Bridge-Like Lipid Transfer Proteins (BLTPs) in C. elegans: From Genetics to Structures and Functions [0.03%]
从遗传学到结构与功能的线虫桥脂质转运蛋白(BLTPs)研究
Taruna Pandey,Jianxiu Zhang,Bingying Wang et al.
Taruna Pandey et al.
In eukaryotic cells, lipid transfer can occur at membrane contact sites (MCS) to facilitate the exchange of various lipids between two adjacent cellular organelle membranes. Lipid transfer proteins (LTPs), including shuttle LTP or bridge-li...
Stranger Twins: A Tale of Resemblance and Contrast Between VAP Proteins [0.03%]
陌生意双生子：血管生成抑制蛋白家族成员的相似性与差异性故事
Mélody Subra,Zoé Grimanelli,Romain Gautier et al.
Mélody Subra et al.
When considering the vesicle-associated membrane protein-associated protein (VAP) family, major receptors at the surface of the endoplasmic reticulum (ER), it appears that VAP-A and VAP-B paralogs largely overlap in structure and function, ...
Bacterial AsmA-Like Proteins: Bridging the Gap in Intermembrane Phospholipid Transport [0.03%]
细菌AsmA样蛋白：跨膜磷脂转运的缺失环节
Sujeet Kumar,Natividad Ruiz
Sujeet Kumar
In eukaryotic cells, nonvesicular lipid transport between organelles is mediated by lipid-transfer proteins. Recently, a new class of these lipid transporters has been described to facilitate the bulk of inter-organelle lipid transport at c...
IP3R at ER-Mitochondrial Contact Sites: Beyond the IP3R-GRP75-VDAC1 Ca2+ Funnel [0.03%]
ER-线粒体接触部位的IP3受体：IP3受体-GRP75-电压依赖性阴离子通道1钙通道之外的功能
Peace Atakpa-Adaji,Adelina Ivanova
Peace Atakpa-Adaji
Membrane contact sites (MCS) circumvent the topological constraints of functional coupling between different membrane-bound organelles by providing a means of communication and exchange of materials. One of the most characterised contact si...
Molecular Regulations of FUNDC1 at ER-Mitochondria Contacts Under Hypoxic Stress [0.03%]
缺氧应激下内质网-线粒体接触点处FUNDC1的分子调控机制研究
Yi Zhang,Haixia Zhuang,Hao Liu et al.
Yi Zhang et al.
A recent research paper published in Journal of Cell Biology by Chen and colleagues describes a novel mechanism by which the MAM (Mitochondrial-associated endoplasmic reticulum membrane) protein FUNDC1 (FUN14 domain-containing protein 1) re...
Sorting (Nexin-13) out Novel Insights into Endolysosomal Cholesterol Export [0.03%]
新型内体/溶酶体胆固醇流出机制的见解——排“nexin-13”名
Albert Lu
Albert Lu
Transport in and out of the endolysosomal compartment represents a key step in the regulation of cellular cholesterol homeostasis. Despite important recent advances, how LDL-derived, free cholesterol is exported from the lumen of endolysoso...
Hannah Casbolt,Michelangelo Campanella
Hannah Casbolt
Apicoplasts are critical for the growth of medically important parasites. It is now reported that they form contacts with the endoplasmic reticulum (ER) via two pore channels thus enabling Ca2+ trafficking. This highlights the dynamic physi...
The PH-like Domain of VPS13 Proteins - a Determinant of Localization to the Golgi Apparatus or to the Plasma Membrane [0.03%]
VPS13蛋白的PH样结构域-定位到高尔基体或质膜的决定因素
Joanna Kaminska
Joanna Kaminska
Mutations in the four human genes VPS13A-D, encoding vacuolar protein sorting 13 (VPS13A-D) proteins, result in developmental or neurodegenerative diseases. Understanding the functioning of VPS13 proteins in physiology and pathology is a ho...
Regulation of Endosomal Sorting and Maturation by ER-Endosome Contact Sites [0.03%]
内质网-胞内体接触位点对胞内体分拣和成熟的作用机制研究
Steve Jean,Sonya Nassari
Steve Jean
Endosomes are a heterogeneous population of intracellular organelles responsible for sorting, recycling, or transporting internalized materials for degradation. Endosomal sorting and maturation are controlled by a complex interplay of regul...
α-Synuclein Interactions in Mitochondria-ER Contacts: A Possible Role in Parkinson's Disease [0.03%]
帕金森病发病机制中线粒体-内质网互作中的α-突触核蛋白作用研究
Adolfo Garcia Erustes,Gabriel Cicolin Guarache,Erika da Cruz Guedes et al.
Adolfo Garcia Erustes et al.
Endoplasmic reticulum-mitochondria contact sites regulate various biological processes, such as mitochondrial dynamics, calcium homeostasis, autophagy and lipid metabolism. Notably, dysfunctions in these contact sites are closely related to...