Longitudinal Monitoring of T cell Dynamics in Metastatic Breast Cancer via a Remote Diagnostic Implant [0.03%]
通过远程诊断植入物监测转移性乳腺癌中的T细胞动力学
Ian A Schrack,Rebecca S Pereles,Brian C Ross et al.
Ian A Schrack et al.
Metastatic triple negative breast cancer poses a significant health challenge due to rapid progression and limited treatment options. Immunotherapies targeting T cell responses against metastatic tumors depend on the presence of specific T ...
Engineered Immunologic Niche Monitors Checkpoint Blockade Response and Probes Mechanisms of Resistance [0.03%]
工程化免疫生态位监测检查点封锁反应并探究耐药机制
Ravi M Raghani,Russell R Urie,Jeffrey A Ma et al.
Ravi M Raghani et al.
Antibodies to programmed cell death protein1 (anti-PD-1) have become a promising immunotherapy for triple negative breast cancer (TNBC), blocking PD-L1 signaling from pro-tumor cells through T cell PD-1 receptor binding. Nevertheless, only ...
Metabolic inhibitor screening identifies dihydrofolate reductase as an inducer of the tumor immune escape mediator CD24 [0.03%]
代谢抑制剂筛选识别出二氢叶酸还原酶作为肿瘤免疫逃逸介质CD24的诱导物
Austin C Boese,Jung Seok Hwang,Isabelle Young et al.
Austin C Boese et al.
Immune checkpoint inhibitors have improved the clinical management of some cancer cases, yet patients still fail to respond to immunotherapy. Dysregulated metabolism is a common feature of many cancers, and metabolites are known to modulate...
Understanding Immunotherapy Terminology: An Analysis of Provider-Patient Conversations [0.03%]
解读免疫疗法术语：来自医务人员-患者对话的分析
Shannon Blee,Bari Rosenberg,Jeffrey M Switchenko et al.
Shannon Blee et al.
Background: Immunotherapy terminology is complex and can be difficult for patients to understand, threatening informed consent. The aims of this exploratory study are to determine whether patients understand immunotherapy...