Subhajit Karmakar,Mouli Chatterjee,Malini Basu et al.
Subhajit Karmakar et al.
STUB1, also known as CHIP (C-terminus of Hsc70-Interacting Protein), plays a vital role in cellular protein homeostasis through its E3 ubiquitin ligase activity. Recent evidence suggests that STUB1 (CHIP) is implicated in various cancer typ...
DeSciDe: a tool for unbiased literature searching and gene list curation unveils a new role for the acidic patch mutation H2A E92K [0.03%]
DeSciDe：一种无偏见的文献搜索和基因列表整理工具，揭示了酸性补丁突变H2A E92K的新作用
Cameron J Douglas,Ciaran P Seath
Cameron J Douglas
Omics analysis has become an indispensable tool for researchers in the life sciences, enabling the study of DNA, RNA, and proteins and how they respond to cellular stimulus. Many methods of data analysis exist for the generation and charact...
Mapping the Helichrysum metabolome: uncovering species-specific chemistry through an AI-guided LC-MS/MS workflow [0.03%]
应用AI指导的LC-MS/MS工作流程绘制固丝草属次级代谢轮廓并发现物种特异性化学物质
Motseoa Mariam Lephatsi,Mpho Susan Choene,Abidemi Paul Kappo et al.
Motseoa Mariam Lephatsi et al.
Helichrysum species, of which 35% are native to South Africa, are renowned for their diverse medicinal properties, yet their chemical composition remains largely unexplored. As such, continuous efforts are needed to comprehensively characte...
Hypoxia-induced alterations in lipid polyunsaturation and associated proteins drive aggressive metastasis in pancreatic cancer via the PPAR/hypoxia pathway [0.03%]
缺氧诱导的脂质多不饱和及相关的蛋白质通过PPAR/缺氧通路驱动胰腺癌侵袭性转移
Prema Kumari Agarwala,Avinash Singh,Sanjeeva Srivastava et al.
Prema Kumari Agarwala et al.
In pancreatic ductal adenocarcinoma, hypoxia is a crucial component of the tumour microenvironment and is associated with worse clinical outcomes. Adaptation to extreme hypoxic settings is based on abnormal lipid metabolism, but insights in...
Global spinal cord peptidome profiling in response to osteoarthritis in rats [0.03%]
大鼠脊髓肽图谱对骨关节炎的响应分析
Gaoyuan Lu,Marilyn Frézier,Colombe Otis et al.
Gaoyuan Lu et al.
Osteoarthritis (OA) is a complex and increasingly prevalent condition, affecting an estimated 600 million people worldwide and significantly reducing quality of life. Understanding OA as both an inflammatory and neurological disease present...
Eitan Erez Zahavi,Ida Rishal,Juan A Oses-Prieto et al.
Eitan Erez Zahavi et al.
AS1411 is a G-rich DNA aptamer that targets the multifunctional RNA-binding protein nucleolin. AS1411 has both antiproliferative and cell size-regulating activities and has been evaluated for clinical utility, reaching phase II trials as an...
Mass spectrometry-based profiling of phosphoinositide: advances, challenges, and future directions [0.03%]
基于质谱的磷脂肌醇分析：进展、挑战与未来方向
Yuki Ishino,Yuta Shimanaka,Junken Aoki et al.
Yuki Ishino et al.
Phosphoinositides (PIPs), the phosphorylated derivatives of phosphatidylinositol (PI), are low-abundance yet critical components of eukaryotic membranes. They play pivotal roles in a wide array of cellular processes, including signal transd...
The omics revolution in obesity: from molecularsignatures to clinical solutions [0.03%]
肥胖的组学革命：从中分子特征到临床解决方案
Mohammad Mustafa,Amr A Arafat,Waleed Alhazzani et al.
Mohammad Mustafa et al.
Obesity is a multifactorial condition projected to affect over half of the global population by 2035, posing significant clinical and socioeconomic challenges. Traditional metrics such as body mass index lack precision in predicting individ...
Cytokine-induced memory-like responses in endothelial cells link chronic inflammation to vascular disease risk [0.03%]
细胞因子诱导的内皮细胞记忆反应连接慢性炎症与血管疾病风险
Kieu T T Le,Nick Keur,Heleen Middelkamp et al.
Kieu T T Le et al.
Chronic inflammation plays a central role in the progression of both infectious and vascular diseases, yet its impact on endothelial cells (ECs), which form the interface between blood and tissue, remains poorly understood. Given their cons...
An altered proteome in ovarian cancer stem-like cells: profiling of the mDivi-1 induced proteome and its clinical significance [0.03%]
卵巢癌干细胞样细胞的蛋白质组改变：mdivi-1诱导蛋白组分析及其临床意义
Manita Raina,Tejan Lodhiya,Rahail Ashraf et al.
Manita Raina et al.
A three-dimensional (3D) spheroid culture mimics in vivo conditions and reproduces the tumor microenvironment, thus providing more physiological relevance to disease conditions. Mapping the proteome profile in 3D-cultured ovarian cancer (OC...