A novel approach to quantifying individual's biological aging using Korea's national health screening program toward precision public health [0.03%]
利用韩国国家健康筛查项目量化个体生物衰老的新方法以实现精准公共卫生管理
Jinho Yoo,Junguk Hur,Jintae Yoo et al.
Jinho Yoo et al.
Accurate prediction of biological age can inform public health measures to extend healthy lifespans and reduce chronic conditions. Multiple theoretical models and methods have been developed; however, their applicability and accuracy are st...
Extreme-aged patients (≥ 85 years) experience similar outcomes as younger geriatric patients following chronic subdural hematoma evacuation: a matched cohort study [0.03%]
极高龄患者(≥85岁)在慢性硬膜下血肿清除术后与相对年轻的老年人有相似的预后：一项配对队列研究
Peyton L Nisson,John J Francis,Michelot Michel et al.
Peyton L Nisson et al.
Subdural hematoma (SDH) evacuation represents one of the most frequently performed neurosurgical procedures. Several reports cite a rise in both the age and number of patient's requiring treatment, due in part to an aging population and exp...
Surgical management of spinal pathologies in the octogenarian: a narrative review [0.03%]
八旬老人脊柱疾病的手术治疗：循证综述
Alexander R Evans,Joshua Bakhsheshian,Christopher S Graffeo et al.
Alexander R Evans et al.
Optimal management paradigms of spinal pathologies in the octogenarian population are controversial given the higher incidence of comorbidities with concern for poor prognosis and fear of increased complications associated with surgical man...
Correction to: The CEPH aging cohort and biobank: a valuable collection of biological samples from exceptionally long‑lived French individuals and their offspring for longevity studies [0.03%]
校正：来自长寿的法国个体及其后代的CEPH老龄化队列和生物样本库：用于长寿研究的宝贵生物样品集合
Alexandre How-Kit,Mourad Sahbatou,Lise M Hardy et al.
Alexandre How-Kit et al.
Published Erratum
GeroScience. 2024 Jun;46(3):3503-3505. DOI:10.1007/s11357-024-01085-4 2024
Purpose in life and slow walking speed: cross-sectional and longitudinal associations [0.03%]
生活目标与缓慢行走速度：横断面研究和纵向研究的关联
Angelina R Sutin,Sabrina Cajuste,Yannick Stephan et al.
Angelina R Sutin et al.
The present research examines the association between purpose in life - a component of well-being defined as the feeling that one's life is goal-oriented and has direction - and slow walking speed and the risk of developing slow walking spe...
Meta-Analysis
GeroScience. 2024 Jun;46(3):3377-3386. DOI:10.1007/s11357-024-01073-8 2024
Aging induces changes in cancer formation and microbial content in a murine model of bladder cancer [0.03%]
老龄化导致小鼠膀胱癌模型中的癌症形成和微生物含量发生改变
Benjamin L Woolbright,Hao Xuan,Ishfaq Ahmed et al.
Benjamin L Woolbright et al.
Bladder cancer (BCa) incidence is tightly linked to aging. Older patients with BCa present with higher grade tumors and have worse outcomes on Bacillus-Calmette-Guerin (BCG) immunotherapy. Aging is also known to result in changes in the gut...
Mitochondrial complex I inhibition triggers NAD+-independent glucose oxidation via successive NADPH formation, "futile" fatty acid cycling, and FADH2 oxidation [0.03%]
线粒体复合物I的抑制通过连续生成NADPH、“无效”的脂肪酸循环及FADH2氧化来触发NAD+非依赖性葡萄糖氧化过程
Roman Abrosimov,Marius W Baeken,Samuel Hauf et al.
Roman Abrosimov et al.
Inhibition of mitochondrial complex I (NADH dehydrogenase) is the primary mechanism of the antidiabetic drug metformin and various unrelated natural toxins. Complex I inhibition can also be induced by antidiabetic PPAR agonists, and it is e...
The impact of a tDCS and cognitive training intervention on task-based functional connectivity [0.03%]
经颅直流电刺激和认知训练干预对任务基础上的功能连接的影响
Jessica N Kraft,Aprinda Indahlastari,Emanuel M Boutzoukas et al.
Jessica N Kraft et al.
Declines in several cognitive domains, most notably processing speed, occur in non-pathological aging. Given the exponential growth of the older adult population, declines in cognition serve as a significant public health issue that must be...
The plasma metabolome is associated with preservation of physiological function following lifelong aerobic exercise in mice [0.03%]
终生有氧运动的小鼠的生理功能得以保持与其等离子体代谢组有关
Kevin O Murray,Grace S Maurer,Rachel A Gioscia-Ryan et al.
Kevin O Murray et al.
Declines in physiological function with aging are strongly linked to age-related diseases. Lifelong voluntary aerobic exercise (LVAE) preserves physiological function with aging, possibly by increasing cellular quality control processes, bu...
Jelle C B C de Jong,Martien P M Caspers,Nicole Worms et al.
Jelle C B C de Jong et al.
Muscle-aging drives sarcopenia and is a major public health issue. Mice are frequently used as a model for human muscle-aging, however, research investigating their translational value is limited. In addition, mechanisms underlying muscle-a...