A Role for Two-Pore Channel Type 2 (TPC2)-Mediated Regulation of Membrane Contact Sites During Zebrafish Notochord Biogenesis? [0.03%]
二孔通道蛋白2（TPC2）介导的膜接触位点调节在斑马鱼体节发生中的作用？
Keira L Rice,Ching Man Chan,Jeffrey J Kelu et al.
Keira L Rice et al.
We have previously shown that in the developing trunk of zebrafish embryos, two-pore channel type 2 (TPC2)-mediated Ca2+ release from endolysosomes plays a role in the formation of the skeletal slow muscle. In addition, TPC2-mediated Ca2+ s...
Lena Clausmeyer,Florian Fröhlich
Lena Clausmeyer
Ceramides, as key components of cellular membranes, play essential roles in various cellular processes, including apoptosis, cell proliferation, and cell signaling. Ceramides are the precursors of all complex sphingolipids in eukaryotic cel...
Interorganellar Communication Through Membrane Contact Sites in Toxoplasma Gondii [0.03%]
刚地弓形虫膜接触位点介导的内 organellar 通讯
Diego Huet,Silvia N J Moreno
Diego Huet
Apicomplexan parasites are a group of protists that cause disease in humans and include pathogens like Plasmodium spp., the causative agent of malaria, and Toxoplasma gondii, the etiological agent of toxoplasmosis and one of the most ubiqui...
E-Syt1 Regulates Neuronal Activity-Dependent Endoplasmic Reticulum-Plasma Membrane Junctions and Surface Expression of AMPA Receptors [0.03%]
E-Syt1调节神经元活动依赖的内质网-细胞膜连接和AMPA受体表面表达
Ranran Mao,Chunfang Tong,Jia-Jia Liu
Ranran Mao
Endoplasmic reticulum (ER)-plasma membrane (PM) contact sites/junctions play important roles in cell physiology including signal transduction, ion and lipid transfer, and membrane dynamics. However, little is known about the dynamic regulat...
Prado Vargas Duarte,Fulvio Reggiori
Prado Vargas Duarte
Macroautophagy is characterized by the de novo formation of double-membrane vesicles termed autophagosomes. The precursor structure of autophagosomes is a membrane cistern called phagophore, which elongates through a massive acquisition of ...
Bridge-Like Lipid Transfer Proteins (BLTPs) in C. elegans: From Genetics to Structures and Functions [0.03%]
从遗传学到结构与功能的线虫桥脂质转运蛋白(BLTPs)研究
Taruna Pandey,Jianxiu Zhang,Bingying Wang et al.
Taruna Pandey et al.
In eukaryotic cells, lipid transfer can occur at membrane contact sites (MCS) to facilitate the exchange of various lipids between two adjacent cellular organelle membranes. Lipid transfer proteins (LTPs), including shuttle LTP or bridge-li...
Stranger Twins: A Tale of Resemblance and Contrast Between VAP Proteins [0.03%]
陌生意双生子：血管生成抑制蛋白家族成员的相似性与差异性故事
Mélody Subra,Zoé Grimanelli,Romain Gautier et al.
Mélody Subra et al.
When considering the vesicle-associated membrane protein-associated protein (VAP) family, major receptors at the surface of the endoplasmic reticulum (ER), it appears that VAP-A and VAP-B paralogs largely overlap in structure and function, ...
Bacterial AsmA-Like Proteins: Bridging the Gap in Intermembrane Phospholipid Transport [0.03%]
细菌AsmA样蛋白：跨膜磷脂转运的缺失环节
Sujeet Kumar,Natividad Ruiz
Sujeet Kumar
In eukaryotic cells, nonvesicular lipid transport between organelles is mediated by lipid-transfer proteins. Recently, a new class of these lipid transporters has been described to facilitate the bulk of inter-organelle lipid transport at c...
IP3R at ER-Mitochondrial Contact Sites: Beyond the IP3R-GRP75-VDAC1 Ca2+ Funnel [0.03%]
ER-线粒体接触部位的IP3受体：IP3受体-GRP75-电压依赖性阴离子通道1钙通道之外的功能
Peace Atakpa-Adaji,Adelina Ivanova
Peace Atakpa-Adaji
Membrane contact sites (MCS) circumvent the topological constraints of functional coupling between different membrane-bound organelles by providing a means of communication and exchange of materials. One of the most characterised contact si...
Molecular Regulations of FUNDC1 at ER-Mitochondria Contacts Under Hypoxic Stress [0.03%]
缺氧应激下内质网-线粒体接触点处FUNDC1的分子调控机制研究
Yi Zhang,Haixia Zhuang,Hao Liu et al.
Yi Zhang et al.
A recent research paper published in Journal of Cell Biology by Chen and colleagues describes a novel mechanism by which the MAM (Mitochondrial-associated endoplasmic reticulum membrane) protein FUNDC1 (FUN14 domain-containing protein 1) re...