Understanding Gene-Lifestyle Interaction in Obesity: The Role of Mediation versus Moderation [0.03%]
理解肥胖症中基因-生活方式相互作用：中介与调节的作用
Louis Pérusse,Raphaëlle Jacob,Vicky Drapeau et al.
Louis Pérusse et al.
Background: Obesity results from complex interactions between genetic susceptibility to weight gain and poor eating and lifestyle behaviors. The approach that has been traditionally used in genetics to investigate gene-en...
Dairy Product Intake Modifies MicroRNA Expression among Individuals with Hyperinsulinemia: A Post-Intervention Cross-Sectional Study [0.03%]
乳制品摄入量调节高胰岛素血症患者体内微小核糖核酸表达：一项横断面研究
Leila Khorraminezhad,Iwona Rudkowska
Leila Khorraminezhad
Introduction: MicroRNA (miRNA) profiles have been shown to change after intake of dairy products. Dysregulation of miRNA is associated with the changes in the level of glycemic parameters. The objectives are: (1) to inves...
Randomized Controlled Trial
Lifestyle genomics. 2022;15(3):77-86. DOI:10.1159/000523809 2022
Efficacy of Probiotic, Chlorhexidine, and Sodium Fluoride Mouthrinses on Mutans Streptococci in 8- to 12-Year-Old Children: A Crossover Randomized Trial [0.03%]
儿童口腔益生菌、氯己定和氟化钠含漱液对变形链球菌抑制作用的交叉口述临床试验
Krutika Y Gedam,Amar N Katre
Krutika Y Gedam
Introduction: The oral cavity is home to a diverse and distinct microbiome. While the role of oral bacteria in cariogenic and other dental diseases is irrefutable, their beneficial effects in the form of probiotics (PB) h...
Randomized Controlled Trial
Lifestyle genomics. 2022;15(1):35-44. DOI:10.1159/000519916 2022
Association of Age-Related Cataract Risk with High Polygenetic Risk Scores Involved in Galactose-Related Metabolism and Dietary Interactions [0.03%]
与半乳糖相关代谢和饮食相互作用的多基因风险评分与年龄相关白内障发病风险关联的研究
Donghyun Jee,Suna Kang,Sunmin Park
Donghyun Jee
Introduction: Cataracts are associated with the accumulation of galactose and galactitol in the lens. We determined the polygenetic risk scores for the best model (PRSBM) associated with age-related cataract (ARC) risk an...
APOE Genotypes, Lipid Profiles, and Associated Clinical Markers in a Finnish Population with Cardiovascular Disease Risk Factors [0.03%]
芬兰心血管病危险因素人群的载脂蛋白E基因型、血脂特点及临床指标分布
Heidi Leskinen,Maaria Tringham,Heli Karjalainen et al.
Heidi Leskinen et al.
Introduction: The APOE ε4 allele predisposes to high cholesterol and increases the risk for lifestyle-related diseases such as Alzheimer's disease and cardiovascular diseases (CVDs). The aim of this study was to analyse ...
Quantile-Dependent Heritability of Glucose, Insulin, Proinsulin, Insulin Resistance, and Glycated Hemoglobin [0.03%]
葡萄糖、胰岛素、前胰岛素、胰岛素抵抗和糖化血红蛋白的分位数相关遗传性
Paul T Williams
Paul T Williams
Background: "Quantile-dependent expressivity" is a dependence of genetic effects on whether the phenotype (e.g., insulin resistance) is high or low relative to its distribution. ...
Marcia LeVatte,Ammar Hassanzadeh Keshteli,Parvin Zarei et al.
Marcia LeVatte et al.
Background: For thousands of years, disabilities due to nutrient deficiencies have plagued humanity. Rickets, scurvy, anemia, stunted growth, blindness, and mental handicaps due to nutrient deficiencies affected up to 1/1...
Dietary Intake and TCF7L2 rs7903146 T Allele Are Associated with Elevated Blood Glucose Levels in Healthy Individuals [0.03%]
饮食摄入和TCF7L2 rs7903146 T等位基因与健康个体的血糖水平升高有关
Isabela Cristina Ramos Podboi,Sophie Stephenson,Leta Pilic et al.
Isabela Cristina Ramos Podboi et al.
Introduction: Type 2 diabetes (T2D) is a leading cause of global mortality with diet and genetics being considered amongst the most significant risk factors. Recently, studies have identified a single polymorphism of the ...