Analysis of the structure and function of the tomato Solanum lycopersicum L. MADS-box gene SlMADS5 [0.03%]
番茄Solanum lycopersicum L. 的MADS盒基因SlMADS5的结构和功能分析
A V Nezhdanova,M A Slugina,E A Dyachenko et al.
A V Nezhdanova et al.
At all stages of f lowering, a decisive role is played by the family of MADS-domain transcription factors, the combinatorial action of which is described by the ABCDE-model of f lower development. The current volume of data suggests a high ...
Вариабельность последовательности D-петли митохондриальной ДНК у лошадей забайкальской породы [0.03%]
外贝加尔马种线粒体DNA D-loop序列变异研究
L A Khrabrova,N V Blohina,B Z Bazaron et al.
L A Khrabrova et al.
The Zabaikalskaya horse is an indigenous breed of horses from Siberia with diverse use. It is characterized by endurance and good adaptability to year-round herd maintenance in the harsh conditions of the Baikal steppes. To determine the ge...
Parent-of-origin effects on nuclear chromatin organization and behavior in a Drosophila model for Williams-Beuren Syndrome [0.03%]
父母来源效应在果蝇Williams-Beuren综合征模型中对核染色质组织和行为的影响
A V Medvedeva,E V Tokmatcheva,A N Kaminskaya et al.
A V Medvedeva et al.
Prognosis of neuropsychiatric disorders in progeny requires consideration of individual (1) parent-of-origin effects (POEs) relying on (2) the nerve cell nuclear 3D chromatin architecture and (3) impact of parent-specific miRNAs. Additional...
The transcription factor dfoxo controls the expression of insulin pathway genes and lipids content under heat stress in Drosophila melanogaster [0.03%]
转录因子dfoxo控制果蝇中在热胁迫下胰岛素通路基因和脂类含量的表达
M A Eremina,P N Menshanov,O D Shishkina et al.
M A Eremina et al.
The insulin/insulin-like growth factor signaling (IIS) pathway is one of the key elements in an organism's response to unfavourable conditions. The deep homology of this pathway and its evolutionary conservative role in controlling the carb...
Application of alternative de novo motif recognition models for analysis of structural heterogeneity of transcription factor binding sites: a case study of FOXA2 binding sites [0.03%]
替代从头基序识别模型在转录因子结合位点结构异质性分析中的应用：FOXA2 结合位点的研究案例
A V Tsukanov,V G Levitsky,T I Merkulova
A V Tsukanov
The most popular model for the search of ChIP-seq data for transcription factor binding sites (TFBS) is the positional weight matrix (PWM). However, this model does not take into account dependencies between nucleotide occurrences in differ...
Disease-associated genetic variants in the regulatory regions of human genes: mechanisms of action on transcription and genomic resources for dissecting these mechanisms [0.03%]
人类基因调控区域中与疾病相关的遗传变异：对转录作用机制的解析及其基因组资源
E V Ignatieva,E A Matrosova
E V Ignatieva
Whole genome and whole exome sequencing technologies play a very important role in the studies of the genetic aspects of the pathogenesis of various diseases. The ample use of genome-wide and exome-wide association study methodology (GWAS a...
mRNA technology as one of the promising platforms for the SARS-CoV-2 vaccine development [0.03%]
基于mRNA技术的新型冠状病毒疫苗研发平台
A A Ilyichev,L A Orlova,S V Sharabrin et al.
A A Ilyichev et al.
After the genome sequence of SARS-CoV-2 (Severe acute respiratory syndrome-related coronavirus 2) was published and the number of infected people began to increase rapidly, many global companies began to develop a vaccine. Almost all known ...
[Ecological and genetic assessment of the consequences of radiation influence on contaminated areas] [0.03%]
[辐射污染区生态和遗传影响的评估]
A B Bigaliev,K Z Shalabaeva,B E Shimshikov et al.
A B Bigaliev et al.
The objects of study are the territory of the districts of the West Kazakhstan region of the Republic of Kazakhstan adjacent to the Kapustin Yar test site: Bokeyordinsky, Zhangalinsky, Zhanibeksky, Kaztalovsky, Akzhayiksky and Syrymsky. The...
[Candidate SNP-markers altering TBP binding affinity for promoters of the Y-linked genes CDY2A, SHOX, and ZFY are lowering many indexes of reproductive potential in men] [0.03%]
候选SNP标记物改变了Y染色体基因CDY2A、SHOX和ZFY启动子的TBP结合亲和力，从而降低了男性的多种生殖潜能指标
M P Ponomarenko,E B Sharypova,I A Drachkova et al.
M P Ponomarenko et al.
Reproductive potential is the most important conditional indicator reflecting the ability of individuals in a population to reproduce, survive and develop under optimal environmental conditions. As for humans, the concept of reproductive po...
The cell cycle regulatory gene polymorphisms TP53 (rs1042522) and MDM2 (rs2279744) in lung cancer: a meta-analysis [0.03%]
肺癌中调控细胞周期的基因多态性TP53（rs1042522）和MDM2（rs2279744）：一项系统评价和meta-分析
O Bulgakova,A Kussainova,R Bersimbaev
O Bulgakova
Lung cancer is one of the most common types of cancer in the world. Although the mechanism of lung cancer is still unknown, a large number of studies have found a link between gene polymorphisms and the risk of lung cancer. The tumor suppre...