Can a Lifestyle Genomics Intervention Motivate Patients to Engage in Greater Physical Activity than a Population-Based Intervention? Results from the NOW Randomized Controlled Trial [0.03%]
生活方式基因组干预能否比普通人群干预更激励患者进行更多的体育锻炼？来自NOW随机对照试验的结果
Justine R Horne,Jason Gilliland,Tara Leckie et al.
Justine R Horne et al.
Background: Lifestyle genomics (LGx) is a science that explores interactions between genetic variation, lifestyle components such as physical activity (PA), and subsequent health- and performance-related outcomes. The obj...
Randomized Controlled Trial
Lifestyle genomics. 2020;13(6):180-186. DOI:10.1159/000510216 2020
Fatty Acid Desaturase 3 (FADS3) Is a Specific ∆13-Desaturase of Ruminant trans-Vaccenic Acid [0.03%]
脂肪酸脱 saturase 3（FADS3）是 ruminant 反式 vaccenic 酸的特定∆13-脱 saturase
Vincent Rioux,Philippe Legrand
Vincent Rioux
In mammalian species, the Fatty Acid Desaturase (FADS) gene cluster includes FADS1 (∆5-desaturase), FADS2 (∆6-desaturase), and a third gene member, named FADS3. According to its high degree of nucleotide sequence homology with both FADS1a...
Alpinia zerumbet and Its Potential Use as an Herbal Medication for Atherosclerosis: Mechanistic Insights from Cell and Rodent Studies [0.03%]
零陵香及其作为动脉粥样硬化草药的潜在用途：来自细胞和啮齿类动物研究的机制见解
Ting Xiao,Jiaoyan Huang,Xiaowei Wang et al.
Ting Xiao et al.
Background/aims: Alpinia zerumbet (Pers.) Burtt. et Smith has been used as a flavor additive in food and a traditional medicine for centuries, especially in Guizhou Province, China, and it prolongs people's lives with mul...
Investigation of the Causal Association between Long-Chain n-6 Polyunsaturated Fatty Acid Synthesis and the Risk of Type 2 Diabetes: A Mendelian Randomization Analysis [0.03%]
长链n-6多不饱和脂肪酸合成与二型糖尿病风险的因果关联研究：一种孟德尔随机化分析
Michael A Zulyniak,Harriett Fuller,Mark M Iles
Michael A Zulyniak
Background: Globally, 1 in 11 adults has diabetes mellitus, and most of these cases are type 2 diabetes (T2D). The risk of T2D is influenced by many factors, including diet. The synthesis of long-chain n-6 polyunsaturated...
David M Mutch
David M Mutch
Lack of Association between LCT_rs140433552*CA>del Indel Polymorphism and Lactose Intolerance in a Southern Brazilian Population [0.03%]
LCT_rs140433552*CA>del插入/缺失多态性与南巴西人乳糖不耐受无相关性
Luana Caroline Oliveira,Andrey Lucas Dias Barros,Angelica Beate Winter Boldt et al.
Luana Caroline Oliveira et al.
Background/aims: Polymorphisms in the enhancer of the lactase gene (LCT) are strongly associated with lactase persistence, but not always predictive of the phenotype. We investigated a possible association between the reg...
The NASA Twins Study: The Effect of One Year in Space on Long-Chain Fatty Acid Desaturases and Elongases [0.03%]
NASA双生子研究：一年太空生活对长链脂肪酸去饱和酶和延长酶的影响
Michael A Schmidt,Cem Meydan,Caleb M Schmidt et al.
Michael A Schmidt et al.
Background: At present, there is no clear understanding of the effect of long-duration spaceflight on the major enzymes that govern the metabolism of omega-6 and omega-3 fatty acids. To address this gap in knowledge, we u...
What Will It Take to Build an Expert Group of Nutrigenomic Practitioners? [0.03%]
打造一支营养基因学实践专家队伍需要什么？
Yael Joffe,Heléne Herholdt
Yael Joffe
Background: The past two decades have seen exponential growth in the number of genetic testing companies, but only a small percentage of these tests are being sold through health care professionals (HCPs). As each new gen...
The Combined Effect of Polygenic Risk from FTO and ADRB2 Gene Variants, Odds of Obesity, and Post-Hipcref Diet Differences [0.03%]
FTO和ADRB2基因多态性的联合效应、肥胖几率与术后髋部参考饮食差异
Pui Yee Tan,Soma Roy Mitra
Pui Yee Tan
Background: Computing polygenic risk scores (PRS) to predict the degree of risk for obesity may contribute to weight management programs strategically. Ob...
Randomized Controlled Trial
Lifestyle genomics. 2020;13(2):84-98. DOI:10.1159/000505662 2020
The Association of Parental Genetic, Lifestyle, and Social Determinants of Health with Offspring Overweight [0.03%]
父母遗传、生活方式和社会健康决定因素与子女超重的关系
Catherine A M Graham,Charles R Pedlar,Gary Hearne et al.
Catherine A M Graham et al.
Introduction: In the UK, the number of comorbidities seen in children has increased along with the worsening obesity rate. These comorbidities worsen into adulthood. Genome-wide association studies have highlighted single...