Nucleus-Mitochondria Contact Sites Are Associated With Asynthetic Fission in Zebrafish Skin [0.03%]
斑马鱼皮肤中的核-线粒体接触位点与非合成性分裂相关
Dhani Tracey-White,Matthew J Hayes
Dhani Tracey-White
Rapid increase in body surface area of growing zebrafish larvae (Danio rario) is partially accomplished by asynthetic fission of superficial epithelial cells (SECs) of the skin. There are two cycles of this atypical form of cell division wh...
DGARM/C10orf76/ARMH3 for Ceramide Transfer Zone at the Endoplasmic Reticulum-Distal Golgi Contacts [0.03%]
DGARM/C10orf76/ARMH3为内质网-高尔基复合体远端囊泡接触位点的鞘氨醇酰胺转移区
Aya Mizuike,Kentaro Hanada
Aya Mizuike
Phosphatidylinositol 4-monophosphate (PtdIns(4)P) is one of the key membrane components which mark the membrane contact sites. In the mammalian Golgi complex, PtdIns(4)P is produced at various subregions via specific mechanisms for each sit...
Editorial on Special Collection in Contact: VPS13 and Bridge-Like Lipid Transfer Proteins: A New Mode of Intracellular Continuity [0.03%]
专题论文集述评：VPS13和桥状脂质转运蛋白：细胞内连续性的一种新方式
Tim P Levine,Liz Conibear
Tim P Levine
Hau Lam Choy,Elizabeth Anne Gaylord,Tamara Lea Doering
Hau Lam Choy
Cryptococcus neoformans is an important fungal pathogen, responsible for over 140,000 deaths per year worldwide. Like other yeasts, C. neoformans relies on ergosterol as its major membrane sterol and carefully regulates its synthesis and di...
C ool-contacts: Cryo-Electron Microscopy of Membrane Contact Sites and Their Components [0.03%]
膜接触位点及其组分的冷冻电子显微镜分析
Cyan Ching,Julien Maufront,Aurélie di Cicco et al.
Cyan Ching et al.
Electron microscopy has played a pivotal role in elucidating the ultrastructure of membrane contact sites between cellular organelles. The advent of cryo-electron microscopy has ushered in the ability to determine atomic models of constitue...
OSBP is a Major Determinant of Golgi Phosphatidylinositol 4-Phosphate Homeostasis [0.03%]
OSBP是高尔基体磷脂酰肌醇4-磷酸稳态的主要决定因素
Colleen P Doyle,Liz Timple,Gerald R V Hammond
Colleen P Doyle
The lipid phosphatidylinositol 4-phosphate (PI4P) plays a master regulatory role at Golgi membranes, orchestrating membrane budding, non-vesicular lipid transport and membrane organization. It follows that harmonious Golgi function requires...
Supralinear Dependence of the IP3 Receptor-to-Mitochondria Local Ca2+ Transfer on the Endoplasmic Reticulum Ca2+ Loading [0.03%]
内质网钙超载对IP3受体-线粒体局部钙传递的超线性依赖关系
György Csordás,David Weaver,Péter Várnai et al.
György Csordás et al.
Calcium signal propagation from endoplasmic reticulum (ER) to mitochondria regulates a multitude of mitochondrial and cell functions, including oxidative ATP production and cell fate decisions. Ca2+ transfer is optimal at the ER-mitochondri...
Gaiti Hasan
Gaiti Hasan
All living organisms need to respond appropriately to changes in the extracellular milieu. Cellular mechanisms that enable such responses evolved in parallel with organismal complexity and intracellular Ca2+ signaling is one such mechanism ...
Contact-FP: A Dimerization-Dependent Fluorescent Protein Toolkit for Visualizing Membrane Contact Site Dynamics [0.03%]
Contact-FP：一种用于可视化膜接触位点动态变化的二聚体依赖性荧光蛋白工具包
Gregory E Miner,Sidney Y Smith,Wendy K Showalter et al.
Gregory E Miner et al.
Membrane contact sites (MCSs) are sites of close apposition between two organelles used to exchange ions, lipids, and information. Cells respond to changing environmental or developmental conditions by modulating the number, extent, or dura...
Orthogonal Targeting of SAC1 to Mitochondria Implicates ORP2 as a Major Player in PM PI4P Turnover [0.03%]
SAC1的正交靶向到线粒体表明ORP2是PM PI4P降解的重要参与者
Colleen P Doyle,Andrew Rectenwald,Liz Timple et al.
Colleen P Doyle et al.
Oxysterol-binding protein (OSBP)-related proteins (ORPs) 5 and 8 have been shown to deplete the lipid phosphatidylinositol 4-phosphate (PI4P) at sites of membrane contact between the endoplasmic reticulum (ER) and plasma membrane (PM). This...