Francesca Giordano,Chrisostomos Prodromou
Francesca Giordano
Vladimir Zhemkov,Jen Liou,Ilya Bezprozvanny
Vladimir Zhemkov
Recent studies indicated potential importance of membrane contact sites (MCS) between the endoplasmic reticulum (ER) and other cellular organelles. These MCS have unique protein and lipid composition and serve as hubs for inter-organelle co...
Yuchen Lei,Xin Wen,Daniel J Klionsky
Yuchen Lei
Vps13 is a large, conserved protein that transports lipids between membranes. Its localization at multiple organelle membranes and membrane contact sites suggests its important physiological roles. In addition, the high correlation of mutan...
A Tetrameric Assembly of Saposin A: Increasing Structural Diversity in Lipid Transfer Proteins [0.03%]
四聚体脂质转移蛋白糖脂寡糖酶结构多样性增加
Maria Shamin,Samantha J Spratley,Stephen C Graham et al.
Maria Shamin et al.
Saposins are lipid transfer proteins required for the degradation of sphingolipids in the lysosome. These small proteins bind lipids by transitioning from a closed, monomeric state to an open conformation exposing a hydrophobic surface that...
Autophagy of the ER requires actin assembly driven by the interaction of ER with endocytic pits [0.03%]
内质网自噬需要通过内质网与胞吞囊泡相互作用驱动的肌动蛋白聚合
Peter Novick,Dongmei Liu,Susan Ferro-Novick
Peter Novick
Autophagy of the cortical ER in budding yeast was unexpectedly found to require End3, a component of the endocytic machinery that promotes the assembly of actin at endocytic pits on the plasma membrane. The cortical ER transiently interacts...
ER membrane contact sites: key platforms for biogenesis of RNA-containing extracellular vesicles [0.03%]
内质网膜接触点：含RNA胞外囊泡生物发生的关键平台
Bahnisikha Barman,T Renee Dawson,Alissa M Weaver
Bahnisikha Barman
The mechanisms by which cytoplasmic cargoes such as RNAs are incorporated into extracellular vesicles (EVs) are poorly understood. In a recent article published in Developmental Cell, we describe a novel function of endoplasmic reticulum me...
The Hob proteins: Putative, novel lipid transfer proteins at ER-PM contact sites [0.03%]
Hob蛋白：内质网-质膜接触位点的潜在新型脂质转运蛋白
Sarah D Neuman,Amy T Cavanagh,Arash Bashirullah
Sarah D Neuman
Nonvesicular transfer of lipids at membrane contact sites (MCS) has recently emerged as a critical process for cellular function. Lipid transfer proteins (LTPs) mediate this unique transport mechanism, and although several LTPs are known, t...
Sequence Analysis and Structural Predictions of Lipid Transfer Bridges in the Repeating Beta Groove (RBG) Superfamily Reveal Past and Present Domain Variations Affecting Form, Function and Interactions of VPS13, ATG2, SHIP164, Hobbit and Tweek [0.03%]
重复的β沟(RBG)超家族中脂质转移桥的序列分析和结构预测揭示了影响VPS13、ATG2、SHIP164、Hobbit 和 Tweek 形状、功能及相互作用的过去与现在的结构域变化
Tim P Levine
Tim P Levine
Lipid transfer between organelles requires proteins that shield the hydrophobic portions of lipids as they cross the cytoplasm. In the last decade a new structural form of lipid transfer protein (LTP) has been found: long hydrophobic groove...
Nuclear Interactions: A Spotlight on Nuclear Mitochondrial Membrane Contact Sites [0.03%]
核相互作用：聚焦核-线粒体膜接触位点
Jana Ovciarikova,Shikha Shikha,Lilach Sheiner
Jana Ovciarikova
Membrane contact sites (MCS) are critical for cellular functions of eukaryotes, as they enable communication and exchange between organelles. Research over the last decade unravelled the function and composition of MCS between a variety of ...
Mitochondria from the Outside in: The Relationship Between Inter-Organelle Crosstalk and Mitochondrial Internal Organization [0.03%]
线粒体由外及内的认识：器官间对话与线粒体内部分化的关系
Jonathan R Friedman
Jonathan R Friedman
A fundamental role of membrane-bound organelles is the compartmentalization and organization of cellular processes. Mitochondria perform an immense number of metabolic chemical reactions and to efficiently regulate these, the organelle orga...