Shuliang Chen,Melissa A Roberts,Chun-Yuan Chen et al.
Shuliang Chen et al.
Lipid transfer proteins mediate the exchange of lipids between closely apposed membranes at organelle contact sites and play key roles in lipid metabolism, membrane homeostasis, and cellular signaling. A recently discovered novel family of ...
Moving Lipids, by the Numbers [0.03%]
脂类运动知多少
Pascal F Egea
Pascal F Egea
Yongli Zhang,Jinghua Ge,Xin Bian et al.
Yongli Zhang et al.
Lipid transfer proteins (LTPs) transfer lipids between different organelles, and thus play key roles in lipid homeostasis and organelle dynamics. The lipid transfer often occurs at the membrane contact sites (MCS) where two membranes are he...
Inositol triphosphate signaling triggers lysosome biogenesis via calcium release from endoplasmic reticulum stores [0.03%]
肌醇三磷酸信号通过内质网钙释放诱导溶酶体生物合成
Mouhannad Malek,Volker Haucke
Mouhannad Malek
Lysosomes serve as cellular degradation and signaling centers that coordinate the turnover of macromolecules with cell metabolism. The adaptation of cellular lysosome content and activity via the induction of lysosome biogenesis is therefor...
Suzan Kors,Michael Schrader,Joseph L Costello
Suzan Kors
Peroxisomes and the ER are closely inter-connected organelles, which collaborate in the metabolism of lipids. In a recent research paper in the Journal of Cell Biology, we describe a novel mechanism by which peroxisome-ER membrane contact s...
Yotam David,Inês G Castro,Maya Schuldiner
Yotam David
Contact sites are areas of close apposition between two membranes that coordinate nonvesicular communication between organelles. Such interactions serve a wide range of cellular functions from regulating metabolic pathways to executing stre...
"VTT"-domain proteins VMP1 and TMEM41B function in lipid homeostasis globally and locally as ER scramblases [0.03%]
"VTT"结构域蛋白VMP1和TMEM41B作为内质网 scramble 酶参与全局和局部的脂质稳态调节
Karin M Reinisch,Xiao-Wei Chen,Thomas J Melia
Karin M Reinisch
Recent studies have identified the metazoan ER-resident proteins, TMEM41B and VMP1, and so structurally related VTT-domain proteins, as glycerolipid scramblases.
Remodelling of Nucleus-Vacuole Junctions During Metabolic and Proteostatic Stress [0.03%]
代谢和蛋白质稳态压力下的核质体连接重构
Verena Kohler,Sabrina Büttner
Verena Kohler
Cellular adaptation to stress and metabolic cues requires a coordinated response of different intracellular compartments, separated by semipermeable membranes. One way to facilitate interorganellar communication is via membrane contact site...
Lipid Droplet Contacts With Autophagosomes, Lysosomes, and Other Degradative Vesicles [0.03%]
脂滴与自噬体、溶酶体和其他降解小泡的相互作用
Kristina Drizyte-Miller,Micah B Schott,Mark A McNiven
Kristina Drizyte-Miller
Lipid droplets (LDs) are dynamic fat-storage organelles that interact readily with numerous cellular structures and organelles. A prominent LD contact site is with degradative vesicles such as autophagosomes, lysosomes, autolysosomes, and l...
What the VAP: The Expanded VAP Family of Proteins Interacting With FFAT and FFAT-Related Motifs for Interorganellar Contact [0.03%]
expanded VAP家族与含FFAT和类似FFAT基序的蛋白互作以介导细胞器接触
Jacques Neefjes,Birol Cabukusta
Jacques Neefjes
Membrane contact sites are formed by tether proteins that have the ability to bring two organellar membranes together. VAP proteins are a family of endoplasmic reticulum (ER)-resident tether proteins specialized in interacting with FFAT (tw...