Assessing the validity of surrogate endpoints in the context of a controversy about the measurement of effectiveness of hepatitis C virus treatment [0.03%]
争议背景下评价替代终点验证性的方法——以丙型肝炎治疗为例
Claudia C Dobler,Rebecca L Morgan,Yngve Falck-Ytter et al.
Claudia C Dobler et al.
Surrogate endpoints are often used in clinical trials, as they allow for indirect measures of outcomes (eg, shorter trials with less participants). Improvements in surrogate endpoints (eg, reduction in low density lipoprotein cholesterol, n...
David R Warriner,Jack William O&#x;Sullivan
David R Warriner
Tom Jefferson,Lars Jørgensen
Tom Jefferson
Methodological quality and synthesis of case series and case reports [0.03%]
病例系列和个案报告的方法学质量及其综合方法研究
Mohammad Hassan Murad,Shahnaz Sultan,Samir Haffar et al.
Mohammad Hassan Murad et al.
Case reports and case series are uncontrolled study designs known for increased risk of bias but have profoundly influenced the medical literature and continue to advance our knowledge. In this guide, we present a framework for appraisal, s...
Carl Heneghan
Carl Heneghan
Nanda Gamad,Nusrat Shafiq,Samir Malhotra
Nanda Gamad
Angiotensin II increases blood pressure in patients with refractory vasodilatory shock [0.03%]
顽固性血管扩张性休克患者血清收缩压与血管紧张素Ⅱ水平的相关性研究
Giovanni Landoni,Alessandro Belletti
Giovanni Landoni
Low-dose levothyroxine did not improve symptoms in asymptomatic older people with subclinical hypothyroidism [0.03%]
小剂量左旋甲状腺素不能改善亚临床甲状腺功能减退无症状老年人的症状
Simon H S Pearce,Earn H Gan
Simon H S Pearce
Trial supports targeted radiotherapy for early breast cancer but protocol still requires 3 weeks of daily therapy [0.03%]
试验支持了乳腺癌的靶向放疗但每周仍需接受为期三天的治疗
Jayant S Vaidya,Frederik Wenz,Jeffrey S Tobias
Jayant S Vaidya