0.03%]
一种用于计算工程化重组抗体设计的新型工作流程 RabDesFlow
Sowmya Ramaswamy Krishnan,Divya Sharma,Yasin Nazeer et al.
Sowmya Ramaswamy Krishnan et al.
Recombinant antibodies (rAbs) have emerged as a promising solution to tackle antigen specificity, enhancement of immunogenic potential and versatile functionalization to treat human diseases. The development of single chain variable fragmen...
Correction to: A case study of a bispecific antibody manufacturability assessment and optimization during discovery stage and its implications [0.03%]
correction to：“发现阶段双特异性抗体可制造性研究及优化的个例分析及其意义》
[This corrects the article DOI: 10.1093/abt/tbae013.]. © The Author(s) 2024. Published by Oxford University Press on behalf of Antibody Therapeutics.
Published Erratum
Antibody therapeutics. 2024 Aug 27;7(3):281. DOI:10.1093/abt/tbae021 2024
A pan-allelic human SIRPα-blocking antibody, ES004-B5, promotes tumor killing by enhancing macrophage phagocytosis and subsequently inducing an effective T-cell response [0.03%]
全等位基因的人源化SIRPα阻断抗体ES004-B5通过增强巨噬细胞吞噬作用和随后诱导有效的T细胞反应促进肿瘤杀伤作用
Xiaofeng Niu,Chunnian Wang,Haixia Jiang et al.
Xiaofeng Niu et al.
As a major immune cell type in the tumor microenvironment, tumor-associated macrophages secrete suppressive factors that can inhibit antitumor immunity and promote tumor progression. One approach trying to utilize macrophages for immunother...
Fc engineering by monoclonal mammalian cell display for improved affinity and selectivity towards FcγRs [0.03%]
基于单克隆哺乳动物细胞展示的Fc工程改善与FcγRs结合的亲和力和特异性
Zening Wang,Minhyo Kang,Afshin Ebrahimpour et al.
Zening Wang et al.
Fc optimization can significantly enhance therapeutic efficacy of monoclonal antibodies. However, existing Fc engineering approaches are sub-optimal with noted limitations, such as inappropriate glycosylation, polyclonal libraries, and util...