Understanding temporal changes in intrinsic capacity: analysis of domain-specific intrinsic capacity using SHARE data [0.03%]
利用SHARE数据理解内在能力的时变特征：特定领域内生型能力分析
Roy Tzemah-Shahar,Khalit Iktilat,Benjamin Seligman
Roy Tzemah-Shahar
Global population aging challenges acute, disease-centric healthcare models and highlights the need for functional markers of aging. The World Health Organization's intrinsic capacity (IC) framework, encompassing cognition, vitality, locomo...
Senescent cardiac cells promote thrombus formation and impair fibrinolysis [0.03%]
衰老的心脏细胞促进血栓形成并影响纤维蛋白溶解
Tal Shahar,Noa Ezra,Saray Chen et al.
Tal Shahar et al.
As a major contributor to cardiac diseases, thrombosis, a pathological process in which the formation of a blood clot restricts blood flow, is a leading cause of mortality worldwide. A central event in thrombosis involves thrombin-mediated ...
Genome-wide analysis of subcortical aging identifies a spatially structured pattern of genetic associations [0.03%]
全基因组分析发现皮质下老化具有遗传关联的结构分布模式
Nicholas J Kim,Ayati Mishra,Jeremy S Yu et al.
Nicholas J Kim et al.
Local brain age (LBA) is a spatially resolved biomarker of brain aging that captures regional deviations from chronological age, yet its genetic architecture in the subcortex remains unexplored. Here, we present the first genome-wide associ...
Heterogeneity in the association between APOE ε4 carrier status and dementia risk by modifiable and non-modifiable risk factors [0.03%]
APOE ε4携带状态与痴呆风险之间关联的异质性：可变因素和不变因素的影响
Mengrong Zhang,Frederick K Ho,Jill P Pell et al.
Mengrong Zhang et al.
Dementia is a major public health challenge, and Apolipoprotein E (APOE) ε4 is strongly associated with all-cause dementia, particularly Alzheimer's disease (AD). We aim to quantify the overall contribution of modifiable lifestyle, adiposi...
Mistakes matter, age doesn't: task outcome modulates implicit motor adaptation similarly in young and older adults [0.03%]
失误才重要，年龄不值钱——年轻和年老的成年人在隐性运动适应方面并无差异
Matheus Maia Pacheco,Pauline Hermans,Dante Mantini et al.
Matheus Maia Pacheco et al.
Despite several age-related processes impacting motor performance, older adults often retain the ability to implicitly adapt to sensory prediction errors. Here, we leverage the fact that implicit adaptation is not attenuated by aging to stu...
Oral LNAD+ rapidly elevates whole blood intracellular NAD and metabolic flux without elevating plasma NAD: evidence from a randomized controlled trial [0.03%]
一项随机对照实验的证据：口服LNAD+快速提高整个血液中细胞内NAD和代谢流量，而不升高血浆中的NAD水平
Sergey A Kornilov,Waylon J Hastings,Lynne Fahey McGrath et al.
Sergey A Kornilov et al.
Declines in nicotinamide adenine dinucleotide (NAD+) are linked to metabolic stress accompanying aging and disease. While precursor-based approaches elevate systemic NAD, their clinical translation can be constrained by biosynthetic bottlen...
Epigenetic aging biomarkers in dietary geroscience: feasibility, participant perceptions, and trial design considerations [0.03%]
饮食抗衰老科学中的表观遗传衰老生物标志物：可行性、受试者认知以及试验设计注意事项
Lindsay M Reynolds,Timothy D Howard,Carl D Langefeld et al.
Lindsay M Reynolds et al.
Targeting biological processes of aging is a central goal of geroscience; however, limited data exist regarding the feasibility of incorporating biological aging biomarkers into dietary intervention trials. We conducted a pilot feasibility ...
Statin therapy optimization in older adults: interim results of a randomized controlled trial of pharmacist-led pharmaceutical care [0.03%]
药师引领的药学关护下的他汀类药物治疗优化研究——随机对照试验中期结果报告
Anna Artner,Ágnes Szélvári,Ilona Oláh et al.
Anna Artner et al.
Statin optimization in older adults is increasingly relevant within the geroscience framework of cardiovascular ageing. This randomized controlled trial evaluated whether pharmacist-led pharmaceutical care improves lipid outcomes and statin...
Age-related differences in liver damage and inflammation after femoral osteotomy [0.03%]
股骨截骨术后年龄相关的肝损伤和炎症差异
Helen Rinderknecht,Rui Ding,Tong Wang et al.
Helen Rinderknecht et al.
Fractures of long bones such as the femur are a common and serious health concern in the elderly, triggering immune responses essential for healing but also affecting remote organs like the liver. With age, the risk of fractures and immune ...
Sensory impairment, epigenetic ageing, and later-life functional decline and mortality in older adults [0.03%]
感觉障碍、表观遗传衰老与老年人的后期功能衰退和死亡率之间的关系
Xiangwei Li,Chongyu Ding,Yaqian Xu et al.
Xiangwei Li et al.
Sensory impairment (SI) and accelerated epigenetic aging are both linked to later-life vulnerability, yet their joint value for risk stratification remains poorly understood. We investigated whether the co-occurrence of sensory deficits and...