Ovarian somatic tissue rejuvenates circulating apolipoproteins and promotes cognitive health in postreproductive female mice [0.03%]
卵巢体细胞使小鼠产后循环中的载脂蛋白返老还童并促进认知健康
Nathan D McCoy,Steven P Gawrys,Samuel G Mackintosh et al.
Nathan D McCoy et al.
Women experience more pronounced lipidomic changes with aging than men, which may contribute to the higher rates of Alzheimer's disease seen in postmenopausal women. Our earlier findings showed that transplantation of young ovarian somatic ...
Elevated mtDNA copy number in older adults is linked to methylation of mitochondrial and nuclear regulatory regions [0.03%]
老年人线粒体DNA拷贝数升高的现象与线粒体和核调控区域甲基化有关
Hongbo Chi,Hongying Shu,Yingmei Yang et al.
Hongbo Chi et al.
Growing evidence shows that epigenetic modification and mitochondrial dysfunction are hallmarks of aging and are associated with the development of a wide range of age-related diseases. Mitochondrial biogenesis, which is marked by mitochond...
Deep neural networks and genome-wide associations reveal the polygenic architecture of local brain aging [0.03%]
深度神经网络和全基因组关联揭示局部脑衰老的多基因结构
Nicholas J Kim,Ayati Mishra,Nahian F Chowdhury et al.
Nicholas J Kim et al.
Local brain age (LBA) is a regional metric of brain aging that offers a spatially resolved alternative to global brain age, but whose genetic basis is unexplored. This study reports the first genome-wide association study of cortical LBA, a...
Malnutrition as an independent risk factor for incident delirium in cohort of older adults receiving domiciliary care services [0.03%]
营养不良是接受居家护理服务的老年人发生谵妄的独立危险因素：前瞻性队列研究
Benedicte Huseby Bøhn,Maria Krogseth,Nina Jøranson et al.
Benedicte Huseby Bøhn et al.
Background: Malnutrition and frailty frequently affect older adults receiving domiciliary care services, increasing their vulnerability to adverse events such as delirium. Despite this, the role of malnutrition as a risk ...
Your brain doesn't look a day past 70! Cross-sectional associations with brain-predicted age in the cognitively-intact oldest-old [0.03%]
你的大脑看起来不超过70岁！认知正常的长寿老人中基于大脑预测年龄的横断面研究结果
Mark K Britton,Hannah Hoogerwoerd,Joshua Juhasz et al.
Mark K Britton et al.
The cognitively-intact oldest-old (85 +) may be the most-resilient members of their birth cohort; due to survivorship effects (e.g., depletion of susceptibles), risk factors associated with brain aging biomarkers in younger samples may not ...
A multi-omics analysis of human fibroblasts overexpressing an Alu transposon reveals widespread disruptions in aging-associated pathways [0.03%]
人成纤维细胞过表达Alu转座子的多组学分析揭示了与衰老相关途径的广泛破坏
Juan I Bravo,Eyael Tewelde,Christina D King et al.
Juan I Bravo et al.
During aging and cellular senescence, repetitive elements are frequently transcriptionally derepressed across species and cell types. Among these, the most abundant repeats by copy number in the human genome are Alu retrotransposons. Though...
Healthy diet and slower biological aging as protective factors against microvascular complications in type 2 diabetes [0.03%]
健康饮食和延缓生物学老化对2型糖尿病微血管并发症的保护作用
Han Zhou,Shuai Ben,Qian Ma et al.
Han Zhou et al.
This study aimed to evaluate the independent and joint effects of adherence to healthy dietary patterns and slower biological aging on the incidence of diabetic microvascular complications in individuals with type 2 diabetes mellitus (T2DM)...
Cognitive training effects are shaped more by individual brain dynamics than age-evidence from younger and older women [0.03%]
认知训练效果由个体大脑动力学决定的机制强于年龄的影响-来自年轻和年老女性的证据
Zsófia Anna Gaál,Petia Kojouharova,Boglárka Nagy et al.
Zsófia Anna Gaál et al.
Given the well-established structural and functional changes in the aging brain, it is widely assumed that cognitive aging is primarily driven by robust group-level differences between young and older adults. However, our individual-level E...
Effect of fasting-mimicking diet on markers of autophagy and metabolic health in human subjects [0.03%]
断食模拟饮食对人类受试者自噬标志物和代谢健康的影响
Sara E Espinoza,Sue Park,Gavin Connolly et al.
Sara E Espinoza et al.
We conducted a pilot randomized clinical trial to examine the effects of the fasting-mimicking diet (FMD) on autophagic flux and metabolic health markers in healthy humans. Thirty healthy participants were randomized to two oral formulation...
Age-related change in skeletal muscle strength, size, and adiposity over 18 years in Caribbean men [0.03%]
海地男性骨骼肌力量、体积及脂肪含量18年的变化趋势
Lauren S Roe,Ryan K Cvejkus,Victor W Wheeler et al.
Lauren S Roe et al.
Declines in muscle strength outpace declines in muscle mass with age, so factors like muscle adiposity (i.e., myosteatosis) may contribute to strength loss. We describe intermuscular adipose tissue (IMAT) and grip strength over 18 years amo...