Angiotensin II, miR-34a, and AGTRAP crosstalk in arterial smooth muscle cells [0.03%]
血管紧张素II、miR-34a和AGTRAP在动脉平滑肌细胞中的相互作用
Maria Cristina Florio,Sara Sileno,Liqun Jiang et al.
Maria Cristina Florio et al.
Arterial aging is associated with enhanced angiotensin II (Ang II) signaling via Ang II type 1 receptor (AT1R) and with microRNA-34a (miR-34a) increased expression. AT1R-associated protein (ATRAP/Agtrap) binds to AT1R, promotes its internal...
Distinct patterns of endothelial response to endotoxin in aged mice as compared to young mice [0.03%]
与年轻小鼠相比，内毒素诱导的年老小鼠内皮细胞应答的独特模式
Joanna Suraj-Prażmowska,Magdalena Sternak,Anna Kurpińska et al.
Joanna Suraj-Prażmowska et al.
Aging exacerbates organ injury in endotoxemia, but it is not clear whether endotoxemia is associated with a specific, age-related profile of the endothelial response. Therefore, the aim of the study was to assess the pattern of endothelial ...
Workplace health promotion for healthy aging: a randomized controlled trial within the Semmelweis-EUniWell Workplace Health Promotion Model Program comparing email-based and face-to-face motivational interviewing to increase step count [0.03%]
职场健康促进与健康老龄化：塞梅尔维斯-Euniwell 职场健康促进模型方案内的随机对照试验，比较基于电子邮件和面对面的动机访谈以增加步数的效果
Wei Yi Hung,Dorottya Árva,Noémi Mózes et al.
Wei Yi Hung et al.
With the aging population in Europe, particularly Hungary, unhealthy aging is emerging as a growing public health challenge. Physical inactivity is a modifiable risk factor for age-related diseases and remains highly prevalent. Increasing d...
GDF-15 plasma levels are elevated in mobility-limited older adults with frailty and sarcopenia-results from the BIOFRAIL study [0.03%]
老年虚弱和肌肉减少症患者的GDF-15血浆水平升高——来自BIOFRAIL研究的结果
Pernille Hansen,Hanne Nygaard,Louis Praeger-Jahnsen et al.
Pernille Hansen et al.
Growth differentiation factor 15 (GDF-15) has been proposed as a potential biomarker for the geriatric syndromes of frailty and sarcopenia. This study investigated plasma GDF-15 as a biomarker associated with sarcopenia and frailty in a coh...
Necroptosis induced by MLKL overexpression in liver triggers cellular senescence and leads to chronic inflammation and fibrosis [0.03%]
MLKL过表达诱导的肝细胞坏死性凋亡引发衰老并导致慢性炎症和纤维化
Ramasamy Selvarani,Sunho Lee,Mani Saminathan et al.
Ramasamy Selvarani et al.
Cellular senescence and necroptosis are two cell fates, which trigger an inflammatory response and increase with age, that have been proposed to play a role in inflammaging. In this study, we performed the first study to directly test the p...
A ketogenic diet improves memory in females in the APOE4 mouse model of Alzheimer's disease [0.03%]
生酮饮食能改善载脂蛋白ε4基因型小鼠阿尔茨海默病模型中的女性记忆力
Jacopo Di Lucente,Jennifer M Rutkowsky,Alfredo Errico Provenzano et al.
Jacopo Di Lucente et al.
The ε4 allele of apolipoprotein E (APOE4) is the strongest genetic risk factor for Alzheimer's disease (AD), increasing AD risk about fourfold in ~ 34 million American and ~ 75 million European females. APOE4 carriers exhibit cerebral meta...
Benxamin Varela-López,Santiago Galdo-Álvarez,Alba Felpete et al.
Benxamin Varela-López et al.
Gait performance depends on numerous aspects of brain functioning that are also relevant to key cognitive processes throughout the lifespan. The Timed Up and Go (TUG) test has been shown to be a reliable tool for assessing age-related mobil...
Colorectal cancer screening, incidence, and mortality among aging veterans in the U.S. Department of Veterans Affairs healthcare system by housing status [0.03%]
美国退伍军人事务部医疗体系中按住房状况划分的老年退伍军人的结直肠癌筛查、发病率和死亡率
Hind A Beydoun,Shilpa S Murthy,Caroline G Falker et al.
Hind A Beydoun et al.
The objectives of this study are to examine colorectal cancer (CRC) screening, incidence, and mortality among veterans 45 to 75 years who are enrolled in the U.S. Department of Veterans Affairs (VA) healthcare system by housing instability ...
Effects of aging on transmission from Ia afferents to α-motoneurons and presynaptic mechanisms across muscle lengths and contraction types [0.03%]
老化对Ia传入到α-运动神经元的传递及不同肌长和收缩类型下的神经肌肉接头突触前机制的影响
Yohan Betus,Julian Colard,Marc Jubeau et al.
Yohan Betus et al.
Presynaptic inhibition of Ia afferents, particularly via primary afferent depolarization (PAD), plays a crucial role in modulating transmission from Ia afferents to α-motoneurons according to task demands. In young adults, PAD is enhanced ...
Nicotinamide riboside supplementation restores microglial health and improves cognition in aged male mice [0.03%]
烟酰胺核糖增补恢复老年小鼠的小胶质细胞健康和认知功能
Ramkumar Thiyagarajan,Rupadevi Muthaiah,Bhavana Sreevelu et al.
Ramkumar Thiyagarajan et al.
Cognitive impairment affects 1 in 6 individuals over 60, with over 75 million projected by 2030. Age-related changes in microglial function and declining nicotinamide adenine dinucleotide (NAD+) levels may contribute to cognitive decline. A...