Isolation of rabbit single domain antibodies to B7-H3 via protein immunization and phage display [0.03%]
利用蛋白质免疫和噬菌体展示技术分离兔源B7-H3单域抗体
Ruonan Feng,Ruixue Wang,Jessica Hong et al.
Ruonan Feng et al.
Single domain antibodies have certain advantages including their small size, high stability and excellent tissue penetration, making them attractive drug candidates. Rabbit antibodies can recognize diverse epitopes, including those that are...
[This corrects the article DOI: 10.1093/abt/tby012.][This corrects the article DOI: 10.1093/abt/tbz001.]. © The Author(s) 2019. Published by Oxford Univ...
Published Erratum
Antibody therapeutics. 2019 Jan;2(1):44. DOI:10.1093/abt/tbz006 2019
Ancient species offers contemporary therapeutics: an update on shark VNAR single domain antibody sequences, phage libraries and potential clinical applications [0.03%]
古代物种提供现代治疗手段——关于鲨鱼VNAR单域抗体序列、噬菌体展示文库和潜在临床应用的最新研究进展更新
Hejiao English,Jessica Hong,Mitchell Ho
Hejiao English
The antigen binding variable domain (VNAR) of the shark immunoglobulin new antigen receptor (IgNAR) evolved approximately 500 million years ago and it is one of the smallest antibody fragments in the animal kingdom with sizes of 12-15 kDa. ...
Next-Generation Antibody Therapeutics: Discovery, Development and Beyond: highlights of the third annual conference of the Chinese Antibody Society [0.03%]
抗体治疗药物的发现、开发及其未来——中国抗体学会2013年会会议报道及评论
Hongyu Zhang,Mi Deng,Fen Pei et al.
Hongyu Zhang et al.
The Chinese Antibody Society (CAS) convened the third annual conference in Cambridge, Massachusetts, USA on April 7, 2019. More than 600 global members attended the meeting. The theme of this conference was Next-Generation Antibody Therapeu...
'Characterization of monoclonal antibodies generated to the 287-302 amino acid loop of the human epidermal growth factor receptor' [0.03%]
人表皮生长因子受体287～302氨基酸残基组成的肽决定簇及其单克隆抗体的性质研究
Eric Chun Hei Ho,Antonella Antignani,Robert Sarnovsky et al.
Eric Chun Hei Ho et al.
Background: The dysregulation of epidermal growth factor receptor (EGFR) has been implicated in the oncogenesis of various malignancies including glioblastoma and some epithelial cancers. Oncogenesis occurs from the overe...
Dual-mechanistic antibody-drug conjugate via site-specific selenocysteine/cysteine conjugation [0.03%]
基于硒半胱氨酸/半胱氨酸定点偶联的双机制抗体药物偶联物
Napon Nilchan,Xiuling Li,Lee Pedzisa et al.
Napon Nilchan et al.
Background: While all clinically translated antibody-drug conjugates (ADCs) contain a single-drug payload, most systemic cancer chemotherapies involve use of a combination of drugs. These regimens improve treatment outcom...
Highlights of 2019 Protein Engineering Summit (PEGS) in Boston, USA: Advancing Antibody-Based Cancer Therapies to the Clinic [0.03%]
2019蛋白质工程峰会(PEGS)亮点：推进抗体偶联药物用于癌症治疗
Hong Li,You Li,Cheng Wang et al.
Hong Li et al.
The 15th Annual Protein Engineering Summit (PEGS) organized by Cambridge Healthtech Institute was held in Boston, USA from April 8th to 12th 2019. This report highlights the presentations in the Oncology Stream of this meeting with a focus ...
Generation of antibody-based therapeutics targeting the Idiotype of B-cell Malignancies [0.03%]
生成靶向B细胞恶性肿瘤Idiotype的抗体治疗药物
Emily Weiss,Robert Sarnovsky,Mitchell Ho et al.
Emily Weiss et al.
Background: A feature of many B-cell tumors is a surface-expressed immunoglobulin (sIg). The complementarity determiningregions (CDRs)of the sIg, termed the 'idiotype', are unique to each tumor. We report on a phage selec...
Construction and next-generation sequencing analysis of a large phage-displayed VNAR single-domain antibody library from six naïve nurse sharks [0.03%]
来自六只未免疫护士鲨的大型基于噬菌体展示的VNAR单域抗体库的构建和下一代测序分析
Mingqian Feng,Hejiao Bian,Xiaolin Wu et al.
Mingqian Feng et al.
Background: Shark new antigen receptor variable domain (VNAR) antibodies can bind restricted epitopes that may be inaccessible to conventional antibodies. Methods: Here, we developed a library construction method based on polymerase chain r...
Frontiers and Opportunities: Highlights of the 2nd Annual Conference of the Chinese Antibody Society [0.03%]
抗体药前沿及合作机会：中国免疫学会抗体药物专委会第二届年会精彩回顾
Hongyu Zhang,Mi Deng,Peng Lin et al.
Hongyu Zhang et al.
The Chinese Antibody Society (CAS) convened the second annual conference in Cambridge, MA, USA on 29 April 2018. More than 600 members from around the world attended the meeting. Invited speakers discussed the latest advancements in therape...