Store-Operated Ca2+ Entry in Fibrosis and Tissue Remodeling [0.03%]
纤维化和组织重塑中的 store-operated 钙离子进入现象
Ahmed Emam Abdelnaby,Mohamed Trebak
Ahmed Emam Abdelnaby
Fibrosis is a pathological condition characterized by excessive tissue deposition of extracellular matrix (ECM) components, leading to scarring and impaired function across multiple organ systems. This complex process is mediated by a dynam...
Better Together: Interorganellar Communication in the Regulation of Proteostasis [0.03%]
携手同行：细胞器交流在蛋白质稳态调节中的作用
Andreas Kohler,Verena Kohler
Andreas Kohler
An extensive network of chaperones and folding factors is responsible for maintaining a functional proteome, which is the basis for cellular life. The underlying proteostatic mechanisms are not isolated within organelles, rather they are co...
Mitochondria, Peroxisomes and Beyond-How Dual Targeting Regulates Organelle Tethering [0.03%]
线粒体、过氧化物酶体等细胞器的双重定位及其锚定效应
Johannes Freitag,Thorsten Stehlik,Gert Bange
Johannes Freitag
Eukaryotic cells feature distinct membrane-enclosed organelles such as mitochondria and peroxisomes, each playing vital roles in cellular function and organization. These organelles are linked at membrane contact sites, facilitating interor...
Erratum to "Not so Rare: Diseases based on Mutant Proteins Controlling Endoplasmic Reticulum-Mitochondria Contact (MERC) Tethering" [0.03%]
关于“不那么罕见：基于突变蛋白质控制内质网-线粒体接触(MERC)连接的疾病”的勘误
[This corrects the article DOI: 10.1177/25152564241261228.]. © The Author(s) 2024.
Getting to Grips with the Oxysterol-Binding Protein Family - a Forty Year Perspective [0.03%]
抓OXSTEROL-结合蛋白家族的特征-四十年回顾
Vesa M Olkkonen,Elina Ikonen
Vesa M Olkkonen
This review discusses how research around the oxysterol-binding protein family has evolved. We briefly summarize how this protein family, designated OSBP-related (ORP) or OSBP-like (OSBPL) proteins, was discovered, how protein domains highl...
Recent Advances on Synaptotagmin-Like Mitochondrial-Lipid Binding Protein Domain Containing Lipid Transfer Proteins [0.03%]
近年线粒体脂质结合蛋白结构域脂质转移蛋白研究进展
Xuewen Hu,Yirui Cai,Wei-Ke Ji
Xuewen Hu
The Synaptotagmin-like mitochondrial-lipid binding protein (SMP) domain is found in a group of ER-resident lipid transfer proteins that are recruited to membrane contact sites (MCSs) by adaptors. Deciphering the molecular basis underlying t...
Protection of Membrane Contact Protein by the Methionine Sulfoxide Reductases [0.03%]
甲硫氨酸硫酸盐还原酶对膜结合蛋白的保护作用
Jung Mi Lim
Jung Mi Lim
In this News and Views, I discuss our recent publication that established how steroidogenic acute regulatory-related lipid transfer domain-3 (STARD3), a membrane contact protein situated at lysosomal membranes, plays a role in the detoxific...
Not So Rare: Diseases Based on Mutant Proteins Controlling Endoplasmic Reticulum-Mitochondria Contact (MERC) Tethering [0.03%]
不罕见的疾病：基于突变蛋白控制内质网-线粒体接触（MERC）栓系的疾病的罕见性分析
Tadashi Makio,Thomas Simmen
Tadashi Makio
Mitochondria-endoplasmic reticulum contacts (MERCs), also called endoplasmic reticulum (ER)-mitochondria contact sites (ERMCS), are the membrane domains, where these two organelles exchange lipids, Ca2+ ions, and reactive oxygen species. Th...
Spartin is a Lipid Transfer Protein That Facilitates Lipid Droplet Turnover [0.03%]
SPL是脂质转移蛋白，可促进脂滴周转
Yaoyang Zhong,Tim P Levine
Yaoyang Zhong
One means by which cells reutilize neutral lipids stored in lipid droplets is to degrade them by autophagy. This process involves spartin, mutations of which cause the rare inherited disorder Troyer syndrome (or spastic paraplegia-20, SPG20...
Contacting the gut: Mitochondria-associated Endoplasmic Reticulum Membranes in the Enteric Nervous System [0.03%]
肠道接触：肠神经系统中的线粒体相关内质网膜
Jenny Greig,Giada Delfino,Pascal Derkinderen et al.
Jenny Greig et al.
Changes in the connections between the endoplasmic reticulum (ER) and mitochondria, as well as alterations in mitochondria-associated ER membrane (MAM) signalling, have been documented in various neurodegenerative diseases affecting the bra...