Jing Zhang,Jizu Yi,Pengfei Zhou
Jing Zhang
A bispecific antibody (bsAb) can simultaneously bind two different epitopes or antigens, allowing for multiple mechanistic functions with synergistic effects. BsAbs have attracted significant scientific attentions and efforts towards their ...
Sagacity in antibody humanization for therapeutics, diagnostics and research purposes: considerations of antibody elements and their roles [0.03%]
治疗、诊断和研究目的抗体人源化中的智慧：抗体元件及其作用的考虑因素
Wei-Li Ling,Wai-Heng Lua,Samuel Ken-En Gan
Wei-Li Ling
The humanization of antibodies for therapeutics is a critical process that can determine the success of antibody drug development. However, the science underpinning this process remains elusive with different laboratories having very differ...
Biology drives the discovery of bispecific antibodies as innovative therapeutics [0.03%]
生物学驱动双特异性抗体作为新型治疗药物的研发
Siwei Nie,Zhuozhi Wang,Maria Moscoso-Castro et al.
Siwei Nie et al.
A bispecific antibody (bsAb) is able to bind two different targets or two distinct epitopes on the same target. Broadly speaking, bsAbs can include any single molecule entity containing dual specificities with at least one being antigen-bin...
Effect of allotypic variation of human IgG1 on the thermal stability of disulfide-linked knobs-into-holes mutants of the Fc for stable bispecific antibody design [0.03%]
人IgG1所有型变异对Fc的 knobs-into-holes突变体二硫键热稳定性的影响以用于稳定双特异性抗体的设计
Hiroki Akiba,Reiko Satoh,Satoshi Nagata et al.
Hiroki Akiba et al.
Background: Disulfide-linked knobs-into-holes (dKiH) mutation is a well-validated antibody engineering technique to force heterodimer formation of different Fcs for efficient production of bispecific antibodies. An artifi...
Chimeric antigen receptor preparation from hybridoma to T-cell expression [0.03%]
从杂交瘤到T细胞表达的嵌合抗原受体制备
Hakan Köksal,Elizabeth Baken,David John Warren et al.
Hakan Köksal et al.
The successful use of chimeric antigen receptor (CAR) for hematological cancer treatment has influenced the direction taken in translational research toward an increasing focus on personalized targeted immunotherapy. Thus, a growing number ...
Induction of neutralizing antibodies by human papillomavirus vaccine generated in mammalian cells [0.03%]
由哺乳动物细胞培养的hpv疫苗诱导中和抗体产生
Xilin Wu,Xiaohua Ma,Yanlei Li et al.
Xilin Wu et al.
Background: Cervical cancer caused by human papillomavirus (HPV) infections is one of the most common cancers affecting women worldwide. Current preventative HPV vaccines on the market are composed of HPV L1 protein produ...
The 2018 Nobel Prize in Medicine for breakthroughs in targeting immune checkpoint inhibitors: a brief perspective [0.03%]
2018年诺贝尔生理学或医学奖得主及其免疫检查点抑制剂的突破性发现：一点看法
Adan Rios,Georgina To&#x;a Salazar,Ningyan Zhang et al.
Adan Rios et al.
Nathan J Alves
Nathan J Alves
In an era where ultra-high antibody concentrations, high viscosities, low volumes, auto-injectors and long storage requirements are already complex problems with the current unconjugated monoclonal antibodies on the market, the formulation ...
T-cell receptor mimic (TCRm) antibody therapeutics against intracellular proteins [0.03%]
针对胞内蛋白的T细胞受体模拟(TCRm)抗体治疗药物
Yixiang Xu,Georgina To&#x;a Salazar,Ningyan Zhang et al.
Yixiang Xu et al.
T-cell receptor mimic (TCRm) antibodies combine the capacity of a T cell to target intracellular antigens with other capacities unique to antibodies. Neoantigens are abnormal proteins that arise as a consequence of somatic mutations. Techno...