Mild cognitive impairment and pre-frailty show distinct plasma multi-omic signatures: a cross-sectional study [0.03%]
轻度认知障碍和前衰弱表现出不同的血浆多组学标志物：横断面研究
Jelle C B C de Jong,Marjanne D van der Hoek,Koen W W Koopman et al.
Jelle C B C de Jong et al.
Frailty and cognitive impairments frequently co-occur in older adults. It remains unclear whether this overlap reflects shared underlying biological mechanisms or parallel but distinct disease pathways. We hypothesize that physical weakness...
Melitta Csepregi,Cecília Carreiro,Sara Świerkosz et al.
Melitta Csepregi et al.
Family dogs' human-analogue attachment to the owner has long been recognised; however, how this dog-owner attachment develops and changes with age remains an open question. We examined age-related variation and the effect of training experi...
Matthew Bratton,Audrey Ulfers,Gregory Laborde et al.
Matthew Bratton et al.
Osteoporosis, characterized by low bone mineral density (BMD) and increased fracture risk, is common yet underdiagnosed in older adults. Medications such as corticosteroids, levothyroxine, and antiepileptic drugs are well-documented contrib...
Examination of DNAm PhenoAge as an epigenetic biomarker for perioperative risk in adult spinal deformity surgeries [0.03%]
检测DNAm PhenoAge作为成人脊柱畸形手术围术期风险的表观遗传生物标志物的能力
Michael P Kelly,Jeffrey Hills,Justin S Smith et al.
Michael P Kelly et al.
Epigenetic changes, such as DNA methylation (DNAm), offer a measure of biological age distinct from chronological age. DNAm PhenoAge is one such biomarker that is more strongly related to morbidity, mortality, and physical function than chr...
Multicenter Study
GeroScience. 2026 Oct;48(5):6289-6298. DOI:10.1007/s11357-026-02481-8 2026
Hyaluronan deficiency disrupts endothelial glycocalyx integrity and contributes to age-related arterial dysfunction [0.03%]
透明质酸缺乏破坏内皮糖萼完整性并导致与年龄相关的动脉功能障碍
Jisok Lim,John Kim,Venkateswara R Gogulamudi et al.
Jisok Lim et al.
Aging is accompanied by arterial dysfunction, defined by impaired endothelial function and increased large artery stiffness, yet the contribution of the endothelial glycocalyx (eGC) and its constituent, hyaluronan (HA), to this process rema...
BRAIN-DISC: a novel analytical approach integrating data-driven brain pattern discovery with cohort studies for evaluating findings in brain modulation interventions [0.03%]
一种新颖的分析方法：结合数据驱动脑模式发现与队列研究评估脑调控干预结果
Meishan Ai,Adam Turnbull,Kanhao Zhao et al.
Meishan Ai et al.
Brain modulation interventions (BMIs) targeting cognitive and neuropsychiatric symptoms have shown substantial heterogeneity in response, limiting their clinical utility. Resting-state functional connectivity (rsFC) may capture BMI-induced ...
Endothelial IGF-1/IGF-1R signaling supports young-blood-induced restoration of blood-brain barrier integrity and microvascular architecture in aged mice: evidence from the heterochronic parabiosis model [0.03%]
内皮IGF-1/IGF-1R信号传导可支持年轻血液诱导的小鼠血脑屏障的完整性以及血管结构的恢复：异时性半联体模型的证据
Rafal Gulej,Rebeka Kristof,Roland Patai et al.
Rafal Gulej et al.
Aging is associated with blood-brain barrier (BBB) breakdown and microvascular rarefaction, key contributors to cerebral neuroinflammation, hypoperfusion, and vascular cognitive impairment and dementia (VCID). Exposure to a young systemic m...
The impact of cumulative obesity and genetic susceptibility on biological aging in Chinese older adults [0.03%]
中国老年人群肥胖与遗传易感性对生物学衰老的影响研究
Jiening Yu,Liming Zhang,Zhenqing Yang et al.
Jiening Yu et al.
The detrimental impacts of cumulative obesity exposures and their interactions with genetics on biological aging remain poorly understood. We included 687 older adults (median age: 79.6 years) from the Rugao Longitudinal Ageing Study (RLAS)...
CT-based prediction of hematoma expansion and adverse outcomes after intracerebral hemorrhage: evidence appraisal, artificial intelligence translation, and GeroScience perspectives [0.03%]
基于CT的脑内出血后血肿扩大和不良结局的预测：证据评估、人工智能翻译和衰老科学视角
Shuai Liu,Weihao Fu,Xiaoying Tang et al.
Shuai Liu et al.
Spontaneous intracerebral hemorrhage (ICH) is a highly lethal and disabling form of stroke, in which hematoma expansion (HE) is a major and potentially modifiable determinant of early neurological deterioration and poor functional outcome. ...
Dysregulated lncRNAs are associated with the progressive arterial phenotype in Hutchinson-Gilford Progeria Syndrome [0.03%]
与Hutchinson-Gilford早老症动脉表型进展相关的失调长链非编码RNA
Lara G Merino,Santhilal Subhash,Daniel Whisenant et al.
Lara G Merino et al.
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare premature aging disorder caused by de novo LMNA mutations. Patients develop severe systemic symptoms limiting life quality and ultimately causing death from cardiovascular events. Despit...