Mechanism of Glycitein in the Treatment of Colon Cancer Based on Network Pharmacology and Molecular Docking [0.03%]
基于网络药理学和分子对接的大豆异黄酮甘察汀治疗结肠癌的机制研究
Tao Xiang,Weibiao Jin
Tao Xiang
Introduction: The prevalence of colon cancer remains high across the world. The early diagnosis of colon cancer is challenging. Moreover, patients with colon cancer frequently suffer from poor prognoses. ...
The rs9939609 Variant in FTO Increases the Risk of Hypercholesterolemia in Metabolically Healthy Subjects with Excess Weight [0.03%]
FTO基因rs9939609多态性通过增加代谢健康型超重个体的高胆固醇血症风险而影响体重相关心血管疾病发病风险的研究
Erika Sierra-Ruelas,Wendy Campos-Pérez,Nathaly Torres-Castillo et al.
Erika Sierra-Ruelas et al.
Introduction: The fat mass and obesity-associated gene (FTO) is largely/primarily expressed in the hypothalamus. It plays a role in energy balance, regulation of food intake, and adipogenesis. According to metabolic pheno...
Quantile-Specific Heritability of Mean Platelet Volume, Leukocyte Count, and Other Blood Cell Phenotypes [0.03%]
血小板平均体积、白细胞计数和其他血液细胞表型的分位数特异性遗传率
Paul T Williams
Paul T Williams
Introduction: "Quantile-dependent expressivity" occurs when the effect size of a genetic variant depends upon whether the phenotype (e.g., mean platelet volume, MPV) is high or low relative to its distribution. ...
Influences of the Interactions of Genetic Variations of Seven Core Circadian Clock Genes with Lifestyle Factors on Metabolic Parameters [0.03%]
七种核心生物钟基因多态性与生活习惯的交互作用对代谢参数的影响研究
Kimiko Yamakawa-Kobayashi,Sayaka Ishikawa,Nagi Miyake et al.
Kimiko Yamakawa-Kobayashi et al.
Introduction: In mammals, circadian rhythms regulate many behavioral and physiological processes. Genetic and epidemiological studies have shown that dysregulation of the circadian rhythm induces chronic metabolic disease...
Investigation of the Association between High Arachidonic Acid Synthesis and Colorectal Polyp Incidence within a Generally Healthy UK Population: A Mendelian Randomization Approach [0.03%]
在一般健康的英国人群中调查花生四烯酸合成过高与结直肠息肉发病率之间关联的孟德尔随机化研究
Rachel Moon,J Bernadette Moore,Mark A Hull et al.
Rachel Moon et al.
Background: Arachidonic acid (ARA) is associated with colorectal cancer (CRC), a major public health concern. However, it is uncertain if ARA contributes to the development of colorectal polyps which are pre-malignant pre...
Smoking-Interaction Loci Affect Obesity Traits: A Gene-Smoking Stratified Meta-Analysis of 545,131 Europeans [0.03%]
吸烟基因位点影响肥胖表型：欧洲人中545131人的基因-吸烟分层荟萃分析
Won-Jun Lee,Ji Eun Lim,Ji-One Kang et al.
Won-Jun Lee et al.
Introduction: Although many studies have investigated the association between smoking and obesity, very few have analyzed how obesity traits are affected by interactions between genetic factors and smoking. Here, we aimed...
Meta-Analysis
Lifestyle genomics. 2022;15(3):87-97. DOI:10.1159/000525749 2022
Upregulated miR-146a Expression in Peripheral Blood Relates to Th17 and Treg Imbalance in Elder Rheumatoid Arthritis Patients [0.03%]
外周血miR-146a表达上调与老年类风湿关节炎患者Th17/Treg失衡有关
Menglan Liu,Tianli Ren,Zhi Lin et al.
Menglan Liu et al.
Background: The expression level of microRNA-146a (miR-146a) increased in peripheral blood and synovialis tissue of rheumatoid arthritis (RA) patient, and it may play an important role in the pathological process of RA. W...
Understanding Gene-Lifestyle Interaction in Obesity: The Role of Mediation versus Moderation [0.03%]
理解肥胖症中基因-生活方式相互作用：中介与调节的作用
Louis Pérusse,Raphaëlle Jacob,Vicky Drapeau et al.
Louis Pérusse et al.
Background: Obesity results from complex interactions between genetic susceptibility to weight gain and poor eating and lifestyle behaviors. The approach that has been traditionally used in genetics to investigate gene-en...
Dairy Product Intake Modifies MicroRNA Expression among Individuals with Hyperinsulinemia: A Post-Intervention Cross-Sectional Study [0.03%]
乳制品摄入量调节高胰岛素血症患者体内微小核糖核酸表达：一项横断面研究
Leila Khorraminezhad,Iwona Rudkowska
Leila Khorraminezhad
Introduction: MicroRNA (miRNA) profiles have been shown to change after intake of dairy products. Dysregulation of miRNA is associated with the changes in the level of glycemic parameters. The objectives are: (1) to inves...
Randomized Controlled Trial
Lifestyle genomics. 2022;15(3):77-86. DOI:10.1159/000523809 2022
Efficacy of Probiotic, Chlorhexidine, and Sodium Fluoride Mouthrinses on Mutans Streptococci in 8- to 12-Year-Old Children: A Crossover Randomized Trial [0.03%]
儿童口腔益生菌、氯己定和氟化钠含漱液对变形链球菌抑制作用的交叉口述临床试验
Krutika Y Gedam,Amar N Katre
Krutika Y Gedam
Introduction: The oral cavity is home to a diverse and distinct microbiome. While the role of oral bacteria in cariogenic and other dental diseases is irrefutable, their beneficial effects in the form of probiotics (PB) h...
Randomized Controlled Trial
Lifestyle genomics. 2022;15(1):35-44. DOI:10.1159/000519916 2022