Oral functional limitation and risk of frailty onset in older adults: a sex-stratified 4-Year cohort study with competing risk analysis [0.03%]
老年人口功能限制与脆弱高风险：一项为期四年的性别的队列研究及竞争性风险分析
Kyung-Yi Do,Chang Won Won,Miji Kim et al.
Kyung-Yi Do et al.
Background: Oral functional decline may contribute to frailty in older adults by affecting nutrition, physical performance, and psychosocial well-being. However, longitudinal evidence using rigorous analytic approaches, i...
Mesenchymal cell-derived extracellular vesicles ameliorate age-related deficits in working memory and in vivo MRI measures of white matter structure and function in rhesus monkeys [0.03%]
骨髓间充质细胞来源的外泌体改善了食蟹猴体内工作记忆和白质结构与功能年龄相关性缺陷
Evan C Mackie,Chia-Hsin Cheng,Maya N Alibrio et al.
Evan C Mackie et al.
Aging humans and non-human primates both exhibit a similar pattern of cognitive decline beginning in middle age that is characterized by progressive impairments in rule learning, executive function, and working and recognition memory-functi...
Intervertebral disc degeneration is accelerated by GH overexpression but attenuated by GH antagonism [0.03%]
生长激素过表达可加速椎间盘退变而生长激素拮抗则减轻椎间盘退变
Abhijit Sukul,Siqi Ren,Anna E Miller et al.
Abhijit Sukul et al.
Background: Intervertebral disc degeneration (IVDD) is a leading contributor to lower back pain, yet its underlying mechanisms remain poorly defined. While insulin-like growth factor 1 (IGF-1) has been implicated in disc ...
Prevalence and clinical implications of Rapid eye movement sleep behavior disorder in Alzheimer's disease and Lewy body dementia [0.03%]
阿尔茨海默病和路易体痴呆中快速眼动睡眠行为障碍的患病率及其临床意义
Jiaxin Yang,Wanting Xue,Huihui Zhang et al.
Jiaxin Yang et al.
Rapid eye movement sleep behavior disorder (RBD) is increasingly recognized as a significant clinical feature in neurodegenerative diseases like Alzheimer's disease (AD) and Lewy body dementia (LBD). This study investigates the prevalence a...
Multiparametric profiling of plasma cell-free nucleic acids in nonagenarians and centenarians highlights age-related differences associated with longevity [0.03%]
多重参数分析九旬和百岁老人血浆游离核酸谱型，揭示与长寿相关的年龄差异
Nicolas P Tessier,Lise M Hardy,Florence Mauger et al.
Nicolas P Tessier et al.
Plasma circulating cell-free nucleic acids (ccfNAs) have emerged as promising non-invasive biomarkers of aging. While age-associated changes have been reported, data in relation to extreme aging and longevity remain scarce. Here, we assesse...
Visual cortical responses in age-related hearing loss show evidence for compensatory neuroplasticity [0.03%]
年龄相关性听力损失的视觉皮层反应显示了补偿性的神经可塑性证据
Patricia V Aguiar,Michelle R Williams,Brandon T Paul
Patricia V Aguiar
Sensory loss is prevalent in older adults and is associated with changes to brain structure and function. In early life, the brain compensates for sensory loss by upregulating intact senses, such as in deafness where neural sensitivity for ...
Amanda L Lumsden,Anwar Mulugeta,Elina Hyppönen
Amanda L Lumsden
Sub-optimal metabolism is linked to dementia risk, yet metabolic traits rarely occur in isolation. Using data from 308,019 UK Biobank participants, we examined associations of six diverse metabolic subgroups (I-VI) - previously derived via ...
Plasma biomarkers of alzheimer's disease and related dementias are associated with cognitive change in community-dwelling older individuals in Australia and the US [0.03%]
澳大利亚和美国社区老年人阿尔茨海默病及相关痴呆症的血浆生物标志物与认知变化相关
Zimu Wu,Michelle M Mielke,Anne M Murray et al.
Zimu Wu et al.
Plasma biomarkers of Alzheimer's disease and related dementias (ADRD) are associated with the risk of dementia. However, the extent to which they could reflect cognitive ageing, and whether this is consistent across factors known to influen...
Longevity-driven hepatic transcriptional programs mediate resilience to diet-induced liver injury in Ames dwarf mice [0.03%]
长寿驱动的肝脏转录程序介导了Ames侏儒小鼠对饮食诱导的肝损伤的耐受性
Jaspreet Kaur Osan,Sharlene Rakoczy,Heidi L Pecoraro et al.
Jaspreet Kaur Osan et al.
The liver plays a central role in regulating systemic metabolism, and its function declines with age, contributing to increased susceptibility to metabolic diseases. Metabolic dysfunction-associated steatotic liver disease (MASLD), characte...
Cortical spreading depolarizations in stroke: Mechanisms, neuroprotective interventions, and monitoring techniques [0.03%]
脑卒中皮质扩散性去极化机制、神经保护干预及监测技术
Andrea Díaz-Pérez,Nerea Alvarez de Eulate,Eduard Masvidal-Codina et al.
Andrea Díaz-Pérez et al.
Cortical spreading depolarization (CSD) is a pathophysiological event critically implicated in ischemic stroke and other brain disorders. It consists of slowly propagating waves of massive neuronal and glial depolarization in cerebral gray ...