OSBP is a Major Determinant of Golgi Phosphatidylinositol 4-Phosphate Homeostasis [0.03%]
OSBP是高尔基体磷脂酰肌醇4-磷酸稳态的主要决定因素
Colleen P Doyle,Liz Timple,Gerald R V Hammond
Colleen P Doyle
The lipid phosphatidylinositol 4-phosphate (PI4P) plays a master regulatory role at Golgi membranes, orchestrating membrane budding, non-vesicular lipid transport and membrane organization. It follows that harmonious Golgi function requires...
Supralinear Dependence of the IP3 Receptor-to-Mitochondria Local Ca2+ Transfer on the Endoplasmic Reticulum Ca2+ Loading [0.03%]
内质网钙超载对IP3受体-线粒体局部钙传递的超线性依赖关系
György Csordás,David Weaver,Péter Várnai et al.
György Csordás et al.
Calcium signal propagation from endoplasmic reticulum (ER) to mitochondria regulates a multitude of mitochondrial and cell functions, including oxidative ATP production and cell fate decisions. Ca2+ transfer is optimal at the ER-mitochondri...
Gaiti Hasan
Gaiti Hasan
All living organisms need to respond appropriately to changes in the extracellular milieu. Cellular mechanisms that enable such responses evolved in parallel with organismal complexity and intracellular Ca2+ signaling is one such mechanism ...
Contact-FP: A Dimerization-Dependent Fluorescent Protein Toolkit for Visualizing Membrane Contact Site Dynamics [0.03%]
Contact-FP：一种用于可视化膜接触位点动态变化的二聚体依赖性荧光蛋白工具包
Gregory E Miner,Sidney Y Smith,Wendy K Showalter et al.
Gregory E Miner et al.
Membrane contact sites (MCSs) are sites of close apposition between two organelles used to exchange ions, lipids, and information. Cells respond to changing environmental or developmental conditions by modulating the number, extent, or dura...
Orthogonal Targeting of SAC1 to Mitochondria Implicates ORP2 as a Major Player in PM PI4P Turnover [0.03%]
SAC1的正交靶向到线粒体表明ORP2是PM PI4P降解的重要参与者
Colleen P Doyle,Andrew Rectenwald,Liz Timple et al.
Colleen P Doyle et al.
Oxysterol-binding protein (OSBP)-related proteins (ORPs) 5 and 8 have been shown to deplete the lipid phosphatidylinositol 4-phosphate (PI4P) at sites of membrane contact between the endoplasmic reticulum (ER) and plasma membrane (PM). This...
Erythroid Differentiation Dependent Interaction of VPS13A with XK at the Plasma Membrane of K562 Cells [0.03%]
VPS13A与K562细胞浆膜上XK的红系分化依赖互作
Chase Amos,Peng Xu,Pietro De Camilli
Chase Amos
Mutations of the bridge-like lipid transport protein VPS13A and the lipid scramblase XK result in Chorea Acanthocytosis (ChAc) and McLeod syndrome (MLS), respectively, two similar conditions involving neurodegeneration and deformed erythroc...
Ruth H Walker,Kevin Peikert,Hans H Jung et al.
Ruth H Walker et al.
The two very rare neurodegenerative diseases historically known as the "neuroacanthocytosis syndromes" are due to mutations of either VPS13A or XK. These are phenotypically similar disorders that affect primarily the basal ganglia and hence...
A Possible Role of VPS13B in the Formation of Golgi-Lipid Droplet Contacts Associating with the ER [0.03%]
VPS13B在高尔基体-脂滴与内质网接触形成中的可能作用
Yuanjiao Du,Xuewen Hu,Weiping Chang et al.
Yuanjiao Du et al.
While the physical interactions between the Golgi apparatus (Golgi) and lipid droplets (LDs) have been suggested through system-level imaging, the Golgi-LD membrane contact sites (MCSs) remain largely uncharacterized. Here, we show evidence...
Phylogenetic and Structural Analyses of VPS13 Proteins in Archaeplastida Reveal Their Complex Evolutionary History in Viridiplantae [0.03%]
蛋白磷酸酶2C家族的系统发育及结构分析揭示了其在绿色植物中的复杂进化历程
Sébastien Leterme,Olivier Bastien,Riccardo Aiese Cigliano et al.
Sébastien Leterme et al.
VPS13 is a lipid transfer protein family conserved among Eukaryotes and playing roles in fundamental processes involving vesicular transport and membrane expansion including autophagy and organelle biogenesis. VPS13 folds into a long hydrop...
Canonical and Non-Canonical Roles of SNX1 and SNX2 in Endosomal Membrane Dynamics [0.03%]
SNX1和SNX2在胞内膜动态中的正典与非典作用
Juliane Da Graça,Etienne Morel
Juliane Da Graça
Sorting nexins (SNXs) are a family of membrane-binding proteins known to play a critical role in regulating endocytic pathway sorting and endosomal membrane trafficking. Among them, SNX1 and SNX2 are members of the SNX-BAR subfamily and pos...