Erythroid Differentiation Dependent Interaction of VPS13A with XK at the Plasma Membrane of K562 Cells [0.03%]
VPS13A与K562细胞浆膜上XK的红系分化依赖互作
Chase Amos,Peng Xu,Pietro De Camilli
Chase Amos
Mutations of the bridge-like lipid transport protein VPS13A and the lipid scramblase XK result in Chorea Acanthocytosis (ChAc) and McLeod syndrome (MLS), respectively, two similar conditions involving neurodegeneration and deformed erythroc...
Ruth H Walker,Kevin Peikert,Hans H Jung et al.
Ruth H Walker et al.
The two very rare neurodegenerative diseases historically known as the "neuroacanthocytosis syndromes" are due to mutations of either VPS13A or XK. These are phenotypically similar disorders that affect primarily the basal ganglia and hence...
A Possible Role of VPS13B in the Formation of Golgi-Lipid Droplet Contacts Associating with the ER [0.03%]
VPS13B在高尔基体-脂滴与内质网接触形成中的可能作用
Yuanjiao Du,Xuewen Hu,Weiping Chang et al.
Yuanjiao Du et al.
While the physical interactions between the Golgi apparatus (Golgi) and lipid droplets (LDs) have been suggested through system-level imaging, the Golgi-LD membrane contact sites (MCSs) remain largely uncharacterized. Here, we show evidence...
Phylogenetic and Structural Analyses of VPS13 Proteins in Archaeplastida Reveal Their Complex Evolutionary History in Viridiplantae [0.03%]
蛋白磷酸酶2C家族的系统发育及结构分析揭示了其在绿色植物中的复杂进化历程
Sébastien Leterme,Olivier Bastien,Riccardo Aiese Cigliano et al.
Sébastien Leterme et al.
VPS13 is a lipid transfer protein family conserved among Eukaryotes and playing roles in fundamental processes involving vesicular transport and membrane expansion including autophagy and organelle biogenesis. VPS13 folds into a long hydrop...
Canonical and Non-Canonical Roles of SNX1 and SNX2 in Endosomal Membrane Dynamics [0.03%]
SNX1和SNX2在胞内膜动态中的正典与非典作用
Juliane Da Graça,Etienne Morel
Juliane Da Graça
Sorting nexins (SNXs) are a family of membrane-binding proteins known to play a critical role in regulating endocytic pathway sorting and endosomal membrane trafficking. Among them, SNX1 and SNX2 are members of the SNX-BAR subfamily and pos...
A Role for Two-Pore Channel Type 2 (TPC2)-Mediated Regulation of Membrane Contact Sites During Zebrafish Notochord Biogenesis? [0.03%]
二孔通道蛋白2（TPC2）介导的膜接触位点调节在斑马鱼体节发生中的作用？
Keira L Rice,Ching Man Chan,Jeffrey J Kelu et al.
Keira L Rice et al.
We have previously shown that in the developing trunk of zebrafish embryos, two-pore channel type 2 (TPC2)-mediated Ca2+ release from endolysosomes plays a role in the formation of the skeletal slow muscle. In addition, TPC2-mediated Ca2+ s...
Lena Clausmeyer,Florian Fröhlich
Lena Clausmeyer
Ceramides, as key components of cellular membranes, play essential roles in various cellular processes, including apoptosis, cell proliferation, and cell signaling. Ceramides are the precursors of all complex sphingolipids in eukaryotic cel...
Interorganellar Communication Through Membrane Contact Sites in Toxoplasma Gondii [0.03%]
刚地弓形虫膜接触位点介导的内 organellar 通讯
Diego Huet,Silvia N J Moreno
Diego Huet
Apicomplexan parasites are a group of protists that cause disease in humans and include pathogens like Plasmodium spp., the causative agent of malaria, and Toxoplasma gondii, the etiological agent of toxoplasmosis and one of the most ubiqui...
E-Syt1 Regulates Neuronal Activity-Dependent Endoplasmic Reticulum-Plasma Membrane Junctions and Surface Expression of AMPA Receptors [0.03%]
E-Syt1调节神经元活动依赖的内质网-细胞膜连接和AMPA受体表面表达
Ranran Mao,Chunfang Tong,Jia-Jia Liu
Ranran Mao
Endoplasmic reticulum (ER)-plasma membrane (PM) contact sites/junctions play important roles in cell physiology including signal transduction, ion and lipid transfer, and membrane dynamics. However, little is known about the dynamic regulat...
Prado Vargas Duarte,Fulvio Reggiori
Prado Vargas Duarte
Macroautophagy is characterized by the de novo formation of double-membrane vesicles termed autophagosomes. The precursor structure of autophagosomes is a membrane cistern called phagophore, which elongates through a massive acquisition of ...