Metabolite-centric identification of antimetabolite drug targets across cancer and neurodegenerative diseases [0.03%]
以代谢物为核心的抗代谢药物靶点在癌症和神经退行性疾病中的识别方法
Regan Odongo,Tunahan Çakır
Regan Odongo
Antimetabolites, primarily studied in cancer, are novel drugs targeting metabolic networks by mimicking and inhibiting disease-causing metabolites, enabling poly-pharmacologic effects essential for complex diseases. Moreover, predicting pat...
Platelet proteomics on less than a drop of previously frozen, non-citrate plasma [0.03%]
少于一滴之前被冷冻的无柠檬酸盐血浆的血小板蛋白质组学
Dylan Nicholas Tabang,Kathrin Korff,Kaitlyn Brannon et al.
Dylan Nicholas Tabang et al.
Platelets are blood components not regularly analysed with proteomics due to the conventional wisdom that plasma for platelet research must be citrate-treated and freshly sampled to minimize artifactual changes. Information from platelets i...
Decoding the Diabetic Transition: A Lipidomic Approach for Biomarker Discovery in an Indian Cohort [0.03%]
糖尿病脂质组学标志物的发现与验证研究
Sneha Singh,Rekha Nagpal,Ashutosh Kumar
Sneha Singh
Type 2 Diabetes Mellitus (T2DM) is a significant public health burden in India, where the disease presents with unique clinical characteristics, yet data from this high-risk population remain scarce. This study aimed to conduct a lipidomic ...
Placental metabolomics for assessment of pregnancy complications: a systematic review [0.03%]
胎盘代谢组学在评估妊娠并发症方面的应用：系统评价
Grace V Mercer,Lindsay S Cahill
Grace V Mercer
Metabolomics is a powerful tool for understanding biological function at the cellular level. While this omics technology has found application in areas ranging from toxicology to cancer, its potential for the study of human pregnancy compli...
Prostate cancer: metabolic remodelling in expressed prostatic secretions reveals cellular structural changes measured by mpMRI [0.03%]
前列腺癌：表达前列腺分泌物中的代谢重构及mpMRI测量的细胞结构变化
Anuj Kumar,Ashish Ranjan,Aniket Anand et al.
Anuj Kumar et al.
Early and accurate differentiation of prostate cancer (PC) from benign prostatic hyperplasia (BPH) remains challenging; metabolomics enables biomarker discovery by capturing disease-specific metabolic changes. The study includes 64 expresse...
A Practical Guide to Experimental Design and Power Analysis for Metaproteomics Studies [0.03%]
甲基化蛋白质组学研究的实验设计和功效分析实用指南
Luman Wang,Qianyi Zhou,Yutong Li et al.
Luman Wang et al.
Metaproteomics is an effective tool for characterizing the functional profiles of microbial communities by directly measuring protein expression. However, prospective power analysis and sample-size estimation are often overlooked at the stu...
Green synthesis of silver nanoparticles using Padina tetrastromatica against malaria and deciphering the mechanism through machine learning driven metabolomics and network pharmacology [0.03%]
利用Padina tetrastromatica绿色合成银纳米颗粒对抗疟疾及通过机器学习驱动的代谢组学和网络药理学揭示其作用机制
Nikhila Yaladanda,Yashwanth Kumar Budige,Dileepkumar Veeragoni et al.
Nikhila Yaladanda et al.
Malaria remains a major public health challenge due to drug and insecticide resistance, underscoring the need for novel therapies with distinct mechanisms of action. In this study, silver nanoparticles were green-synthesized using the brown...
Native PGC-LC-MS profiling reveals distinct O-acetylation patterns of Sialylated N-glycans across mammalian sera [0.03%]
原发性PGC-LC-MS特征分析揭示了哺乳动物血清中唾液酸糖蛋白N-连接聚糖O-乙酰化修饰的独特模式
Christopher Ashwood
Christopher Ashwood
O-acetylation of sialic acids represents an additional layer of structural diversity and biological complexity, occurring at various hydroxyl positions (commonly C-7, C-8, or C-9) of the sialic acid residue. This modification modulates the ...
Need for speed: Advances in the era of high throughput interaction proteomics [0.03%]
飞速前进：高通量相互作用蛋白质组学时代的技术进展
Fabian Frommelt,Uliana Federico,Ruedi Aebersold et al.
Fabian Frommelt et al.
Protein-protein interactions are central to virtually all biological processes, forming intricate networks that operate in a highly regulated manner. These interactions are not permanent but rather continuously adapt to environmental change...
Grisna Isabel Prensa,Andrea Garca Navarro,David Parker et al.
Grisna Isabel Prensa et al.
Investigating host-pathogen interactions at the molecular level is critical for understanding infection mechanisms and identifying potential therapeutic targets. Mass spectrometry (MS)-based proteomics has rapidly become one of the most emp...