Adults up to 80 years old maintain effective movement planning when facing complex body dynamics [0.03%]
成年人在面对复杂的身体动力学时仍能保持有效的运动规划能力（直到80岁）
Anouck Matthijs,Anda de Witte,Dante Mantini et al.
Anouck Matthijs et al.
Aging significantly impacts motor performance, especially in multi-joint movement tasks where the nervous system needs to adequately coordinate mechanical interactions between joints. Effective coordination of multiple joints relies on inta...
Engagement in more light physical activity and less sedentary time does not protect against age-related declines in cerebrovascular reactivity in healthy older adults [0.03%]
在健康老年人群中，更多的轻体力活动和较少的久坐时间不能防止脑血管反应性随着年龄的增长而下降
Molly K Courish,Abigail V Wickens,Said Mekary et al.
Molly K Courish et al.
Decreased resting cerebral blood flow and cerebrovascular reactivity (CVR) are important age-related factors associated with an increased risk of stroke or dementia. However, these declines may be exaggerated by a sedentary lifestyle or blu...
Blood-based biomarkers of Alzheimer's disease and olfactory decline over 15 years in older adults [0.03%]
老年人阿尔茨海默病和嗅觉减退的血基生物标志物十五年的变化规律
Ingrid Ekström,Davide Liborio Vetrano,Martina Valletta et al.
Ingrid Ekström et al.
Olfactory impairment is common in older age and is a known early feature of several dementia diseases. Blood-based biomarkers of Alzheimer's disease (AD) now offer a scalable method for detecting pathophysiological mechanisms related to olf...
Zane Koch,Jessica L Graves,Steve Annan et al.
Zane Koch et al.
Aging is a complex biological process characterized by molecular changes across multiple biological scales. While these alterations have been extensively studied in humans and rodents, the molecular changes associated with aging in dogs rem...
Phuong-Anh Dinh,HyeRim Han,Seungsoo Kim et al.
Phuong-Anh Dinh et al.
The growing epidemiological burden of multimorbidity among older adults underscores an urgent need to develop interventions that can address multiple age-related diseases (ARDs) at once. Yet, the biological mechanisms driving their co-occur...
Sensorimotor function as an early marker of cognitive decline and alzheimer's biomarker burden [0.03%]
感觉运动功能作为认知衰退和阿尔茨海默病生物标志物负担的早期标志
Semere Bekena,Ramkrishna K Singh,Yiqi Zhu et al.
Semere Bekena et al.
Early identification of markers of cognitive decline in cognitively normal older adults is essential for dementia prevention strategies. Sensorimotor measures, such as gait speed, grip strength, and reaction time, may provide sensitive indi...
Smartphone self-testing of hand and speech motor functions: a study of reliability and usability in older adults [0.03%]
智能手机的手部和言语功能自测：老年人可靠性和使用性的研究
Renjie Li,Kaylee Rudd,Eddy Roccati et al.
Renjie Li et al.
Scalable remote-monitoring tools of motor function are vital for early detection and tracking of neurodegenerative diseases. This study evaluated the reliability and usability of TapTalk, a 2-min validated smartphone-based self-assessment o...
Effectiveness of acetylcholinesterase inhibitors and memantine in patients affected by severe dementia [0.03%]
胆碱酯酶抑制剂和美金刚在重度痴呆患者中的疗效分析
Giovanni Zuliani,Gloria Brombo,Tommaso Romagnoli et al.
Giovanni Zuliani et al.
The efficacy of acetylcholinesterase inhibitors (AChEI) and memantine (ME) in severe dementia remains uncertain, and real world data are limited. We evaluated the progression of cognitive decline and mortality rates in a cohort of outpatien...
Discrimination of normal from slow-aging mice by plasma metabolomic and proteomic features [0.03%]
基于血浆代谢组和蛋白质组特征鉴别正常小鼠与长寿小鼠
Bretton Badenoch,Oliver Fiehn,Noa Rappaport et al.
Bretton Badenoch et al.
Tests that can predict whether a drug is likely to extend mouse lifespan could speed up the search for anti-aging drugs. We have applied a machine learning algorithm, XGBoost regression, to seek sets of plasma metabolites (n = 12,000) and p...
Western Hunter-Gatherer genetic ancestry contributes to human longevity in the Italian population [0.03%]
西方狩猎采集者的遗传祖先对意大利人口的长寿有贡献
Stefania Sarno,Vincenzo Iannuzzi,Marco Sazzini et al.
Stefania Sarno et al.
The genetics of human longevity has been primarily studied using classical methods developed in genome-wide association studies. With the recent advances in paleogenomics, it is now possible to investigate to what extent ancient population ...